| Tag | Content |
|---|---|
| Uniprot ID | F1M9C5 |
| Entrez ID | 367218 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001278483.1 |
| Ensembl protein ID | ENSRNOP00000057733 |
| Ensembl nucleotide ID | ENSRNOG00000020193 |
| Gene name | Runt-related transcription factor |
| Gene symbol | Runx2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. |
| Sequence | MASNSLFSAV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS DVSPVVAAQQ QQQQQQQQQQ 60 QQQQQQQQQQ QQQQQQQQQE AAAAAAAAAA AAAAAAAVPR LRPPHDNRTM VEIIADHPAE 120 LVRTDSPNFL CSVLPSHWRC NKTLPVAFKV VALGEVPDGT VVTVMAGNDE NYSAELRNAS 180 AVMKNQVARF NDLRFVGRSG RGKSFTLTIT VFTNPPQVAT YHRAIKVTVD GPREPRRHRQ 240 KLDDSKPSLF SDRLSDLGRI PHPSMRVGVP PQNPRPSLNS APSPFNPQGQ SQITDPRQTQ 300 SSPPWSYDQS YPSYLSQMTS PSIHSTTPLS STRGTGLPAI TDVPRRISDD DTATSDFCLW 360 PSSLSKKSQA GASELGPFSD PRQFPGISSL TESRFSNPRM HYPATFTYTP PVTSGMSLGM 420 SATTHYHTYL PPPYPGSSQS QSGPFQTSST PYLYYGTSSA SYQFPMVPGG DRSPSRMVPP 480 CTTTSNGSTL LNPNLPNQND GVDADGSHSS SPTVLNSSGR MDESVWRPY 529 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RUNX2 | 102183278 | A0A452ETJ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RUNX2 | 860 | Q13950 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Runx2 | 12393 | Q08775 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RUNX2 | A0A2J8P0L4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Runx2 | 367218 | F1M9C5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | runx2a | F1R272 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0005667 | transcription factor complex |
| GO:0005524 | ATP binding |
| GO:0043425 | bHLH transcription factor binding |
| GO:0003682 | chromatin binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0019904 | protein domain specific binding |
| GO:0070491 | repressing transcription factor binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0030509 | BMP signaling pathway |
| GO:0048469 | cell maturation |
| GO:0002063 | chondrocyte development |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0001958 | endochondral ossification |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0002076 | osteoblast development |
| GO:0002051 | osteoblast fate commitment |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032332 | positive regulation of chondrocyte differentiation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth |
| GO:0048863 | stem cell differentiation |
| GO:0030217 | T cell differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51062 | RUNT |