| Tag | Content |
|---|---|
| Uniprot ID | A0A452EKB2 |
| Entrez ID | 102187775 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_013967594.2 |
| Ensembl protein ID | ENSCHIP00000012374 |
| Ensembl nucleotide ID | ENSCHIG00000014147 |
| Gene name | 3-hydroxyanthranilate 3,4-dioxygenase |
| Gene symbol | HAAO |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| Sequence | MESPVRVKAW VEENRGSFLP PVCNKLLHQK QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 60 DMLLRVLERG KHRDVVIRQG EIFLLPAGVP HSPQRFANTV GLVIERRRLK TELDGLRYYV 120 GDTTDVLFEK WFYCEDLGTQ LAPIIQEFFS SEQYRTGKPN PDQLLKEPPF PLSTRSVMEP 180 MCLEAWLDGH RKELQAGTPL SLFGDTYESQ VMIHGQGSSK GLRRDVDVWL WQLEGSSVVT 240 MEGQRLSLTP DDSLLVPAGT LYGWERGQGS VALSVTQDPA CKKSLG 286 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HAAO | 510602 | Q0VCA8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 102187775 | A0A452EKB2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HAAO | 23498 | P46952 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Haao | 107766 | Q78JT3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HAAO | 737730 | A0A2I3TGC8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | HAAO | G1TAA6 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Haao | A0A0G2JSV5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | haao | 492518 | F1QYC7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005829 | cytosol |
| GO:0000334 | 3-hydroxyanthranilate 3,4-dioxygenase activity |
| GO:0008198 | ferrous iron binding |
| GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan |
| GO:0043420 | anthranilate metabolic process |
| GO:0070050 | neuron cellular homeostasis |
| GO:0019805 | quinolinate biosynthetic process |
| GO:0046686 | response to cadmium ion |
| GO:0010043 | response to zinc ion |
| GO:0006569 | tryptophan catabolic process |
| Pfam ID | Pfam Term |
|---|---|
| PF06052 | 3-HAO |