| Tag | Content |
|---|---|
| Uniprot ID | D3ZH39 |
| Entrez ID | 287989 |
| Genbank protein ID | EDL78031.1 |
| Genbank nucleotide ID | NM_001105868.1 |
| Ensembl protein ID | ENSRNOP00000039489 |
| Ensembl nucleotide ID | ENSRNOG00000031801 |
| Gene name | Eph receptor B3 |
| Gene symbol | Ephb3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAGARPPPGL LPLLAPLLLP LLLPAGCRAL EETLMDTKWV TSELAWTSHP ESGWEEVSGY 60 DEAMNPIRTY QVCNVRESSQ NNWLRTGFIW RREVQRVYVE LKFTVRDCNS IPNIPGSCKE 120 TFNLFYYEAD SDVASASSPF WMENPYVKVD TIAPDESFSR LDAGRVNTKV RSFGPLSKAG 180 FYLAFQDQGA CMSLISVRAF YKKCASTTAG FALFPETLTG AEPTSLVIAP GTCIANAVEV 240 SVPLKLYCNG DGEWMVPVGA CTCATGHEPA AKETQCRACP PGSYKAKQGE GPCLPCPPNS 300 RTTSPAASIC TCHNNFYRAD SDTADSACTT VPSPPRGVIS NVNETSLILE WSEPRDLGGR 360 DDLLYNVICK KCRGSSGAGG PATCSRCDDN VEFEPRQLGL TERRVHISHL LAHTRYTFEV 420 QAVNGVSGKS PLPPRYAAVN ITTNQAAPSE VPTLHLHSSS GSSLTLSWAP PERPNGVILD 480 YEMKYFEKSK GIASTVTSQK NSVQLDGLQP DARYVVQVRA RTVAGYGQYS RPAEFETTSE 540 RGSGAQQLQE QLPLIVGSTV AGFVFMVVVV VIALVCLRKQ RQGPDAEYTE KLQQYVAPRM 600 KVYIDPFTYE DPNEAVREFA KEIDVSCVKI EEVIGAGEFG EVCRGRLKLP GRREVFVAIK 660 TLKVGYTERQ RRDFLSEASI MGQFDHPNII RLEGVVTKSR PVMILTEFME NCALDSFLRL 720 NDGQFTVIQL VGMLRGIAAG MKYLSEMNYV HRDLAARNIL VNSNLVCKVS DFGLSRFLED 780 DPSDPTYTSS LGGKIPIRWT APEAIAYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMSNQ 840 DVINAVEQDY RLPPPMDCPT ALHQLMLDCW VRDRNLRPKF SQIVNTLDKL IRNAASLKVI 900 ASAPSGMSQP LLDRTVPDYT TFTTVGDWLD AIKMGRYKES FVGAGFASFD LVAQMTAEDL 960 LRIGVTLAGH QKKILSSIQD MRLQMNQTLP VQEVCPKPLH IEDGLEEGVI SPPQMPQGPG 1020 LPALQSGIFT TQIWLCFSSG GPGRVGWG 1048 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EPHB3 | 540907 | F1ML02 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EPHB3 | A0A452DRK7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | EPHB3 | 2049 | P54753 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ephb3 | 13845 | P54754 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | EPHB3 | A0A2I3TIH1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Ephb3 | 287989 | D3ZH39 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0008046 | axon guidance receptor activity |
| GO:0005003 | ephrin receptor activity |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0001525 | angiogenesis |
| GO:0007411 | axon guidance |
| GO:0007413 | axonal fasciculation |
| GO:0016477 | cell migration |
| GO:0021952 | central nervous system projection neuron axonogenesis |
| GO:0022038 | corpus callosum development |
| GO:0060996 | dendritic spine development |
| GO:0060997 | dendritic spine morphogenesis |
| GO:0048546 | digestive tract morphogenesis |
| GO:0048013 | ephrin receptor signaling pathway |
| GO:0007275 | multicellular organism development |
| GO:0033674 | positive regulation of kinase activity |
| GO:0051965 | positive regulation of synapse assembly |
| GO:0046777 | protein autophosphorylation |
| GO:0050770 | regulation of axonogenesis |
| GO:0022407 | regulation of cell-cell adhesion |
| GO:0043087 | regulation of GTPase activity |
| GO:0031290 | retinal ganglion cell axon guidance |
| GO:0060021 | roof of mouth development |
| GO:0034446 | substrate adhesion-dependent cell spreading |
| GO:0048538 | thymus development |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0001655 | urogenital system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR027936 | Eph_TM |
| IPR034245 | EphB3_rcpt_lig-bd |
| IPR001090 | Ephrin_rcpt_lig-bd_dom |
| IPR003961 | FN3_dom |
| IPR036116 | FN3_sf |
| IPR008979 | Galactose-bd-like_sf |
| IPR013783 | Ig-like_fold |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001660 | SAM |
| IPR013761 | SAM/pointed_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR011641 | Tyr-kin_ephrin_A/B_rcpt-like |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016257 | Tyr_kinase_ephrin_rcpt |
| IPR001426 | Tyr_kinase_rcpt_V_CS |