| Tag | Content |
|---|---|
| Uniprot ID | D4AD31 |
| Entrez ID | 317425 |
| Genbank protein ID | EDL86314.1 |
| Genbank nucleotide ID | XM_008773119.1; XM_006256792.2; XM_017602072.1; NM_001108253.1; |
| Ensembl protein ID | ENSRNOP00000040672 |
| Ensembl nucleotide ID | ENSRNOG00000002708 |
| Gene name | PHD finger protein 8 |
| Gene symbol | Phf8 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS 60 IMKKRRGSSK GHDNHKGKPL KTGSSMFIRE LRGRTFDSSD EVILKPTGSQ LTVEFLEENS 120 FSVPILVLKK DGLGMTLPSP SFTVRDVEHY VGSDKEIDVI DVARQADCKM KLGDFVKYYY 180 SGKREKVLNV ISLEFSDTRL SNLVETPKIV RKLSWVENLW PEECVFERPN VQKYCLMSVR 240 DSYTDFHIDF GGTSVWYHVL KGEKIFYLIR PTNANLTLFE CWSSSSNQNE MFFGDQVEKC 300 YKCSVKQGQT LFIPTGWIHA VLTPVDCLAF GGNFLHSLNI EMQLKAYEIE KRLSTADLFK 360 FPNFETICWY VGKHILDIFR GLRENRRHPA SYLVHGGKAL NLAFRAWTRK EALPDHEDEI 420 PETVRTVQLI KDLAREIRLV EDIFQQNVGK TSNIFGLQRI FPAGSIPLTR PAHSTSVSMS 480 KLSLPSKNGS KKKGLKPKDI FKKAERKGKQ SSALGPAGQL SYNLMDPYSH QALKTGPSQK 540 AKLNIGGACL NDSDDDSADM DVDGSENPLA LLMANGSTKR MKSVSKSRRA KIAKKVDSAR 600 LVAEQVMGDE FDLDSDDELQ IDERLGKEKA NLLMRSKFPR KLPRAKPCSD PNRIREPGEV 660 EFDIEEDYTT DEDMVEGVES KLGNGSGAGG ILDLLKASRQ VGGPDYAALT EAPASPSTQE 720 AIQGMLCMAN LQSSSSSPAT SSLQAWWTGG QDRSSGSSSS GLGTVSNSPI SQRTPGKRPI 780 KRPAYWKNES EEEENASMDE QDSLGACFKD AEYIYPSLES DDDDPALKSR PKKKKNSDDA 840 PWSPKARVTP TLPKQDRPVR EGTRVASIET GLAAAAAKLA QQELQKAQKK KYIKKKPLLK 900 EVEQPRPQDS NTTMTMPAPT LATTPQPVTS SSPQPPPEPK QEALSGSLAD HEYTARPNAF 960 GMAQANRSTT PMAPGVFLTQ RRPSVGSQSS QAGQGKRPKK GLATAKQRLG RILKIHRNGK 1020 LLL 1023 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PHF8 | A0A452DKR2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PHF8 | 23133 | Q9UPP1 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Phf8 | 320595 | Q80TJ7 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 465652 | A0A2I3SKZ5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100520413 | A0A287B7U8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100344764 | G1SHZ3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Phf8 | 317425 | D4AD31 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | phf8 | 566534 | P0CH95 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005730 | nucleolus |
| GO:0005634 | nucleus |
| GO:0016706 | 2-oxoglutarate-dependent dioxygenase activity |
| GO:0003682 | chromatin binding |
| GO:0032452 | histone demethylase activity |
| GO:0071558 | histone demethylase activity (H3-K27 specific) |
| GO:0051864 | histone demethylase activity (H3-K36 specific) |
| GO:0032454 | histone demethylase activity (H3-K9 specific) |
| GO:0035575 | histone demethylase activity (H4-K20 specific) |
| GO:0005506 | iron ion binding |
| GO:0035064 | methylated histone binding |
| GO:0008270 | zinc ion binding |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0071557 | histone H3-K27 demethylation |
| GO:0070544 | histone H3-K36 demethylation |
| GO:0033169 | histone H3-K9 demethylation |
| GO:0035574 | histone H4-K20 demethylation |
| GO:0061188 | negative regulation of chromatin silencing at rDNA |
| GO:0045943 | positive regulation of transcription by RNA polymerase I |
| GO:0045893 | positive regulation of transcription, DNA-templated |