| Tag | Content |
|---|---|
| Uniprot ID | P60952; P21181; P25763; |
| Entrez ID | 403934 |
| Genbank protein ID | CAA90215.1 |
| Genbank nucleotide ID | NM_001003254.2 |
| Ensembl protein ID | ENSCAFP00040003996; ENSCAFP00000021683; ENSCAFP00000021684; ENSCAFP00030003518; ENSCAFP00040002961; |
| Ensembl nucleotide ID | ENSCAFG00040001840; ENSCAFG00040002443; ENSCAFG00030002163; ENSCAFG00000014707; |
| Gene name | Cell division control protein 42 homolog |
| Gene symbol | CDC42 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). |
| Sequence | MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG 60 QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR 120 DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP 180 EPKKSRRCVL L 191 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDC42 | 403934 | P60952 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CDC42 | 102188638 | A0A452EIX9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CDC42 | 998 | P60953 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cdc42 | 12540 | P60766 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CDC42 | 456609 | A0A2I3TL10 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CDC42 | 780428 | F2Z5W2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Cdc42 | 64465 | A0A0G2JSM8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | cdc42 | 336839 | Q6PFU4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005938 | cell cortex |
| GO:0042995 | cell projection |
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005856 | cytoskeleton |
| GO:0043197 | dendritic spine |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0031258 | lamellipodium membrane |
| GO:0016020 | membrane |
| GO:0005815 | microtubule organizing center |
| GO:0030496 | midbody |
| GO:0072686 | mitotic spindle |
| GO:0043005 | neuron projection |
| GO:0005886 | plasma membrane |
| GO:0051233 | spindle midzone |
| GO:0005525 | GTP binding |
| GO:0003924 | GTPase activity |
| GO:0019901 | protein kinase binding |
| GO:0030036 | actin cytoskeleton organization |
| GO:0007015 | actin filament organization |
| GO:0032488 | Cdc42 protein signal transduction |
| GO:0034329 | cell junction assembly |
| GO:0016477 | cell migration |
| GO:0030031 | cell projection assembly |
| GO:0030865 | cortical cytoskeleton organization |
| GO:0060997 | dendritic spine morphogenesis |
| GO:0006897 | endocytosis |
| GO:0045198 | establishment of epithelial cell apical/basal polarity |
| GO:0007163 | establishment or maintenance of cell polarity |
| GO:0099563 | modification of synaptic structure |
| GO:0006911 | phagocytosis, engulfment |
| GO:0032467 | positive regulation of cytokinesis |
| GO:0051491 | positive regulation of filopodium assembly |
| GO:0048549 | positive regulation of pinocytosis |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| GO:0032956 | regulation of actin cytoskeleton organization |
| GO:0051988 | regulation of attachment of spindle microtubules to kinetochore |
| GO:0008360 | regulation of cell shape |
| GO:0051489 | regulation of filopodium assembly |
| GO:0007266 | Rho protein signal transduction |
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0221 | Differentiation |
| KW-0342 | GTP-binding |
| KW-0378 | Hydrolase |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0488 | Methylation |
| KW-0524 | Neurogenesis |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0636 | Prenylation |
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51420 | RHO |
| Pfam ID | Pfam Term |
|---|---|
| PF00071 | Ras |