Gene: ILK

Basic information

Tag Content
Uniprot ID A0A3Q2H733
Entrez ID 100070066
Genbank protein ID
Genbank nucleotide ID XM_001504599.4
Ensembl protein ID ENSECAP00000029258
Ensembl nucleotide ID ENSECAG00000007599
Gene name Integrin linked kinase
Gene symbol ILK
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60
NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120
ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180
TLNKHSGIDF KQLNFLAKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 240
RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300
MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360
LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420
VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologILK476836E2R5H4Canis lupus familiarisPredictionMore>>
1:1 orthologILK102177259A0A452F0A3Capra hircusPredictionMore>>
1:1 orthologILK100070066A0A3Q2H733Equus caballusPredictionMore>>
1:1 orthologILKA0A0A0MTH3Homo sapiensPredictionMore>>
1:1 orthologIlk16202O55222CPOMus musculusPublicationMore>>
1:1 orthologILK748941A0A2I3T709Pan troglodytesPredictionMore>>
1:1 orthologIlk170922Q99J82Rattus norvegicusPredictionMore>>
1:1 orthologilk393543Q6PHD6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0030027 lamellipodium
GO:0005654 nucleoplasm
GO:0005524 ATP binding
GO:0019901 protein kinase binding
GO:0004674 protein serine/threonine kinase activity
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0030030 cell projection organization
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0010761 fibroblast migration
GO:0007229 integrin-mediated signaling pathway
GO:0022011 myelination in peripheral nervous system
GO:2000178 negative regulation of neural precursor cell proliferation
GO:0021675 nerve development
GO:0003151 outflow tract morphogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0030513 positive regulation of BMP signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:0045669 positive regulation of osteoblast differentiation
GO:0001934 positive regulation of protein phosphorylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0043491 protein kinase B signaling
GO:0034446 substrate adhesion-dependent cell spreading
GO:0033209 tumor necrosis factor-mediated signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0040 ANK repeat
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR035692 PK_ILK
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom

PROSITE

PROSITE ID PROSITE Term
PS50297 ANK_REP_REGION
PS50088 ANK_REPEAT
PS50011 PROTEIN_KINASE_DOM

Pfam

Pfam ID Pfam Term
PF07714 Pkinase_Tyr