Gene: Ilk

Basic information

Tag Content
Uniprot ID O55222; Q78KK2;
Entrez ID 16202
Genbank protein ID AAB94646.1; AAH03737.1;
Genbank nucleotide ID NM_001161724.1; NM_010562.2;
Ensembl protein ID ENSMUSP00000130341; ENSMUSP00000033182;
Ensembl nucleotide ID ENSMUSG00000030890
Gene name Integrin-linked protein kinase
Gene symbol Ilk
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 12671688
Functional description Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Sequence
MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60
NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120
ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180
TLNKHSGIDF KQLNFLAKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 240
RLRIFSHPNV LPVLGACQAP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300
MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360
LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420
VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologILK476836E2R5H4Canis lupus familiarisPredictionMore>>
1:1 orthologILK102177259A0A452F0A3Capra hircusPredictionMore>>
1:1 orthologILK100070066A0A3Q2H733Equus caballusPredictionMore>>
1:1 orthologILKA0A0A0MTH3Homo sapiensPredictionMore>>
1:1 orthologIlk16202O55222CPOMus musculusPublicationMore>>
1:1 orthologILK748941A0A2I3T709Pan troglodytesPredictionMore>>
1:1 orthologIlk170922Q99J82Rattus norvegicusPredictionMore>>
1:1 orthologilk393543Q6PHD6Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004672 protein kinase activityISO
GO:0004674 protein serine/threonine kinase activityISO
GO:0004674 protein serine/threonine kinase activityIBA
GO:0005178 integrin bindingISO
GO:0005515 protein bindingIPI
GO:0005524 ATP bindingIEA
GO:0017124 SH3 domain bindingISO
GO:0019901 protein kinase bindingISO
GO:0019904 protein domain specific bindingISO
GO:0044877 protein-containing complex bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0001558 regulation of cell growthISO
GO:0001658 branching involved in ureteric bud morphogenesisIDA
GO:0001934 positive regulation of protein phosphorylationISO
GO:0001954 positive regulation of cell-matrix adhesionISO
GO:0003151 outflow tract morphogenesisIMP
GO:0006468 protein phosphorylationISO
GO:0006469 negative regulation of protein kinase activityISO
GO:0007050 cell cycle arrestISO
GO:0007160 cell-matrix adhesionIBA
GO:0007229 integrin-mediated signaling pathwayISO
GO:0007229 integrin-mediated signaling pathwayIBA
GO:0007569 cell agingISO
GO:0008284 positive regulation of cell population proliferationISO
GO:0008284 positive regulation of cell population proliferationIMP
GO:0009967 positive regulation of signal transductionISO
GO:0010667 negative regulation of cardiac muscle cell apoptotic processISO
GO:0010761 fibroblast migrationIMP
GO:0014044 Schwann cell developmentIMP
GO:0014912 negative regulation of smooth muscle cell migrationISO
GO:0018105 peptidyl-serine phosphorylationISO
GO:0018105 peptidyl-serine phosphorylationIMP
GO:0021675 nerve developmentIMP
GO:0022011 myelination in peripheral nervous systemIMP
GO:0030030 cell projection organizationIMP
GO:0030335 positive regulation of cell migrationISO
GO:0030513 positive regulation of BMP signaling pathwayIMP
GO:0032288 myelin assemblyISO
GO:0032956 regulation of actin cytoskeleton organizationISO
GO:0033209 tumor necrosis factor-mediated signaling pathwayISO
GO:0034446 substrate adhesion-dependent cell spreadingISO
GO:0034446 substrate adhesion-dependent cell spreadingIBA
GO:0042327 positive regulation of phosphorylationISO
GO:0043066 negative regulation of apoptotic processISO
GO:0043406 positive regulation of MAP kinase activityISO
GO:0043410 positive regulation of MAPK cascadeISO
GO:0043491 protein kinase B signalingIMP
GO:0043524 negative regulation of neuron apoptotic processISO
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarityIMP
GO:0045663 positive regulation of myoblast differentiationISO
GO:0045669 positive regulation of osteoblast differentiationIMP
GO:0045773 positive regulation of axon extensionISO
GO:0045893 positive regulation of transcription, DNA-templatedISO
GO:0048662 negative regulation of smooth muscle cell proliferationISO
GO:0048812 neuron projection morphogenesisISO
GO:0050772 positive regulation of axonogenesisISO
GO:0050775 positive regulation of dendrite morphogenesisISO
GO:0051897 positive regulation of protein kinase B signalingISO
GO:0090263 positive regulation of canonical Wnt signaling pathwayISO
GO:0097435 supramolecular fiber organizationISO
GO:1901224 positive regulation of NIK/NF-kappaB signalingISO
GO:2000178 negative regulation of neural precursor cell proliferationIGI
GO:2000178 negative regulation of neural precursor cell proliferationIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmISO
GO:0005737 cytoplasmISO
GO:0005829 cytosolISO
GO:0005886 plasma membraneIEA
GO:0005911 cell-cell junctionISO
GO:0005925 focal adhesionISO
GO:0005925 focal adhesionIDA
GO:0005925 focal adhesionIBA
GO:0030017 sarcomereIEA
GO:0030027 lamellipodiumIDA
GO:0030054 cell junctionISO
GO:0030424 axonISO
GO:0032991 protein-containing complexISO
GO:0043025 neuronal cell bodyISO
GO:0043034 costamereISO
GO:0043195 terminal boutonISO
GO:0043198 dendritic shaftISO
GO:0001725 stress fiberISO
GO:0001725 stress fiberIBA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1500931 Cell-Cell communicationIEA
R-MMU-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesionsIEA
R-MMU-446353 Cell-extracellular matrix interactionsIEA
R-MMU-446728 Cell junction organizationIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0040 ANK repeat
KW-0067 ATP-binding
KW-0965 Cell junction
KW-1003 Cell membrane
KW-0966 Cell projection
KW-0963 Cytoplasm
KW-0418 Kinase
KW-0472 Membrane
KW-0547 Nucleotide-binding
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR035692 PK_ILK
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom

PROSITE

PROSITE ID PROSITE Term
PS50297 ANK_REP_REGION
PS50088 ANK_REPEAT
PS50011 PROTEIN_KINASE_DOM

Pfam

Pfam ID Pfam Term
PF07714 Pkinase_Tyr

Protein-protein interaction

Protein-miRNA interaction