| Tag | Content |
|---|---|
| Uniprot ID | A0A452E1W7 |
| Entrez ID | 102186373 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018042481.1 |
| Ensembl protein ID | ENSCHIP00000005990 |
| Ensembl nucleotide ID | ENSCHIG00000009920 |
| Gene name | CXXC-type domain-containing protein |
| Gene symbol | TET1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSRSRHARHS KLVRREDLNK KKNNQLKKGS KPANKNVATV KTVSPGKLKQ FVQERDVKKK 60 TEPKLTVPVR SLLTRAGAAR MNLDRTEVLF QNPESLTCNG FTMALRSTSL SRRLSQPPVV 120 IARPKKVPPP KNLGKQHECD YKVLTDMGVK HSENDSVPMQ DPPVPPDIEK LIGIKNASFI 180 KDKSQETTQS WSQGVEDSKI ICSTPSDPAA EILSGSLEGT YGGEGLFSRE TLNNISDSPR 240 MFAQDTVCVP LLQRAALKVT SEGNPSIQLE DLGSRVESLK LSDSYLDPIK SEHGCCPTSS 300 FNKVVPALDL RNCLSIGGSI YPTSLIKLFL AGSEQETLGA KPDHQEVLKA TPDQQEVPDT 360 TPVLGQAVSA VPHQWEVPGA NPVHGEPLGE TLDPPEIPGA IPVQGEIFGA ILNQQVLGMG 420 SGTASDPPIF LPAPHNPVAT CNALPAWPEP QGTVSSGLEV PDTMQILPSG SGHTPQPSSN 480 SEIILVPPVI PMNNIENEKK VHISFLPAHT QGFTLAPERG LQPAPQGIAQ LSLVSPSTLE 540 GGSSQVSATS MVDINTTVVS RPVPLASTSS PSYTTLLPTL EKKKRKRCGV CEPCQQKTNC 600 GECTYCKNRK NSHQICKKRK CEELKKKPSV IVSLEVVKEN KRPQREKKPK VLKADFDNKL 660 VNGPKSESME YSSCAHEEEQ RLELNSCPLE NVTKNEESMT GIEVENWTQN KKSHLTDHVK 720 GEFSTIKTEV ENFKNSEDDR KKILLTDLLE PQKLFAQTVR NGIKNVHYLP TETNLSFKKI 780 NIEELGKAFE SNPYKFLKDT ANHNNVMSTI ATSGSCDHLK GKSNVLVIQK PGFNCKSFPD 840 PVNCNSNSHT SIHNESDQPK SLEIIANREL KEGSTLQPSL LSLMKDRRLT LEQVVAIEAL 900 TQLSEAPSEN SSPSKSEKDE ETEQRTASLL NSCKAILYSV RKDLQDPNLK GEPQSLHHCP 960 SLEKQSSCNA VVFNGQNIIS KSHNSSPSDQ ASTKAQESSA VTNSISLVIP NSNSSKTDTN 1020 KNIAQGRITL DSSRSLQQLT TITSKSEYCN QSLDNSIKLD SKDDSSCQDS VHSKIEEDVA 1080 AQLTQLASMI KFNYVKPEDK KVESTPISLV AYNVQQKYNQ EMGTPPQKPP SNVQNNQGSS 1140 VTKQKNTIQK KTKSTPSRDR RKKKHMVISC QENDQKKQEQ LSYEYSKLHD IWIASKFQRF 1200 GQFGPHDFPI LLGKIPPLTK VWKPLTQTSS ALEHKKLFPP LAQIKFERYY PELAQEKMKV 1260 EPLDSIPIIQ LKTESNGQAF TENAYTQVQP TVNVNQKAHP LLQPASPTNQ CANVLDGSDQ 1320 RQFQEDVKDQ LMHQRLPTSP GISHETPLPD PAQILRNLNV VCSGGITVVS TKNEEDVCSS 1380 SVGTSEFPPI NSAQKTFNDY AMNFFTNPTK TLVSTTKDSE LPTCNCLDRV IQKDKGPYYT 1440 HLGAGPSVAA VREIMENRYG QKGNAIRIEI VVYTGKEGKS SNGCPVAKWV LRRSSDEEKV 1500 LCLVRQRTGH HCPTAVMVVL IMVWDGIPLP MADKLYSQLT ESLKSYNGHP TDRRCTLNEN 1560 RTCTCQGIDP ETCGASFSFG CSWSMYFNGC KFGRSPSPRR FRIDPSSPLH HYYERITKGR 1620 NPERRYMKPE PICPEHEAME KNLEDNLQSL ATELAPIYKQ YAPAAYQNQV ALEHIARECR 1680 LGKKEGRPFS GVTACLDFCA HPHRDIHNMN NGSTVVCTLT REDNRSFGVI PQDEQLHVLP 1740 LYKLSDTDEF GSREGMEAKI KSGAIMVLAP RQKKRMRFTQ PIPRSGKKRA AMMTEVLAHK 1800 IRAVEKKFIP RIKRKNNSMT NNSKASSLPL LGNKTETVQP EIKSETEPHL IFKGSDNTKS 1860 YSPAPFIPHP VKEENLAPAF SWSSKTALVT TAPFKNDASL SYGFSERGSN PHCIMPSARH 1920 SGANVAAGEC AEIAQPGEMV PLPTLSTPMT NSLGYSEPPV GPSEQLTSNQ PNQQPPFITS 1980 PHELASSLVE EDEQPSEADE PPSDDPLSDD PLSPAEEKLP HIVEYWSDSE HIFLDANVGG 2040 VAIAPSHGSV LIECARRELH ATTPVDHPNR NHPTRLSLVF YQHKNLNKPQ HGFELNKIKF 2100 EAKEAKNKKT KASEQKDQAA NEGIELSTEV NEFSQIPSHK ALTLTHDNVV TVSPYALTHV 2160 AGPYNHWV 2168 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TET1 | 102186373 | A0A452E1W7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TET1 | 80312 | Q8NFU7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tet1 | Q3URK3 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | TET1 | 450497 | H2Q1Z7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TET1 | F1SUI3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tet1 | F1LUQ3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tet1 | 101883702 | F1R3C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005506 | iron ion binding |
| GO:0008327 | methyl-CpG binding |
| GO:0070579 | methylcytosine dioxygenase activity |
| GO:0008270 | zinc ion binding |
| GO:0006211 | 5-methylcytosine catabolic process |
| GO:0080111 | DNA demethylation |
| GO:0090310 | negative regulation of methylation-dependent chromatin silencing |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0031062 | positive regulation of histone methylation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51058 | ZF_CXXC |