| Tag | Content |
|---|---|
| Uniprot ID | Q9WU42; E9Q9V0; Q9WU43; Q9WUC1; |
| Entrez ID | 20602 |
| Genbank protein ID | AAD20944.1; AAD22972.1; AAD20945.1; |
| Genbank nucleotide ID | NM_001253905.1; XM_011240831.2; NM_001253904.1; |
| Ensembl protein ID | ENSMUSP00000107029; ENSMUSP00000107025; |
| Ensembl nucleotide ID | ENSMUSG00000029478 |
| Gene name | Nuclear receptor corepressor 2 |
| Gene symbol | Ncor2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17928865 |
| Functional description | Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. |
| Sequence | MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARSHTDVGLL EYQHHPRDYT SHLSPGSIIQ 60 PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI EFTESKRPRL ELLPDTLLRP 120 SPLLATGQPS GSEDLTKDRS LAGKLEPVSP PSPPHADPEL ELAPSRLSKE ELIQNMDRVD 180 REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA 240 AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ 300 RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG 360 LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM 420 KVYKDRQVTN MWSEQERDTF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK 480 SLVRRSYRRR GKSQQQQQQQ QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE 540 LSKEKTDDTS GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL 600 ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF NYKKRQNLDE 660 ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE MEASGASANE EELAEEAEAS 720 QASGNEVPRV GECSGPAAVN NSSDTESVPS PRSEATKDTG PKPTGTEALP AATQPPVPPP 780 EEPAVAPAEP SPVPDASGPP SPEPSPSPAA PPATVDKDEQ EAPAAPAPQT EDAKEQKSEA 840 EEIDVGKPEE PEASEEPPES VKSDHKEETE EEPEDKAKGT EAIETVSEAP LKVEEAGSKA 900 AVTKGSSSGA TQDSDSSATC SADEVDEPEG GDKGRLLSPR PSLLTPAGDP RASTSPQKPL 960 DLKQLKQRAA AIPPIVTKVH EPPREDTVPP KPVPPVPPPT QHLQPEGDVS QQSGGSPRGK 1020 SRSPVPPAEK EAEKPAFFPA FPTEGPKLPT EPPRWSSGLP FPIPPREVIK TSPHAADPSA 1080 FSYTPPGHPL PLGLHDSARP VLPRPPISNP PPLISSAKHP GVLERQLGAI SQQGMSVQLR 1140 VPHSEHAKAP MGPLTMGLPL AVDPKKLGTA LGSATSGSIT KGLPSTRAAD GPSYRGSITH 1200 GTPADVLYKG TISRIVGEDS PSRLDRARED TLPKGHVIYE GKKGHVLSYE GGMSVSQCSK 1260 EDGRSSSGPP HETAAPKRTY DMMEGRVGRT VTSASIEGLM GRAIPEQHSP HLKEQHHIRG 1320 SITQGIPRSY VEAQEDYLRR EAKLLKREGT PPPPPPPRDL TETYKPRPLD PLGPLKLKPT 1380 HEGVVATVKE AGRSIHEIPR EELRRTPELP LAPRPLKEGS ITQGTPLKYD SGAPSTGTKK 1440 HDVRSIIGSP GRPFPALHPL DIMADARALE RACYEESLKS RSGTSSGAGG SITRGAPVVV 1500 PELGKPRQSP LTYEDHGAPF TSHLPRGSPV TTREPTPRLQ EGSLLSSKAS QDRKLTSTPR 1560 EIAKSPHSTV PEHHPHPISP YEHLLRGVTG VDLYRGHIPL AFDPTSIPRG IPLEAAAAAY 1620 YLPRHLAPSP TYPHLYPPYL IRGYPDTAAL ENRQTIINDY ITSQQMHHNA ASAMAQRADM 1680 LRGLSPRESS LALNYAAGPR GIIDLSQVPH LPVLVPPTPG TPATAIDRLA YLPTAPPPFS 1740 SRHSSSPLSP GGPTHLAKPT ATSSSERERE RERERDKSIL TSTTTVEHAP IWRPGTEQSS 1800 GAGGSSRPAS HTHQHSPISP RTQDALQQRP SVLHNTSMKG VVTSVEPGTP TVLRWARSTS 1860 TSSPVRPAAT FPPATHCPLG GTLEGVYPTL MEPVLLPKET SRVARPERPR VDAGHAFLTK 1920 PPAREPASSP SKSSEPRSLA PPSSSHTAIA RTPAKNLAPH HASPDPPAPT SASDLHREKT 1980 QSKPFSIQEL ELRSLGYHSG AGYSPDGVEP ISPVSSPSLT HDKGLSKPLE ELEKSHLEGE 2040 LRHKQPGPMK LSAEAAHLPH LRPLPESQPS SSPLLQTAPG IKGHQRVVTL AQHISEVITQ 2100 DYTRHHPQQL SGPLPAPLYS FPGASCPVLD LRRPPSDLYL PPPDHGTPAR GSPHSEGGKR 2160 SPEPSKTSVL GSSEDAIEPV SPPEGMTEPG HARSTAYPLL YRDGEQGEPR MGSKSPGNTS 2220 QPPAFFSKLT ESNSAMVKSK KQEINKKLNT HNRNEPEYNI GQPGTEIFNM PAITGAGLMT 2280 CRSQAVQEHA STNMGLEAII RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT 2340 ADGRSDHALT SPGGGGKAKV SGRPSSRKAK SPAPGLASGD RPPSVSSVHS EGDCNRRTPL 2400 TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH HAWDEEPKPL 2460 LCSQYETLSD SE 2472 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NCOR2 | A0A452E1G4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NCOR2 | 9612 | Q9Y618 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ncor2 | 20602 | Q9WU42 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NCOR2 | H2RC84 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Ncor2 | 360801 | D3ZXN9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ncor2 | F1R8Z8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001012 | RNA polymerase II regulatory region DNA binding | ISO |
