| Tag | Content |
|---|---|
| Uniprot ID | A0A452DRK7 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000002409 |
| Ensembl nucleotide ID | ENSCHIG00000005276 |
| Gene name | Uncharacterized protein |
| Gene symbol | EPHB3 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | ELGCRPPSAR SAPPCLSPSL PVSGPLLLLA PGLFSLVAST ETLMDTKWVT SELAWTSHPE 60 SGWEEVSGYD EAMNPIRTYQ VCNVRESSQN NWLRTGFIWR RDVQRVYVEL KFTVRDCNSI 120 PNIPGSCKET FNLFYYEADS DVASASSPFW MENPYVKVDT IAPDESFSRL DTGRVNTKVR 180 SFGPLSKAGF YLAFQDQGAC MSLISVRAFY KKCASTTAGF ALFPETLTGA EPTSLVIAPG 240 TCIANAVEVS VPLKLYCNGD GEWMVPVGAC TCATGHEPAA KESQCRPCPP GSYKAKQGEG 300 PCLPCPPNSR TTSPAAGICT CHNNFYRADS DSADSACTTV PSPPRGVISN VNETSLILEW 360 SEPRDLGGRD DLLYNVICKK CHGGPGTMTC SRCDDNVEFV PRQLGLTERR VHVSHLLAHT 420 RYTFEVQAVN GVSGKSPLPP RYAAVNITTN QAAPSEVPTL RLHSSSGSSL TLSWAPPERP 480 NGVILDYEMK YFEKSEGIAS TVTSQKNSVQ LDGLRPDARY VVQVRARTVA GYGQYSHPAE 540 FETTSERGSG AQQLQEQLPL IVGSATAGLV FVVAVVVIAV VCLRKQRHSS DSEYTEKLQQ 600 YIAPGMKVYI DPFTYEDPNE AVREFAKEID VSCVKIEEVI GAGEFGEVCR GRLKQPGRRE 660 VFVAIKTLKV GYTERQRRDF LSEASIMGQF DHPNIIRLEG VVTKSRPVMI LTEFMENCAL 720 DSFLRLNDGQ FTVIQLVGML RGIAAGMKYL SEMNYVHRDL AARNILVNSN LVCKVSDFGL 780 SRFLEDDPSD PTYTSSLGGK IPIRWTAPEA IAYRKFTSAS DVWSYGIVMW EVMSYGERPY 840 WDMSNQDVIN AVEQDYRLPP PMDCPTALHQ LMLDCWVRDR NLRPKFSQIV NTLDKLIRNA 900 ASLKVIASAQ SGMSQPLLDR TVPDYTTFTT VGDWLDAIKM GRYKESFVSA GFASFDLVAQ 960 MTAEDLLRIG VTLAGHQKKI LSSIQDMRLQ MNQTLPVQV 999 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EPHB3 | 540907 | F1ML02 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EPHB3 | A0A452DRK7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | EPHB3 | 2049 | P54753 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ephb3 | 13845 | P54754 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EPHB3 | A0A2I3TIH1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Ephb3 | 287989 | D3ZH39 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0005524 | ATP binding |
| GO:0008046 | axon guidance receptor activity |
| GO:0005003 | ephrin receptor activity |
| GO:0001525 | angiogenesis |
| GO:0007413 | axonal fasciculation |
| GO:0016477 | cell migration |
| GO:0021952 | central nervous system projection neuron axonogenesis |
| GO:0022038 | corpus callosum development |
| GO:0060997 | dendritic spine morphogenesis |
| GO:0048546 | digestive tract morphogenesis |
| GO:0051965 | positive regulation of synapse assembly |
| GO:0046777 | protein autophosphorylation |
| GO:0050770 | regulation of axonogenesis |
| GO:0022407 | regulation of cell-cell adhesion |
| GO:0043087 | regulation of GTPase activity |
| GO:0031290 | retinal ganglion cell axon guidance |
| GO:0060021 | roof of mouth development |
| GO:0034446 | substrate adhesion-dependent cell spreading |
| GO:0048538 | thymus development |
| GO:0001655 | urogenital system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR027936 | Eph_TM |
| IPR034245 | EphB3_rcpt_lig-bd |
| IPR001090 | Ephrin_rcpt_lig-bd_dom |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR008979 | Galactose-bd-like_sf |
| IPR013783 | Ig-like_fold |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001660 | SAM |
| IPR013761 | SAM/pointed_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR011641 | Tyr-kin_ephrin_A/B_rcpt-like |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016257 | Tyr_kinase_ephrin_rcpt |
| IPR001426 | Tyr_kinase_rcpt_V_CS |