| Tag | Content |
|---|---|
| Uniprot ID | F1R272 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000116368 |
| Ensembl nucleotide ID | ENSDARG00000040261 |
| Gene name | Runt-related transcription factor |
| Gene symbol | runx2a |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRIPVDPSTS RRFSPPSSSL QPVAGKMSDA QPEPNAVVPR LRPHDNRTMV EIIADHPAEL 60 VRTDSPNFLC SVLPSHWRCN KTLPVAFKVV ALGDVPDGTV VTVMAGNDEN YSAELRNASA 120 VMKNQVARFN DLRFVGRSGR GKSFTLTITV FTNPPQVATY HRAIKVTVDG PREPRRHRQK 180 LEDPPKPPLF SERLSELERL RQTTMRVAVQ TQSPRPSLNA TPNSFNPQGQ TQISDPRQVQ 240 SSPPWSYEQP YPPYLSQMTS PSIHSTTPLS STRATGLPTI SDVPRRLSGT SELSPFSADP 300 RQFERQFPSL SSLTDSRFPS PRMHYPATFT YTPTPVTSGM SLGMSTTTHY HTYLPPPYPG 360 STQNQSGPFQ TSSTPYLYYG ASSGSYQFSM VPGGDRSPSR MLPPCTSAST GSTLINPNLP 420 NQTDGGEADG SHSSSPTVLN SSGRMDESVW RPY 453 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RUNX2 | 102183278 | A0A452ETJ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RUNX2 | 860 | Q13950 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Runx2 | 12393 | Q08775 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RUNX2 | A0A2J8P0L4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Runx2 | 367218 | F1M9C5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | runx2a | F1R272 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0002062 | chondrocyte differentiation |
| GO:0030097 | hemopoiesis |
| GO:0030182 | neuron differentiation |
| GO:0001503 | ossification |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0045595 | regulation of cell differentiation |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51062 | RUNT |