| Tag | Content |
|---|---|
| Uniprot ID | P0CH95 |
| Entrez ID | 566534 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005162265.3; NM_001202447.1; |
| Ensembl protein ID | ENSDARP00000148598; ENSDARP00000007140; |
| Ensembl nucleotide ID | ENSDARG00000006584 |
| Gene name | Histone lysine demethylase PHF8 |
| Gene symbol | phf8 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes. |
| Sequence | MASVPVYCLC RLPYDVTRFM IECDVCQDWF HGSCVGVEED KAAEIDLYHC PNCQVTHGPS 60 VMRKRRGAVK HADVGLGRDS GRPVKTGSAQ FVRELRCRTF PSADEVLLKP TGAQLTVEFL 120 EERSFSVPVL VLRKDGLGMN LPPSSFSVTD VEHYIGTEKE IDVIDVSRQA DLKMKLGEFV 180 EYYNSPNRDR VLNVISLEFS DTRLSNLVET PKIVRKLSWV ENLWPEESIF ERPNVQKYCL 240 MGVKDSYTDF HIDFGGTSVW YHVLRGEKIF YLIRPTAANL SLFERWSSSS NQNELFFGDQ 300 VDMCYKCSVK QGNTLFIPTG WIHAVLTPVD CLAFGGNFLH SLNIDMQLRA YEIEKRLSTA 360 DLFKFPNFET VCWYVGKHLL DTFRGLRENR RHPATYLVHG AKALNNAFRG WTRKESLGEH 420 EQEIPDTIKT QQLVKDLAKE IRLVEDIFQQ NIGRSGTPFG GSQGLPSPHP KAQLNTPLTF 480 SQHLSKKRGP KPKEAFGGGG VGPPGAKKKS QKGKEIKTEA GELDLLEIHT KHTLKKFQPG 540 CKVKKSKLEL PDDCLDDFEE KINKSKLKLV LTNGKLQGKK GRAGSANGAG SSLQQFQPHM 600 ATLSDFDSED ELQIDETPPP RRRPSLPSKK KLAGLPRKLP RAKPCSDPHR IREPGEVDFD 660 IEEDYTTDEE MLTMQGVKGG AGGILDLLKA SKQVAGLDSA LSEEAPASPS TRDAIQGMLS 720 MANPPSSSSS SSSSSPLSIS GGGEMMGLMK EKGGREGWMS GVKKSERKAV FQRPGKRPIK 780 RPARHLSDDE SLDEQETLGT CFKDSDYVYP SLESDEEDHV SKSKMKRKRN WDDTPWSPKA 840 RVTPTLPKQE RPVREGARVA SVETGLAAAA AKLAQQEQQK TITKRKYTKK KTPQEKVHST 900 VAQLQHQPDS APVSPPLPSE PPVDCIVEER RVEVYSASLL DHEYTAGPGP FSPGGPRGSG 960 AMAPGVFLTS RRPSLSPQNS SSYSPSAPSP GGLVTPTSAG ACQGKRPKKG LATAKQRLGK 1020 ILKIHRNGKL LL 1032 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PHF8 | A0A452DKR2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PHF8 | 23133 | Q9UPP1 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Phf8 | 320595 | Q80TJ7 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 465652 | A0A2I3SKZ5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100520413 | A0A287B7U8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100344764 | G1SHZ3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Phf8 | 317425 | D4AD31 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | phf8 | 566534 | P0CH95 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005730 | nucleolus |
| GO:0003682 | chromatin binding |
| GO:0032452 | histone demethylase activity |
| GO:0071558 | histone demethylase activity (H3-K27 specific) |
| GO:0051864 | histone demethylase activity (H3-K36 specific) |
| GO:0032454 | histone demethylase activity (H3-K9 specific) |
| GO:0035575 | histone demethylase activity (H4-K20 specific) |
| GO:0046872 | metal ion binding |
| GO:0035064 | methylated histone binding |
| GO:0003712 | transcription coregulator activity |
| GO:0007420 | brain development |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0071557 | histone H3-K27 demethylation |
| GO:0070544 | histone H3-K36 demethylation |
| GO:0033169 | histone H3-K9 demethylation |
| GO:0035574 | histone H4-K20 demethylation |
| GO:0061188 | negative regulation of ribosomal DNA heterochromatin assembly |
| GO:0045943 | positive regulation of transcription by RNA polymerase I |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0060319 | primitive erythrocyte differentiation |
| GO:0006482 | protein demethylation |
| GO:0043523 | regulation of neuron apoptotic process |
| GO:0006357 | regulation of transcription by RNA polymerase II |