| Tag | Content |
|---|---|
| Uniprot ID | A0A452DKR2 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000000412 |
| Ensembl nucleotide ID | ENSCHIG00000000294 |
| Gene name | Uncharacterized protein |
| Gene symbol | PHF8 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS 60 IMKKRRVSSK GHDTHKGKPV KTGSPTFIRE LRSRTFDSSD EVILKPTGSQ LTVEFLEENS 120 FSVPILVLKK DGLGMTLPSP SFTVRDVEHY VGSDKEIDVI DVARQADCKM KLGDFVKYYY 180 SGKREKVLNV ISLEFSDTRL SNLVETPKIV RKLSWVENLW PEECIFERPN VQKYCLMSVR 240 DSYTDFHIDF GGTSVWYHVL KGEKIFYLIR PTNANLTLFE CWSSSSNQNE MFFGDQVDKC 300 YKCSVKQGQT LFIPTGWIHA VLTPVDCLAF GGNFLHSLNI EMQLKAYEIE KRLSTADLFK 360 FPNFETICWY VGKHILDIFR GLRENRRHPA SYLVHGGKAL NLAFRAWTKK EALPDHEDEI 420 PETVRTVQLI KDLAREIRLV EDIFQQNVGK TSNIFGLQRI FPAGSIPLTR PAHSTSVSMS 480 RLSLPSKSGS KKKGLKPKEF FKKAERKGKE SSALGPAGQL SYNLMDTYSH QALKTGSSQK 540 AKFNITGTCL NDSDDDSPDL DLDGNEGPLA LLMSNGSTKR VKNLSKSRRA KIVKKADKAR 600 VVSEQVMEDE LDLDSDDELQ IDERLGKEKA TLIIRPKFPR KLPRAKPCSD PNRVREPGEV 660 EFDIEEDYTT DEDLVEGVEG KLGNGSGAGG ILDLLKASRQ VGGPDYAALT EAPASPSTQE 720 AIQGMLCMAN LQSSSSSPAT SSLQAWWTGG QDRSSTSSNS GLGTVSSSPA SQRTPGKRPI 780 KRPAYWKTES EEEEENASLD EQDSLGACFK DAEYTLESRP GGLPPSPSLN PKSSPGQSVV 840 SKGLAISLIL LVPIENGTFK KILLLLLFLL YNIVLVLPYI NMNLPRVYTP KHPVSCIEPR 900 LAIHFLYDII HVLMPFSQII PPSPSPTKSK SLFYTSVSLL LSRIQGYHYH LSKFHIYALV 960 YCIGVFLSGL LHSVFKCILF NG 982 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PHF8 | A0A452DKR2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PHF8 | 23133 | Q9UPP1 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Phf8 | 320595 | Q80TJ7 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 465652 | A0A2I3SKZ5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100520413 | A0A287B7U8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100344764 | G1SHZ3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Phf8 | 317425 | D4AD31 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | phf8 | 566534 | P0CH95 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0031965 | nuclear membrane |
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0003682 | chromatin binding |
| GO:0071558 | histone demethylase activity (H3-K27 specific) |
| GO:0051864 | histone demethylase activity (H3-K36 specific) |
| GO:0032454 | histone demethylase activity (H3-K9 specific) |
| GO:0035575 | histone demethylase activity (H4-K20 specific) |
| GO:0005506 | iron ion binding |
| GO:0035064 | methylated histone binding |
| GO:0008270 | zinc ion binding |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0061188 | negative regulation of chromatin silencing at rDNA |
| GO:0045943 | positive regulation of transcription by RNA polymerase I |