| Tag | Content |
|---|---|
| Uniprot ID | A0A2J8P0L4; H2PYC2; |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000000612 |
| Ensembl nucleotide ID | ENSPTRG00000018228 |
| Gene name | Runt-related transcription factor |
| Gene symbol | RUNX2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. |
| Sequence | MASNSLFSTV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS DVSPVVAAQQ QQQQQQQQQQ 60 QQQQQQQQQQ QQQEAAAAAA AAAAAAAAAA AVPRLRPPHD NRTMVEIIAD HPAELVRTDS 120 PNFLCSVLPS HWRCNKTLPV AFKVVALGEV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ 180 VARFNDLRFV GRSGRGKSFT LTITVFTNPP QVATYHRAIK VTVDGPREPR RHRQKLDDSK 240 PSLFSDRLSD LGRIPHPSMR VGVPPQNPRP SLNSAPSPFN PQGQSQITDP RQAQSSPPWS 300 YDQSYPSYLS QMTSPSIHST TPLSSTRGTG LPAITDVPRR ISDDDTATSD FCLWPSTLSK 360 KSQAGASELG PFSDPRQFPS ISSLTESRFS NPRMHYPATF TYTPPVTSGM SLGMSATTHY 420 HTYLPPPYPG SSQSQSGPFQ TSSTPYLYYG TSSGSYQFPM VPGGDRSPSR MLPPCTTTSN 480 GSTLLNPNLP NQNDGVDADG SHSSSPTVLN SSGRMDESVW RPY 523 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RUNX2 | 102183278 | A0A452ETJ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RUNX2 | 860 | Q13950 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Runx2 | 12393 | Q08775 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RUNX2 | A0A2J8P0L4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Runx2 | 367218 | F1M9C5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | runx2a | F1R272 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51062 | RUNT |