Gene: NCOR2

Basic information

Tag Content
Uniprot ID A0A452E1G4
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000005839
Ensembl nucleotide ID ENSCHIG00000009383
Gene name Uncharacterized protein
Gene symbol NCOR2
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARPGTDVRLG PPSEFSFDVG LLEYPHHPRD 60
YTSHLSPGSI IQPQRRRPSL LSEFQPGNER SQELHLRPES HSYLPELGKS EMEFLESKRP 120
RLELLPDPLL RPSPLLAAGQ PGGSEDLSKD RSLTGKLEPV SPPSPPHADP ELELVPPRLS 180
KEELIQNMDR VDREITMVEQ QISKLKKKQQ QLEEEAAKPP EPEKPVSPPP IESKHRSLVQ 240
IIYDENRVCP ILSFIAPPLY NQPSDTRQYH ENIKINQAMR KKLILYFKRR NHARKQWEQK 300
FCQRYDQLME AWEKKVERIE NNPRRRAKES KVREYYEKQF PEIRKQRELQ ERMQSRVGQR 360
GSGLSMSAAR SEHEVSEIID GLSEQENLEK QMRQLAVIPP MLYDADQQRI KFINMNGLMD 420
DPMKVYKDRQ VMNMWSEQEK ETFREKFMQH PKNFGLIASF LERKTVAECV LYYYLTKKNE 480
NYKSLVRRSY RRRGKSQQQQ QQQQQQQQMP RSSQEEKDEK EKEKEVEKEE EKPDVENDKE 540
ELIKEKTDDT SGEDNDEKEA VTSKGRKTAN SQGRRKGRIT RSMANEANSE EAVTPQQSAE 600
LASMEMNESS RWTEEEMETA KKGLLEHGRN WSAIARMVGS KTVSQCKNFY FNYKKRQNLD 660
EILQQHKLKM EKERNARRKK KKAPAAASEE AAFPPVVEDE EMEASGVSGN EEEMAEEAEA 720
AVNNSSDTES VPSPRTEAAK DMGQNGPKPP PAPGTDAPPP EPPTPPPEDT PAPTEPTPAP 780
EATSPPTPPP ATQSPATPPP VVPKEEKEEE AAAAPSTEEG EEPKPPVAPE LAADVGKAKM 840
EEPGESHPVE PVKSECEEEA AGEGPDKVKA GQEAAVEAPP EGALKVEKKE ASGSGAKGPA 900
AKGSGAPQDS DSSATCSADE VDEPEGGDKN RLLSPRPSLL TPTSDTRTNA SPQKPLDLKQ 960
LKQRAAAIPP IQVTKVHESP REEAAPSKPA PPAPPPSQHL QPESDTPQPP SSSPRGKSRS 1020
PVPPAEKEAE KPVFFPAFAA EGQKLPADPS CWTSGLPFPV PPREVIKASP HAPDPLAFSY 1080
APPGHPLPLG LHDSARPVLP RPPTISNPPP LISSTKHPSV LERQMGAISQ GMSVQLHVPY 1140
SEHAKAPVGP IAMGLPLAMD PKKLAPFSGV KQEQLSPRGQ AGPPESLGVP TAQETSVLRG 1200
TSLGSVPGGS ITKGTPSTRV PSESPITYRG SITHGTPADV LYKGTITRII GEDSPSRLDR 1260
SREDGLPKGH VIYEGKKGHV LSYEGGMSVS QCSKEDGRSS SGPPHETAAP KRTYDMMEGR 1320
VSRAISSASI EGLMGRAIPP ERHSPHHLKE QHHIRGSITQ GIPRSYVEAQ EDYQRREAKL 1380
LKREGTPPPP PPPPRDLAEA YKARPLEALG PLKLKPAHEG LVATVKEAGR SIHEIPREEL 1440
RRTPELPLAP RPLKEGSITQ GTPLKYDTST SSTGSKKHDV RSIIGSPGRT FPAVHPLDVM 1500
ADTRALERVC YEESLKSRTG AVSSSGGSIT RGAPVIVPEL GKPRQSPLTY EDHAAPFAGH 1560
LPRGSPVTTR EPTPRLQEGS LSSSKASQDR KLTSTPREIA KSPHSSVPEH HPHPISPYEH 1620
LLRGVSGVDL YRGHIPLAFD PTSIPRGIPL DAAAAYYLPR HLAPNPTYPH LYPPYLIRGY 1680
PDTAALENRQ TIINDYITSQ QMHHNAATAM AQRADMLRGL SPRESSLALN YATGPRGIID 1740
LSQVPHLPVL VPPTPGTPAT AMDRLAYLPT APQHFSSRLS SSPLSPGGPT HLTKPTATSS 1800
TERERERERE REREREREKS ILTSTTTVEH APIWRPGTEQ SGGGGAGGSG GGGGSSSSRP 1860
ASHSHAHQHS PISPRTQDAI QQRPSVLHNT GMKSIITSVE PSTPTVLRST STSSPVRPAA 1920
TFPPATHCPL GGTLDGVYPP LMEPVLLPKE APRVARPERP RADAGHTFLA KPPARAGLEP 1980
ASSPGKGSEP RPLAPPGSSH AAIARAPAKS LASHHASPDQ PAPPASAADL HREKTQSKPF 2040
SIQELELRSL GYHGGSYSPD GVEPVSPVSS PSLTHDKGLP KQLEELDKSH LEGDLRHKQP 2100
GPGKLSGEAA HLPHLRPLPE SQPSSSPLLQ TTPGVKGHQR VVTLAQHISE VITQDYTRHH 2160
PQQLSAPLPA PLYSFPGASC PVLDLRRPPS DLYLPPPDHG TQARGSPHSE GGKRSPEPSK 2220
TSAPGSGEDG IEPVSPPEGM VEPGHLRGTM YPLLYRDGEQ AEPRMGSKSP GNTSQPPAFF 2280
SKLTESNSAM VKSKKQEINK KLNTHNRNEP EYNIGQPGTE IFNMPAITGA GLMTCRSQAV 2340
QEHASTNMGL EAIIRKALMG GGGKAKVSGR PSSRKAKSPA PGLASGDRPP SVSSVHSEGD 2400
CNRRTPLTNR VWEDRPSSAG STPFPYNPLI MRLQAGVMAS PPPPGLPAGS GPLAGPHHAW 2460
DEEPKPLLCS QYETLSDSE 2479

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNCOR2A0A452E1G4Capra hircusPredictionMore>>
1:1 orthologNCOR29612Q9Y618Homo sapiensPredictionMore>>
1:1 orthologNcor220602Q9WU42CPOMus musculusPublicationMore>>
1:1 orthologNCOR2H2RC84Pan troglodytesPredictionMore>>
1:1 orthologNcor2360801D3ZXN9Rattus norvegicusPredictionMore>>
1:1 orthologncor2F1R8Z8Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016604 nuclear body
GO:0000790 nuclear chromatin
GO:0016363 nuclear matrix
GO:0017053 transcriptional repressor complex
GO:0003677 DNA binding
GO:0042826 histone deacetylase binding
GO:0005112 Notch binding
GO:0047485 protein N-terminus binding
GO:0003714 transcription corepressor activity
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0010565 regulation of cellular ketone metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom

PROSITE

PROSITE ID PROSITE Term
PS51293 SANT

Pfam

Pfam ID Pfam Term
PF15784 GPS2_interact
PF00249 Myb_DNA-binding