| Tag | Content |
|---|---|
| Uniprot ID | P60766; A2A9U6; P21181; P25763; Q3THZ7; Q3TJK6; Q545V0; Q6P201; Q8BQ51; |
| Entrez ID | 12540 |
| Genbank protein ID | BAC34669.1; AAA37410.1; BAE39663.1; BAE25778.1; BAE38678.1; BAE40222.1; BAC35825.1; AAH64792.1; BAE32891.1; BAE32098.1; BAE40049.1; BAE41001.1; BAE30644.1; BAE40902.1; BAE40595.1; AAC00028.1; BAE40647.1; BAE35111.1; BAE41379.1; BAB22563.1; BAE40062.1; BAE39325.1; AAB40051.1; BAE39489.1; BAE40000.1; BAE30100.1; |
| Genbank nucleotide ID | NM_009861.3; NM_001243769.1; |
| Ensembl protein ID | ENSMUSP00000030417; ENSMUSP00000054634; |
| Ensembl nucleotide ID | ENSMUSG00000006699 |
| Gene name | Cell division control protein 42 homolog |
| Gene symbol | Cdc42 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 24056078; 22387309; |
| Functional description | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:24352656). In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons (PubMed:25851601). Facilitates filopodia formation upon DOCK11-activation (PubMed:22494997). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). |
| Sequence | MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG 60 QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR 120 DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP 180 EPKKSRRCVL L 191 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDC42 | 403934 | P60952 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CDC42 | 102188638 | A0A452EIX9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CDC42 | 998 | P60953 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cdc42 | 12540 | P60766 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CDC42 | 456609 | A0A2I3TL10 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CDC42 | 780428 | F2Z5W2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Cdc42 | 64465 | A0A0G2JSM8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | cdc42 | 336839 | Q6PFU4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003924 | GTPase activity | TAS |
| GO:0003924 | GTPase activity | IDA |
| GO:0003924 | GTPase activity | ISA |
| GO:0003924 | GTPase activity | IGI |
| GO:0003924 | GTPase activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | ISO |
| GO:0005525 | GTP binding | IBA |
| GO:0019901 | protein kinase binding | IPI |
| GO:0019901 | protein kinase binding | IBA |
| GO:0030742 | GTP-dependent protein binding | IPI |
| GO:0031435 | mitogen-activated protein kinase kinase kinase binding | ISO |
| GO:0031996 | thioesterase binding | IEA |
| GO:0032427 | GBD domain binding | IEA |
| GO:0034191 | apolipoprotein A-I receptor binding | IEA |
| GO:0042802 | identical protein binding | IEA |
| GO:0061630 | ubiquitin protein ligase activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002040 | sprouting angiogenesis | ISO |
| GO:0003161 | cardiac conduction system development | IGI |
| GO:0006897 | endocytosis | IBA |
| GO:0006897 | endocytosis | IMP |
| GO:0006911 | phagocytosis, engulfment | ISS |
| GO:0007015 | actin filament organization | ISS |
| GO:0007015 | actin filament organization | ISO |
| GO:0007015 | actin filament organization | IBA |
| GO:0007030 | Golgi organization | ISO |
| GO:0007088 | regulation of mitotic nuclear division | IMP |
| GO:0007097 | nuclear migration | IMP |
| GO:0007163 | establishment or maintenance of cell polarity | TAS |
| GO:0007163 | establishment or maintenance of cell polarity | IBA |
| GO:0007229 | integrin-mediated signaling pathway | IEA |
| GO:0007266 | Rho protein signal transduction | TAS |
| GO:0007266 | Rho protein signal transduction | IBA |
| GO:0008360 | regulation of cell shape | IBA |
| GO:0010592 | positive regulation of lamellipodium assembly | IEA |
| GO:0016197 | endosomal transport | TAS |
| GO:0016477 | cell migration | IBA |
| GO:0016567 | protein ubiquitination | IEA |
| GO:0030031 | cell projection assembly | IBA |
| GO:0030036 | actin cytoskeleton organization | IBA |
| GO:0030307 | positive regulation of cell growth | IEA |
| GO:0030865 | cortical cytoskeleton organization | IBA |
| GO:0031274 | positive regulation of pseudopodium assembly | IEA |
| GO:0031333 | negative regulation of protein-containing complex assembly | IEA |
| GO:0032467 | positive regulation of cytokinesis | ISS |
| GO:0032488 | Cdc42 protein signal transduction | ISO |
| GO:0032488 | Cdc42 protein signal transduction | IBA |
| GO:0032956 | regulation of actin cytoskeleton organization | IBA |
| GO:0034329 | cell junction assembly | ISS |
| GO:0034332 | adherens junction organization | IMP |
| GO:0034613 | cellular protein localization | IMP |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | IMP |
| GO:0036336 | dendritic cell migration | IGI |
| GO:0038189 | neuropilin signaling pathway | IEA |
| GO:0039694 | viral RNA genome replication | IEA |
| GO:0043085 | positive regulation of catalytic activity | ISO |
| GO:0043393 | regulation of protein binding | IDA |
| GO:0043410 | positive regulation of MAPK cascade | IDA |
| GO:0043525 | positive regulation of neuron apoptotic process | ISO |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | IMP |