| GO:0001012 | RNA polymerase II regulatory region DNA binding | IBA |
| GO:0003677 | DNA binding | IDA |
| GO:0003682 | chromatin binding | ISO |
| GO:0003682 | chromatin binding | IDA |
| GO:0003682 | chromatin binding | IBA |
| GO:0003714 | transcription corepressor activity | ISO |
| GO:0003714 | transcription corepressor activity | IMP |
| GO:0003714 | transcription corepressor activity | IGI |
| GO:0003714 | transcription corepressor activity | IDA |
| GO:0003714 | transcription corepressor activity | IBA |
| GO:0005112 | Notch binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0016922 | nuclear receptor binding | ISO |
| GO:0035257 | nuclear hormone receptor binding | IBA |
| GO:0035259 | glucocorticoid receptor binding | ISO |
| GO:0042826 | histone deacetylase binding | ISO |
| GO:0042826 | histone deacetylase binding | IBA |
| GO:0042974 | retinoic acid receptor binding | ISO |
| GO:0043565 | sequence-specific DNA binding | IDA |
| GO:0043565 | sequence-specific DNA binding | IBA |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0046965 | retinoid X receptor binding | ISO |
| GO:0047485 | protein N-terminus binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0003007 | heart morphogenesis | IGI |
| GO:0003007 | heart morphogenesis | IMP |
| GO:0010565 | regulation of cellular ketone metabolic process | ISO |
| GO:0021537 | telencephalon development | IMP |
| GO:0021846 | cell proliferation in forebrain | IMP |
| GO:0030900 | forebrain development | IMP |
| GO:0042593 | glucose homeostasis | IMP |
| GO:0045599 | negative regulation of fat cell differentiation | IMP |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | IDA |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP |
| GO:0050872 | white fat cell differentiation | IMP |
| GO:0060509 | type I pneumocyte differentiation | IGI |
| GO:0060509 | type I pneumocyte differentiation | IMP |
| GO:0060766 | negative regulation of androgen receptor signaling pathway | ISO |
| GO:0090312 | positive regulation of protein deacetylation | IDA |
| GO:1903799 | negative regulation of production of miRNAs involved in gene silencing by miRNA | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000118 | histone deacetylase complex | IDA |
| GO:0000118 | histone deacetylase complex | IBA |
| GO:0000785 | chromatin | ISO |
| GO:0000790 | nuclear chromatin | ISO |
| GO:0000790 | nuclear chromatin | IBA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0016363 | nuclear matrix | ISS |
| GO:0016363 | nuclear matrix | ISO |
| GO:0016604 | nuclear body | ISO |
| GO:0016604 | nuclear body | IDA |
| GO:0017053 | transcriptional repressor complex | ISO |
| GO:0017053 | transcriptional repressor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-170834 | Signaling by TGF-beta Receptor Complex | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | IEA |
| R-MMU-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | IEA |
| R-MMU-350054 | Notch-HLH transcription pathway | IEA |
| R-MMU-383280 | Nuclear Receptor transcription pathway | IEA |
| R-MMU-400206 | Regulation of lipid metabolism by PPARalpha | IEA |
| R-MMU-556833 | Metabolism of lipids | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| R-MMU-9006936 | Signaling by TGF-beta family members | IEA |
| R-MMU-9024446 | NR1H2 and NR1H3-mediated signaling | IEA |
| R-MMU-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | IEA |
| R-MMU-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51293 | SANT |