| Tag | Content |
|---|---|
| Uniprot ID | G1SHZ3 |
| Entrez ID | 100344764 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002720027.3 |
| Ensembl protein ID | ENSOCUP00000002278 |
| Ensembl nucleotide ID | ENSOCUG00000002629 |
| Gene name | PHD finger protein 8 |
| Gene symbol | PHF8 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS 60 IMKKRRASTK GHDTHKGKPV KTGSPTFIRE LRSRTFDSSD EVILKPTGSQ LTVEFLEENS 120 FSVPILVLKK DGLGMTLPSP SFTVRDVEHY VGSDKEIDVI DVTRQADCKM KLGDFVKYYY 180 SGKREKVLNV ISLEFSDTRL SNLVETPKIV RKLSWVENLW PEDCVFERPN VQKYCLMSVR 240 DSYTDFHIDF GGTSVWYHVL KGEKIFYLIR PTNANLTLFE CWSSSSNQNE MFFGDQVEKC 300 YKCSVKQGQT LFIPTGWIHA VLTPVDCLAF GGNFLHSLNI EMQLKAYEIE KRLSTADLFK 360 FPNFETICWY VGKHILDIFR GLRQNRRHPA SYLVHGGKAL NLAFRAWTRK EALPDHEDEI 420 PETVRTVQLI KDLAREIRLV EDIFQQNVGK TSNIFGLQRI FPAGSIPLNR PAHSTSVSIS 480 RLSLPSKSGS KKKGLKPKEL FKKEEQKGKE SSPLGPAGQL SYNLMDTYNH QALKTGSFQK 540 AKFNIAGTRL NDSEDDSPDL DLDGNESPLA VLMSNGSTKR MKSLPKSRRA KIAKKSEKAR 600 AVTEQMMEDE FDLDSDDELQ IDERLGKEKA TLIIRPKFPR KLPRAKPCSD PNRVREPGEV 660 EFDIEEDYTT DEDMMEGVES KLGNGSGAGG ILDLLKASRQ VGGPDYAALT EAPASPSTQE 720 AIQGMLCMAN LQSSSSSPAT SSLQAWWTGG QDRSSGSSSS GLGTVSNSPA SQRTPGKRPI 780 KRPAYWRTES EEEEENASLD EQDSLGACFK DAEYIYPSLE SDEDDPALKS RPKKKKNSDD 840 APWSPKARVT PTLPKQDRPV REGTRVASIE TGLAAAAAKL AQQELQKAQK KKYIKKKPLL 900 KEVEQPRPQD SNISVTVPAP TLAAVPQLPT SSSPLPPPEP KQEALSGSLA DHEYTARPNA 960 FGMAQANRST TPMAPGVFLT QRRPSVGSQS NQTGQGKRPK KGLATAKQRL GRILKIHRNG 1020 KLLL 1024 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PHF8 | A0A452DKR2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PHF8 | 23133 | Q9UPP1 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Phf8 | 320595 | Q80TJ7 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 465652 | A0A2I3SKZ5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100520413 | A0A287B7U8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | PHF8 | 100344764 | G1SHZ3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Phf8 | 317425 | D4AD31 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | phf8 | 566534 | P0CH95 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031965 | nuclear membrane |
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0003682 | chromatin binding |
| GO:0071558 | histone demethylase activity (H3-K27 specific) |
| GO:0051864 | histone demethylase activity (H3-K36 specific) |
| GO:0032454 | histone demethylase activity (H3-K9 specific) |
| GO:0035575 | histone demethylase activity (H4-K20 specific) |
| GO:0005506 | iron ion binding |
| GO:0035064 | methylated histone binding |
| GO:0008270 | zinc ion binding |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0061188 | negative regulation of chromatin silencing at rDNA |
| GO:0045943 | positive regulation of transcription by RNA polymerase I |