| GO:0045198 | establishment of epithelial cell apical/basal polarity | ISS |
| GO:0045740 | positive regulation of DNA replication | ISO |
| GO:0046330 | positive regulation of JNK cascade | ISO |
| GO:0046847 | filopodium assembly | IDA |
| GO:0048549 | positive regulation of pinocytosis | IMP |
| GO:0048664 | neuron fate determination | IMP |
| GO:0051489 | regulation of filopodium assembly | ISS |
| GO:0051491 | positive regulation of filopodium assembly | IMP |
| GO:0051496 | positive regulation of stress fiber assembly | IEA |
| GO:0051647 | nucleus localization | IMP |
| GO:0051683 | establishment of Golgi localization | ISO |
| GO:0051835 | positive regulation of synapse structural plasticity | ISO |
| GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | ISS |
| GO:0060047 | heart contraction | IGI |
| GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis | IMP |
| GO:0060661 | submandibular salivary gland formation | IEA |
| GO:0060997 | dendritic spine morphogenesis | IMP |
| GO:0071346 | cellular response to interferon-gamma | IDA |
| GO:0072384 | organelle transport along microtubule | ISO |
| GO:0090135 | actin filament branching | ISO |
| GO:0090316 | positive regulation of intracellular protein transport | ISO |
| GO:0098609 | cell-cell adhesion | TAS |
| GO:0099159 | regulation of modification of postsynaptic structure | ISO |
| GO:0099563 | modification of synaptic structure | ISO |
| GO:0099563 | modification of synaptic structure | IBA |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | ISS |
| GO:2000251 | positive regulation of actin cytoskeleton reorganization | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | ISO |
| GO:0000322 | storage vacuole | IDA |
| GO:0005623 | cell | IEA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005737 | cytoplasm | IBA |
| GO:0005813 | centrosome | IEA |
| GO:0005829 | cytosol | IDA |
| GO:0005856 | cytoskeleton | IBA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | IBA |
| GO:0005886 | plasma membrane | TAS |
| GO:0005911 | cell-cell junction | IDA |
| GO:0005938 | cell cortex | IBA |
| GO:0016020 | membrane | ISS |
| GO:0017119 | Golgi transport complex | IEA |
| GO:0030141 | secretory granule | ISO |
| GO:0030175 | filopodium | IEA |
| GO:0030496 | midbody | ISS |
| GO:0031256 | leading edge membrane | IDA |
| GO:0031258 | lamellipodium membrane | IEA |
| GO:0031410 | cytoplasmic vesicle | IBA |
| GO:0036464 | cytoplasmic ribonucleoprotein granule | IEA |
| GO:0042995 | cell projection | IDA |
| GO:0042995 | cell projection | IBA |
| GO:0043005 | neuron projection | IBA |
| GO:0043025 | neuronal cell body | IEA |
| GO:0043197 | dendritic spine | IBA |
| GO:0043209 | myelin sheath | HDA |
| GO:0043231 | intracellular membrane-bounded organelle | IBA |
| GO:0045177 | apical part of cell | IDA |
| GO:0045335 | phagocytic vesicle | IDA |
| GO:0051233 | spindle midzone | ISS |
| GO:0071944 | cell periphery | IDA |
| GO:0072686 | mitotic spindle | ISS |
| GO:0098685 | Schaffer collateral - CA1 synapse | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-114604 | GPVI-mediated activation cascade | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-177929 | Signaling by EGFR | IEA |
| R-MMU-182971 | EGFR downregulation | IEA |
| R-MMU-194138 | Signaling by VEGF | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-194840 | Rho GTPase cycle | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | IEA |
| R-MMU-2029482 | Regulation of actin dynamics for phagocytic cup formation | IEA |
| R-MMU-2682334 | EPH-Ephrin signaling | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-373752 | Netrin-1 signaling | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-388841 | Costimulation by the CD28 family | IEA |
| R-MMU-389356 | CD28 co-stimulation | IEA |
| R-MMU-389359 | CD28 dependent Vav1 pathway | IEA |
| R-MMU-3928662 | EPHB-mediated forward signaling | IEA |
| R-MMU-397795 | G-protein beta:gamma signalling | IEA |
| R-MMU-418885 | DCC mediated attractive signaling | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-4420097 | VEGFA-VEGFR2 Pathway | IEA |
| R-MMU-525793 | Myogenesis | IEA |
| R-MMU-5625970 | RHO GTPases activate KTN1 | IEA |
| R-MMU-5626467 | RHO GTPases activate IQGAPs | IEA |
| R-MMU-5627123 | RHO GTPases activate PAKs | IEA |
| R-MMU-5663213 | RHO GTPases Activate WASPs and WAVEs | IEA |
| R-MMU-5663220 | RHO GTPases Activate Formins | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5687128 | MAPK6/MAPK4 signaling | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-8964616 | G beta:gamma signalling through CDC42 | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-983231 | Factors involved in megakaryocyte development and platelet production | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0221 | Differentiation |
| KW-0903 | Direct protein sequencing |
| KW-0342 | GTP-binding |
| KW-0378 | Hydrolase |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0488 | Methylation |
| KW-0524 | Neurogenesis |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0636 | Prenylation |
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51420 | RHO |
| Pfam ID | Pfam Term |
|---|---|
| PF00071 | Ras |