Gene: TM7SF2

Basic information

Tag Content
Uniprot ID A0A452DYK9
Entrez ID 100861120
Genbank protein ID
Genbank nucleotide ID XM_005699882.3
Ensembl protein ID ENSCHIP00000004851
Ensembl nucleotide ID ENSCHIG00000008956
Gene name Uncharacterized protein
Gene symbol TM7SF2
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAPPQGSRAP LEFGGPLGAA ALMLLLPVTM FHLLLVARSG PARLLGPPPY LPGLEELWSP 60
WALLLCLTWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVALGVSAG 120
LPLSALPEML LPLAFAATLT AFIFSLLLYL KALVAPASAL APGGNSGNLI YDFFLGRELN 180
PRICSFDFKY FCELRPGLIG WVLINLALLM QEAELRGSPS LAMWLVNGFQ LLYVADALWY 240
EEAVLTTMDI IHDGFGFMLA FGDLAWVPFT YSLQAQFLLY HPQPLGWPLA SFICLINAVG 300
YYIFRGANSQ KNTFRKNPSD PRVADLETIS TATGRRLLVS GWWGMVRHPN YLGDLIMALA 360
WSLPCGVFHL LPYFYFLYFT ALLVHREDRD ERQCLQKYGL AWHEYCRRVP YRIVPYVY 418

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTM7SF2282384Q17QS8Bos taurusPredictionMore>>
1:1 orthologTM7SF2476027A0A5F4DIJ7Canis lupus familiarisPredictionMore>>
1:1 orthologTM7SF2100861120A0A452DYK9Capra hircusPredictionMore>>
1:1 orthologTM7SF27108O76062Homo sapiensPredictionMore>>
1:1 orthologTm7sf273166Q71KT5CPOMus musculusPublicationMore>>
1:1 orthologTM7SF2451314K6ZIY4Pan troglodytesPredictionMore>>
1:1 ortholog100514510A0A480QTI0Sus scrofaPredictionMore>>
1:1 orthologTm7sf2293688Q5BK21Rattus norvegicusPredictionMore>>
1:1 orthologtm7sf2F1Q8Y4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
GO:0043235 receptor complex
GO:0050613 delta14-sterol reductase activity
GO:0006695 cholesterol biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0472 Membrane
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR001171 Ergosterol_biosynth_ERG4_ERG24
IPR018083 Sterol_reductase_CS

PROSITE

PROSITE ID PROSITE Term
PS01017 STEROL_REDUCT_1
PS01018 STEROL_REDUCT_2

Pfam

Pfam ID Pfam Term
PF01222 ERG4_ERG24