| Tag | Content |
|---|---|
| Uniprot ID | F1LUQ3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000000302 |
| Ensembl nucleotide ID | ENSRNOG00000000277 |
| Gene name | Tet methylcytosine dioxygenase 1 |
| Gene symbol | Tet1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSRSRPTKPS KSVKTKLQKK SSQMKKKISK QAVKHGASGK ALTPGKLKQL IRRRDGKKET 60 EVKTPTLPQS LLTRAGAARL NQDRNQVLFQ NPESLTCNGF TMALRRTSLS WRLSQRPVVT 120 PKPKKVPPSK KQCVHNVQDD PGVKHSGNDS GPSQDAVMSP DTENLTGEQN MCLVEGESQE 180 ITQSCSQTVE DSQSCISEYG NLEAGISWSL EGTHSEGLLS HQTSNNVSNS HPGCAPSPQR 240 STSEVTSEKN ASDQFVDLCS PVESPKLSDP SQNPMGSEHN CFPDSSFRIV PELDLKTCMS 300 LDESVYPTAL IKFILAGSQP DVLDTKSEEE TLKTTPEKVG SHPNQVVDAT SILGQAFSTL 360 PHQWGFPGAN LVHSETLAKG SVSPEDLGAI TMLNQPETLG MDMDAPPDLP IFLPMPPNTV 420 ATYSCLLSGP EPHTSASCGL EVQGATPILT LDSGHTPQPP QNSELSSVPL VIAANSTQAE 480 KQFGANLFPA NIQGFTIAPE NELQHAPLDL TQGSHAAPSK LEGGISHVSM TSSADDVKAT 540 MMSMPVTRAS TSSLPCKSMP PTVERRKRKA CGVCEPCQQK ANCGECTYCK NRKNSHQICK 600 KRKCEVLKKK PEATSRVQVT KENKRPQREK KPKVLKTDFN NKPVNGPKSE SMDYSRRGHG 660 EEEQRLGLFT HPLENVRKNA GGMTGIEVEK WTPNKKSHLA AGQVKGSRGA NLAGVENSQP 720 SEDDKQQTNP SPTFAQTVRN GMKNVHCLPT DTDLPLNKLS HEEFSKVLGN NSSKLLTDPS 780 DCKDAMSDTT SREGCDHLKG PRNIVLFQKP GLNCRSGAES TIFNNHPDTH STGSQHQPPE 840 KVPNKEPKDG SPVQPSLLSL MKDRRLTLEQ VVAIEALTQL SEAPSENSSP SKTEKDEETD 900 QRTASLLNSC KDVLHSVRKD FQDPNVQGKS LHHDTVVFNG QNRAFKSPDS FATNQALIKS 960 HEYSRSPTAG KSIASGKAPL DSSKNSCPLP EESQNLENFS QVLICDQNLN SHDPSCQDAP 1020 YSQIEEDVAA QLTQLASTIN HINPEFRNAE STPESLVAKN TQQKHSQEKR MVQQKPPSSI 1080 QNKPIVPSTK PKKTQKKARP TPYTSKRKKK APAHSSQESD QKKQERLAIE YSKMHDIWIS 1140 SQFQRFGQSG PRSLPVLLRN IPIFDQILKP VTQSKTSSHP NKLFPPINQI KFTRNPELAK 1200 ETVKVEPSDS LPTCQFKMES SGQAFSEPAD NSQGQPMVNV DQKAHPLPQS PPSNQCAIYG 1260 CAAQPXHLAL ERTVHQIHPP TWCISPDPLL PDPASALRKG NVLSSNGITV VTTKHEEAQT 1320 SSNGPSDPTT DSAQADFNGN VMDFLSMPAK KLIAELKEQE AATCQCDGGP QKDKGPYYTH 1380 LGAGPSVAAV RELMETRYGQ KGKAIRIEKI VFTGKEGKSS QGCPVAKWVI RRSGPEEKVI 1440 CLVRERVDHY CSTAVIVVLI LLWEGIPRLM ADRLYKELTE NLRSYSGHPT DRRCTLNKKR 1500 TCTCQGTNPK TCGASFSFGC SWSMYFNGCK FGRSANPRKF RLAPNYPLHD YYKRITGRCS 1560 EGSDVKTGWI IPERKTLISR EEKQLEENLQ DLATVLAPVY KQMAPVAYQN QVEYEDIAGD 1620 CRLGNEEGRP FSGVTCCMDF CAHSHKDIHN MNNGSTVVCT LIREDGRDRS VPGDEQLHVL 1680 PLYRLADTDE FGSVEGMKAK IQSGAIQVNG PTRKRRLCFS EPVPRCGKRA KMKEKDKKSG 1740 SHNTKIYSSA SSTPHPVKDE STDFCPLQAS STETSTCMYN KTASGGFPET SSILHCTMPS 1800 GAHSGANAAP GECTGIVQTA AEVAALPHQS LPIADSPLHA EPLTSPPDHL TSNQSNQQLP 1860 FLSSPQKLAS CQVEDERHSE TDEPPQPEDG NIPQLDEFWS DSEEIYNDPA FGGVAIAPIH 1920 GSVLIECARK ELHATTSLSS PKREVPFRVS LVFYQHKNLN KPNHGFDINR IKCKCKKVTK 1980 KPPADREDPD LSPETNLSYQ IPSRVASTLT SDNVVTVSPY ALTHVAGPYN RWV 2033 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TET1 | 102186373 | A0A452E1W7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TET1 | 80312 | Q8NFU7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tet1 | Q3URK3 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | TET1 | 450497 | H2Q1Z7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TET1 | F1SUI3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tet1 | F1LUQ3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tet1 | 101883702 | F1R3C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0005506 | iron ion binding |
| GO:0008327 | methyl-CpG binding |
| GO:0070579 | methylcytosine dioxygenase activity |
| GO:0008270 | zinc ion binding |
| GO:0006211 | 5-methylcytosine catabolic process |
| GO:0080111 | DNA demethylation |
| GO:0001826 | inner cell mass cell differentiation |
| GO:0090310 | negative regulation of methylation-dependent chromatin silencing |
| GO:0070989 | oxidative demethylation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0031062 | positive regulation of histone methylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006493 | protein O-linked glycosylation |
| GO:0044030 | regulation of DNA methylation |
| GO:2000653 | regulation of genetic imprinting |
| GO:0019827 | stem cell population maintenance |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51058 | ZF_CXXC |