Gene: CDC42

Basic information

Tag Content
Uniprot ID A0A2I3TL10; A0A2J8K464;
Entrez ID 456609
Genbank protein ID
Genbank nucleotide ID XM_009450093.2; XM_009450094.2;
Ensembl protein ID ENSPTRP00000089608
Ensembl nucleotide ID ENSPTRG00000051031
Gene name Cell division cycle 42
Gene symbol CDC42
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG 60
QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR 120
DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQRGLKNVFD EAILAALEPP 180
ETQPKRKCCI F 191

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDC42403934P60952Canis lupus familiarisPredictionMore>>
1:1 orthologCDC42102188638A0A452EIX9Capra hircusPredictionMore>>
1:1 orthologCDC42998P60953Homo sapiensPredictionMore>>
1:1 orthologCdc4212540P60766CPO,CLPMus musculusPublicationMore>>
1:1 orthologCDC42456609A0A2I3TL10Pan troglodytesPredictionMore>>
1:1 orthologCDC42780428F2Z5W2Sus scrofaPredictionMore>>
1:1 orthologCdc4264465A0A0G2JSM8Rattus norvegicusPredictionMore>>
1:1 orthologcdc42336839Q6PFU4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005938 cell cortex
GO:0042995 cell projection
GO:0005737 cytoplasm
GO:0031410 cytoplasmic vesicle
GO:0005856 cytoskeleton
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043005 neuron projection
GO:0005886 plasma membrane
GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0019901 protein kinase binding
GO:0030036 actin cytoskeleton organization
GO:0007015 actin filament organization
GO:0032488 Cdc42 protein signal transduction
GO:0016477 cell migration
GO:0030031 cell projection assembly
GO:0030865 cortical cytoskeleton organization
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0099563 modification of synaptic structure
GO:0032956 regulation of actin cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0007266 Rho protein signal transduction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR037874 Cdc42
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho

PROSITE

PROSITE ID PROSITE Term
PS51420 RHO

Pfam

Pfam ID Pfam Term
PF00071 Ras