| Tag | Content |
|---|---|
| Uniprot ID | D3ZXN9 |
| Entrez ID | 360801 |
| Genbank protein ID | EDM13562.1 |
| Genbank nucleotide ID | NM_001108334.1 |
| Ensembl protein ID | ENSRNOP00000001334 |
| Ensembl nucleotide ID | ENSRNOG00000001004 |
| Gene name | Nuclear receptor co-repressor 2 |
| Gene symbol | Ncor2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARPHTDVGLL EYQHHPRDYT SHLSPGSIIQ 60 PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI EFTESKRPRL ELLPDTLLRP 120 APLLATGQPS GSEDLTKDRS LAGKLEPVSP PSPPHADPEL ELTPSRLSKE ELIQNMDRVD 180 REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA 240 AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ 300 RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG 360 LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM 420 KVYKDRQVTN MWSEQERDTF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK 480 SLVRRSYRRR GKSQQQQQQQ QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE 540 LSKEKTDDTS GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL 600 ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF NYKKRQNLDE 660 ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE MEASGASANE EELAEEAEAS 720 QASGNEVPRV GECSGPAAVN NSSDTESVPS PRTEATKDAG PKPASTEALP AATQPPVPPP 780 EEPATVPDEP CPAPDASGPP SPVASPPPAA PPAAVDKDEQ DQAATVPQTE DAKEQKSEAE 840 ELVIDVGKTE EPEAPEEPPE SVKSDHKEET EEEPEDKAKG PEAIETVSEA PLKVEEAGSK 900 AAVTKGSSSG ATQDSDSSAT CSADEVDEPE GGDKGRLLSP RPSLLTPAGD PRASTSPQKP 960 LDLKQLKQRA AAIPPIVTKV HEPPREDTVP PKPAPPVPPP TQHLQPEGDV SQQSGGSPRG 1020 KCRSPVPPAE KEAEKASFFP AFPAEGPKLP TEPPRWTSGL PFPIPPREVI KTSPHAADPS 1080 AFSYTPPGHP LPLGLHDSAR PVLPRPPISN PPPLISSAKH PGVLERQLGT ISQQGMSVQL 1140 RVPHSEHAKA PMGPLTMGLP LAVDPKKLGT ALGSTASGSI TKGLPSTRTA DGPSYRGSIT 1200 HGTPADVLYK GTISRIVGED SPSRLDRARE DTLPKGHVIY EGKKGHVLSY EGGMSVSQCS 1260 KEDGRSSSGP PHETAAPKRT YDMMEGRVGR TITSASIEGL MGRAIPEQHS PHLKEQHHIR 1320 GSITQGIPRS YVEAQEDYLR REAKLLKREG TPPPPPPPRD LTETYKTRPL DPLGPLKLKP 1380 THEGVVATVK EAGRSIHEIP REELRRTPEL PLAPRPLKEG SITQGTPLKY DSGVPSSGSK 1440 KHDVRSIIGS PGRPFPALHP LDIMADARAL ERACYEESLK SRSGTSSGAG GSITRGAPVV 1500 VPELGKPRQS PLAYEDHGAP FTSHLPRGSP VTTREPTPRL QEGSLLSSKA SQDRKLTSTP 1560 REIAKSPHST VPEHHPHPIS PYEHLLRGVT GVDLYRGHIP LAFDPTSIPR GIPLEAAAAA 1620 YYLPRHLAPS PTYPHLYPPY LIRGYPDTAA LENRQTIIND YITSQQMHHN AASAMAQRAD 1680 MLRGLSPRES SLALNYAAGP RGIIDLSQVP HLPVLVPPTP GTPATAIDRL AYLPTAPPPF 1740 SSRHSSSPLS PGGPTHLAKP TATSSSERER ERERERDKSI LTSTTTVEHA PIWRPGTEQS 1800 SGAGGSSRPA SHTHQHSPIS PRTQDALQQR PSVLHNTSMK GVVTSVEPGT PTVLRWARST 1860 STSSPVRPAA TFPPATHCPL GGTLEGVYPT LMEPVLLPKE TSRVTRPERP RVDAGHAFLT 1920 KPPAREPASS PSKSSEPRSL APPSSSHTAI ARTPAKSLAP HHASPDLPAP TSASDLHREK 1980 TQSKPFSIQE LELRSLGYHS GAGYSPDGVE PISPVSSPSL THDKGLSKPL EELEKSHLEG 2040 ELRHKQPGPM KLSGEAAHLP HLRPLPESQP SSSPLLQTAP GIKGHQRVVT LAQHISEVIT 2100 QDYTRHHPQQ LSGPLPAPLY SFPGASCPVL DLRRPPSDLY LPPPDHGTPA RGSPHSEGGK 2160 RSPEPSKTVL SSSEDAIEPV SPPEGMTEPG HARSTAYPLL YRDGEQGEPR MGSKSPGNTS 2220 QPPAFFSKLT ESNSAMVKSK KQEINKKLNT HNRNEPEYNI GQPGTEIFNM PAITGAGLMT 2280 CRSQAVQEHA STNMGLEAII RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT 2340 ADGRSDHPLT SPGGGGKAKV SGRPSSRKAK SPAPGLAPGD RPPSVSSVHS EGDCNRRTPL 2400 TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH HAWDEEPKPL 2460 LCSQYETLSD SE 2472 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NCOR2 | A0A452E1G4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NCOR2 | 9612 | Q9Y618 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ncor2 | 20602 | Q9WU42 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NCOR2 | H2RC84 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Ncor2 | 360801 | D3ZXN9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ncor2 | F1R8Z8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000785 | chromatin |
| GO:0000118 | histone deacetylase complex |
| GO:0016604 | nuclear body |
| GO:0000790 | nuclear chromatin |
| GO:0016363 | nuclear matrix |
| GO:0005634 | nucleus |
| GO:0017053 | transcriptional repressor complex |
| GO:0003682 | chromatin binding |
| GO:0003677 | DNA binding |
| GO:0035259 | glucocorticoid receptor binding |
| GO:0042826 | histone deacetylase binding |
| GO:0005112 | Notch binding |
| GO:0035257 | nuclear hormone receptor binding |
| GO:0016922 | nuclear receptor binding |
| GO:0047485 | protein N-terminus binding |
| GO:0044877 | protein-containing complex binding |
| GO:0042974 | retinoic acid receptor binding |
| GO:0046965 | retinoid X receptor binding |
| GO:0001012 | RNA polymerase II regulatory region DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0003714 | transcription corepressor activity |
| GO:0021846 | cell proliferation in forebrain |
| GO:0044849 | estrous cycle |
| GO:0030900 | forebrain development |
| GO:0042593 | glucose homeostasis |
| GO:0003007 | heart morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0007595 | lactation |
| GO:0060766 | negative regulation of androgen receptor signaling pathway |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:1903799 | negative regulation of production of miRNAs involved in gene silencing by miRNA |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0090312 | positive regulation of protein deacetylation |
| GO:0010565 | regulation of cellular ketone metabolic process |
| GO:0032355 | response to estradiol |
| GO:0010243 | response to organonitrogen compound |
| GO:0021537 | telencephalon development |
| GO:0060509 | type I pneumocyte differentiation |
| GO:0050872 | white fat cell differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51293 | SANT |