| Tag | Content |
|---|---|
| Uniprot ID | A0A452ETJ7 |
| Entrez ID | 102183278 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018038794.1 |
| Ensembl protein ID | ENSCHIP00000015440 |
| Ensembl nucleotide ID | ENSCHIG00000016080 |
| Gene name | Runt-related transcription factor |
| Gene symbol | RUNX2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. |
| Sequence | MASNSLFSTV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS DVSPVVAAQQ QQQQQQQQQQ 60 QQQQQQQQQQ EAAAAAAAAA AAAAAAAVPR LRPPHDNRTM VEIIADHPAE LVRTDSPNFL 120 CSVLPSHWRC NKTLPVAFKV VALGEVPDGT VVTVMAGNDE NYSAELRNAS AVMKNQVARF 180 NDLRFVGRSG RGKSFTLTIT VFTNPPQVAT YHRAIKVTVD GPREPRRHRQ KLDDSKPSLF 240 SDRLSDLGRI PHPSMRVGVP PQNPRPSLNS APSPFNPQGQ SQITDPRQAQ SSPPWSYDQS 300 YPSYLSQMTP PSIHSTTPLS STRGTGLPAI TDVPRRISDD DTATSDFCLW PSTLSKKSQA 360 GASELGPFSD PRQFPSISSL TESRFSNPRM HYPATFTYTP PVTSGMSLGM SATTHYHTYL 420 PPPYPGSSQS QSGPFQTSST PYLYYGTSSG SYQFPMVPGG DRSPSRMLPP CTTTSNGSTL 480 LNPNLPTQND GVDADGSHSS SPTVLNSSGR MDESVWRPY 519 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RUNX2 | 102183278 | A0A452ETJ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RUNX2 | 860 | Q13950 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Runx2 | 12393 | Q08775 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RUNX2 | A0A2J8P0L4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Runx2 | 367218 | F1M9C5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | runx2a | F1R272 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51062 | RUNT |