| Tag | Content |
|---|---|
| Uniprot ID | F1ML02 |
| Entrez ID | 540907 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001192796.1 |
| Ensembl protein ID | ENSBTAP00000006988 |
| Ensembl nucleotide ID | ENSBTAG00000005313 |
| Gene name | EPH receptor B3 |
| Gene symbol | EPHB3 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MARARPPPLP PLPPGLLPLL SPLLLLPLLL PAGCRALEET LMDTKWVTSE LAWTSHPESG 60 WEEVSGYDEA MNPIRTYQVC NVRESSQNNW LRTGFIWRRD VQRVYVELKF TVRDCNSIPN 120 IPGSCKETFN LFYYEADSDV ASASSPFWME NPYVKVDTIA PDESFSRLDA GRVNTKVRSF 180 GPLSKAGFYL AFQDQGACMS LISVRAFYKK CASTTAGFAL FPETLTGAEP TSLVIAPGTC 240 IANAVEVSVP LKLYCNGDGE WMVPVGACTC ATGHEPAAKE SQCRPCPPGS YKAKQGEGPC 300 LPCPPNSRTT SPAAGICTCH NNFYRADSDS ADSACTTVPS PPRGVISNVN ETSLILEWSE 360 PRDLGGRDDL LYNVICKKCH GGPGTMTCSR CDDNVEFVPR QLGLTERRVH VSHLLAHTRY 420 TFEVQAVNGV SGKSPLPPRY AAVNITTNQA APSEVPTLRL HSSSGSSLTL SWAPPERPNG 480 VILDYEMKYF EKSEGIASTV TSQKNSVQLD GLRPDARYVV QVRARTVAGY GQYSHPAEFE 540 TTSERGSGAQ QLQEQLPLIV GSATAGLVFV VAVVVIAVVC LRKQRHSSDS EYTEKLQQYI 600 APGMKVYIDP FTYEDPNEAV REFAKEIDVS CVKIEEVIGA GEFGEVCRGR LKQPGRREVF 660 VAIKTLKVGY TERQRRDFLS EASIMGQFDH PNIIRLEGVV TKSRPVMILT EFMENCALDS 720 FLRLNDGQFT VIQLVGMLRG IAAGMKYLSE MNYVHRDLAA RNILVNSNLV CKVSDFGLSR 780 FLEDDPSDPT YTSSLGGKIP IRWTAPEAIA YRKFTSASDV WSYGIVMWEV MSYGERPYWD 840 MSNQDVINAV EQDYRLPPPM DCPTALHQLM LDCWVRDRNL RPKFSQIVNT LDKLIRNAAS 900 LKVIASAQSG MSQPLLDRTV PDYTTFTTVG DWLDAIKMGR YKESFVSAGF ASFDLVAQMT 960 AEDLLRIGVT LAGHQKKILS SIQDMRLQMN QTLPVQV 997 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EPHB3 | 540907 | F1ML02 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EPHB3 | A0A452DRK7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | EPHB3 | 2049 | P54753 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ephb3 | 13845 | P54754 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EPHB3 | A0A2I3TIH1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Ephb3 | 287989 | D3ZH39 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0008046 | axon guidance receptor activity |
| GO:0005003 | ephrin receptor activity |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0001525 | angiogenesis |
| GO:0007413 | axonal fasciculation |
| GO:0016477 | cell migration |
| GO:0021952 | central nervous system projection neuron axonogenesis |
| GO:0022038 | corpus callosum development |
| GO:0060997 | dendritic spine morphogenesis |
| GO:0048546 | digestive tract morphogenesis |
| GO:0007275 | multicellular organism development |
| GO:0033674 | positive regulation of kinase activity |
| GO:0051965 | positive regulation of synapse assembly |
| GO:0046777 | protein autophosphorylation |
| GO:0050770 | regulation of axonogenesis |
| GO:0022407 | regulation of cell-cell adhesion |
| GO:0043087 | regulation of GTPase activity |
| GO:0031290 | retinal ganglion cell axon guidance |
| GO:0060021 | roof of mouth development |
| GO:0034446 | substrate adhesion-dependent cell spreading |
| GO:0048538 | thymus development |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0001655 | urogenital system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR027936 | Eph_TM |
| IPR034245 | EphB3_rcpt_lig-bd |
| IPR001090 | Ephrin_rcpt_lig-bd_dom |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR008979 | Galactose-bd-like_sf |
| IPR013783 | Ig-like_fold |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001660 | SAM |
| IPR013761 | SAM/pointed_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR011641 | Tyr-kin_ephrin_A/B_rcpt-like |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016257 | Tyr_kinase_ephrin_rcpt |
| IPR001426 | Tyr_kinase_rcpt_V_CS |