Gene: cdc42

Basic information

Tag Content
Uniprot ID Q6PFU4
Entrez ID 336839
Genbank protein ID AAH57415.1
Genbank nucleotide ID NM_200632.2
Ensembl protein ID ENSDARP00000129339; ENSDARP00000149720;
Ensembl nucleotide ID ENSDARG00000044573
Gene name Cell division control protein 42 homolog
Gene symbol cdc42
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
Sequence
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG 60
QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR 120
DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP 180
EPKKKRKCVL L 191

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDC42403934P60952Canis lupus familiarisPredictionMore>>
1:1 orthologCDC42102188638A0A452EIX9Capra hircusPredictionMore>>
1:1 orthologCDC42998P60953Homo sapiensPredictionMore>>
1:1 orthologCdc4212540P60766CPO,CLPMus musculusPublicationMore>>
1:1 orthologCDC42456609A0A2I3TL10Pan troglodytesPredictionMore>>
1:1 orthologCDC42780428F2Z5W2Sus scrofaPredictionMore>>
1:1 orthologCdc4264465A0A0G2JSM8Rattus norvegicusPredictionMore>>
1:1 orthologcdc42336839Q6PFU4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030496 midbody
GO:0005886 plasma membrane
GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0062139 camera-type eye photoreceptor cell development
GO:0032488 Cdc42 protein signal transduction
GO:0051301 cell division
GO:0016477 cell migration
GO:0042074 cell migration involved in gastrulation
GO:0030031 cell projection assembly
GO:0060271 cilium assembly
GO:0006897 endocytosis
GO:0046847 filopodium assembly
GO:0007229 integrin-mediated signaling pathway
GO:0001822 kidney development
GO:0032402 melanosome transport
GO:0038189 neuropilin signaling pathway
GO:0042461 photoreceptor cell development
GO:0045494 photoreceptor cell maintenance
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0051491 positive regulation of filopodium assembly
GO:0060041 retina development in camera-type eye
GO:0002040 sprouting angiogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0131 Cell cycle
KW-0132 Cell division
KW-1003 Cell membrane
KW-0342 GTP-binding
KW-0449 Lipoprotein
KW-0472 Membrane
KW-0547 Nucleotide-binding
KW-0636 Prenylation
KW-1267 Proteomics identification
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR037874 Cdc42
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho

PROSITE

PROSITE ID PROSITE Term
PS51420 RHO

Pfam

Pfam ID Pfam Term
PF00071 Ras