| Tag | Content |
|---|---|
| Uniprot ID | F1R3C6 |
| Entrez ID | 101883702 |
| Genbank protein ID | AHE93329.1 |
| Genbank nucleotide ID | XM_005156709.3 |
| Ensembl protein ID | ENSDARP00000104252 |
| Ensembl nucleotide ID | ENSDARG00000075230 |
| Gene name | Methylcytosine dioxygenase TET |
| Gene symbol | tet1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. |
| Sequence | MSTLILLQTG SITLKVQFLR RPQYCFSCRL SQTPPPSPSL TSAMPRTAKA PKKSTRASTK 60 RNVKRVKASM TRRQTINSLK ASGEIKKGID KKQAAKRAQR TVVSKPNKKT VEDVLPVKIS 120 RHTTSSLNQN GLLLECNGKG KSPRKSVSCP SIQRDVQKKG AQEIREQETE TKRSEVNDPN 180 GDAEQQKGAE IPTGEGQSVN ISSKESGEEH RETVVNDTLV AEKKKVKVNT ETVQSESYSA 240 VVEQPNTVFV DQQDPLKHNP VNNVDFAYNN NTSGPPTPSP SDQVEAIQPT LPPVDLQDIS 300 LQTTRGNSTE EGETAESSLP NQVCHSSNDS PALENIADAN QIEETELRST ADVDTKDESI 360 DAEMLMKKEG ALSLLSLSAA IYNTTLCEMG HGPQATALLS SSTESTQSSF DSESELVLEH 420 RTSGKSIPQV EDIQLRLLQD QQRREQNKRG HCGVCAPCQC KVNCGECRSC LNQKTDHQIC 480 RLRRCIKLRK KTLIICTGKV ESEANSVNGT SSEQMEETCA APEEEAHYIP VTHNVPPDII 540 TPLQHGLLPE PHGKDPGTTD VLLPHSFSST SHNGAEHIKS NAQRYVDPTE TPANFHSSTI 600 NNRHAPEVVQ EQMVPLKKIK LEEQQLEIDD QHSKHLETNG CYEDALSTLA AVVCFSSTDR 660 KSLEEKLFGS QTSDVCLKTE PKEEPYQCQL NQEEPPQNDY IALSLPTVQS LVQHRNISVD 720 QAIAIEALTQ LAAIPQTVPF KTENQIQDAQ QETSTYSAPS NHIPIREAKP ATDVVSNKVS 780 VISSSLHQTS VIRSSLNTPT NFTQSQRCAP PPRKLSLKDL LMASSECEKL SYTTENRRNG 840 QALCKSDRLE GTFKMYRHGE ATPIYRKKDE EEVAAQLVQL AFMIESRQAQ VSENSPPNGM 900 ATQSLKYNQN YLGQHLKKQR KPKMTPSNPR MSKKKVAEID DNHCRILLAK KTPNKKTPLK 960 ATIQKAISQH KMRFQHKRNP FLPQAQIDLK KYIAEAQHEN RQLLYYNTKK EHLETFIGSG 1020 RQNGFHVKYE HGGHSLPPQN GHFYNHTNDH LGASQCPRHE CEQKVSQVSK TYDVLNPGAK 1080 QQLLQTMANE PFKDLPQIPE MYHKANGFNG HQHLHTNQNG FYKVEKSGGV TVLSASSVHS 1140 ENGDMVYAGE QTPTKHTINS FLESPMRFLD TPTRNLINTP SKQSMEIPSC DCVEHIIEKE 1200 EGPYYTHLGS GPNVAAVREM METRYGEKGN AVRVEVVVYT GKEGRSSQGC PIAKWIIRRG 1260 SEQEKLLCLV RQRAGHCCQN AVIVILILAW EGIPRSVADR LYQELTQTLC KYGSPTSRRC 1320 ALNEDRTCAC QGLDPETCGA SFSFGCSWSM YFNGCKFARS KTPRKFRLQG DSPKEEGRLE 1380 KNLQNLASDL APVYKRLAPK AFHNQVEQEQ RGQDCRLGCR EGRPFSGVTA CVDFCAHAHK 1440 DTHNMTNGST VVCTLTKEDN RAVRNIPEDE QLHVLPLYKI SDTDEFGKVE GQWAKIKTGA 1500 LQVLSAFPRE VRLLAEPVKS AHKRRLEAKR AHVEKLNSLG SKQVTPVKMK NESPKGFKQT 1560 STENSSFSEK NSPNLSSTMR VPDIGGQYSP LHSGGSYNQS NSCRTPPVGS SFGTSTLPKF 1620 PHDPSGGTTH FNGSPPFRHG TIKQEPFRND PVRTNPKFKS EPEEMRCFQG GAAPTPLSPP 1680 MAEGLHSRLN ITAQPVTPEV AKAEEVWSDS EHNFLDKNIG GVAVAPSHGS ILIECARREL 1740 HATTPILRPD RTHPTRISLV FYQHKSLNAP GHGLQQWEAK RAEKAREKEQ AERLGLNNQS 1800 EPVDSDTDSE NETCLDERHK FQVPTRQSLT VSRDSLVMSA PYALTHVTGP YNRWT 1855 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TET1 | 102186373 | A0A452E1W7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TET1 | 80312 | Q8NFU7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tet1 | Q3URK3 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | TET1 | 450497 | H2Q1Z7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TET1 | F1SUI3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tet1 | F1LUQ3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tet1 | 101883702 | F1R3C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0070579 | methylcytosine dioxygenase activity |
| GO:0008270 | zinc ion binding |
| GO:0006211 | 5-methylcytosine catabolic process |
| GO:0071222 | cellular response to lipopolysaccharide |
| GO:0080111 | DNA demethylation |
| GO:0070989 | oxidative demethylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0032656 | regulation of interleukin-13 production |
| GO:0001666 | response to hypoxia |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51058 | ZF_CXXC |
| Pfam ID | Pfam Term |
|---|---|
| PF12851 | Tet_JBP |