Gene: Ilk

Basic information

Tag Content
Uniprot ID Q99J82
Entrez ID 170922
Genbank protein ID AAH62406.1; AAK12419.1;
Genbank nucleotide ID NM_133409.2
Ensembl protein ID ENSRNOP00000025906
Ensembl nucleotide ID ENSRNOG00000018993
Gene name Integrin-linked protein kinase
Gene symbol Ilk
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Sequence
MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60
NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120
ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180
TLNKHSGIDF KQLNFLAKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 240
RLRIFSHPNV LPVLGACQAP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300
MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360
LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420
VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologILK476836E2R5H4Canis lupus familiarisPredictionMore>>
1:1 orthologILK102177259A0A452F0A3Capra hircusPredictionMore>>
1:1 orthologILK100070066A0A3Q2H733Equus caballusPredictionMore>>
1:1 orthologILKA0A0A0MTH3Homo sapiensPredictionMore>>
1:1 orthologIlk16202O55222CPOMus musculusPublicationMore>>
1:1 orthologILK748941A0A2I3T709Pan troglodytesPredictionMore>>
1:1 orthologIlk170922Q99J82Rattus norvegicusPredictionMore>>
1:1 orthologilk393543Q6PHD6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030424 axon
GO:0005911 cell-cell junction
GO:0043034 costamere
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043198 dendritic shaft
GO:0005925 focal adhesion
GO:0030027 lamellipodium
GO:0043025 neuronal cell body
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0030017 sarcomere
GO:0043195 terminal bouton
GO:0005524 ATP binding
GO:0005178 integrin binding
GO:0019904 protein domain specific binding
GO:0004672 protein kinase activity
GO:0019901 protein kinase binding
GO:0004674 protein serine/threonine kinase activity
GO:0044877 protein-containing complex binding
GO:0017124 SH3 domain binding
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0007569 cell aging
GO:0007050 cell cycle arrest
GO:0030030 cell projection organization
GO:0007160 cell-matrix adhesion
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0010761 fibroblast migration
GO:0007229 integrin-mediated signaling pathway
GO:0032288 myelin assembly
GO:0022011 myelination in peripheral nervous system
GO:0043066 negative regulation of apoptotic process
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:2000178 negative regulation of neural precursor cell proliferation
GO:0043524 negative regulation of neuron apoptotic process
GO:0006469 negative regulation of protein kinase activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0021675 nerve development
GO:0048812 neuron projection morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0045773 positive regulation of axon extension
GO:0050772 positive regulation of axonogenesis
GO:0030513 positive regulation of BMP signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0030335 positive regulation of cell migration
GO:0008284 positive regulation of cell population proliferation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0050775 positive regulation of dendrite morphogenesis
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045663 positive regulation of myoblast differentiation
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:0045669 positive regulation of osteoblast differentiation
GO:0042327 positive regulation of phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0001934 positive regulation of protein phosphorylation
GO:0009967 positive regulation of signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0043491 protein kinase B signaling
GO:0006468 protein phosphorylation
GO:0032956 regulation of actin cytoskeleton organization
GO:0001558 regulation of cell growth
GO:0014044 Schwann cell development
GO:0034446 substrate adhesion-dependent cell spreading
GO:0097435 supramolecular fiber organization
GO:0033209 tumor necrosis factor-mediated signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0040 ANK repeat
KW-0067 ATP-binding
KW-0965 Cell junction
KW-1003 Cell membrane
KW-0966 Cell projection
KW-0963 Cytoplasm
KW-0418 Kinase
KW-0472 Membrane
KW-0547 Nucleotide-binding
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR035692 PK_ILK
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom

PROSITE

PROSITE ID PROSITE Term
PS50297 ANK_REP_REGION
PS50088 ANK_REPEAT
PS50011 PROTEIN_KINASE_DOM

Pfam

Pfam ID Pfam Term
PF07714 Pkinase_Tyr