| Tag | Content |
|---|---|
| Uniprot ID | H2Q1Z7 |
| Entrez ID | 450497 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016918438.1 |
| Ensembl protein ID | ENSPTRP00000004424 |
| Ensembl nucleotide ID | ENSPTRG00000002558 |
| Gene name | Tet methylcytosine dioxygenase 1 |
| Gene symbol | TET1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSRSRHARPS RLVRKEDVNK KKKNSQLRKT TKGANKNVAS VKTLSPGKLK QLIQERDVKK 60 KTEPKPPMPV RSLLTRAGAA RMNLDRTEVL FQNPESLTCN GFTMALRSTS LSRRLSQPPL 120 VVAKSKKVPL SKGSEKQHDC DYKILPDLGV KHSENDSVPM QDTQVLPDIE TLIGVQNPSL 180 LKGKSQETTQ FWSQRVEDSK INIPTHSGPA AEILPGPLEG TRCGEGLFSE ETLNDTSGSP 240 KMFAQDTVCA PFPQRATPKV TSQGNPSIQL EELGSRVESL KLSDSYLDPI KSEHDCYPTS 300 SLNKVIPDLN LRNCLALGGS TSPTSVIKFL LAGSKQATLG AKPDHQEAFE ATANQQEVSD 360 TTSFLGQAFG AIPHQWELPG ADPVHGEALG ETPDLPEIPG AIPVQGEVFG TILDQQETLG 420 MSGSVVPDLP VFLPVPPNPI ATFNAPSKWP EPQSTVSYGL AVQGAIQILP LGSGHTPQSS 480 SNSEKNSLPP VMAISNVENE KQVHISFLPA NTQGFPLAPE RGLFHASLGV AQLSQAGPSK 540 SDRGSSQVSV TSTVHVVNTT VVTMPVPMVS TSSSSYTTLL PTLEKKKRKR CGVCEPCQQK 600 TNCGECTYCK NRKNSHQICK KRKCEELKKK PSVVVPLEVI KENKRPQREK KPKVLKADFE 660 NKPVNGPKSE SMDYSRCGHG EEQKLELNPH TVENVTKNED SMTGIEVEKW TQNKKSQLTD 720 HVKGDFSANV PEAEKSKNSE VDKKRTKSPK LFVQTVRNGI KHVHCLPAET NVSFKKFNIE 780 EFGKTLENNS YKFLKDTANH NNAMSSVATD MSCDHLKGRS NVLVFQQPGF NCSSIPHSSH 840 SIINHHASIH NEGDQPKTPD NIPSKEPKDG SPVQPSLLSL MKDRRLTLEQ VVAIEALTQL 900 SEAPSENSSP SKSEKDEESE QRTASLLNSC KAILYTVRKD LQDPNLQGEP PKLNHCPSLE 960 KQSSCNTVVF NGQTTTLSNS HINSATNQAS TKSHEYSKVT NSLSLFIPKS NSSKIDTNKS 1020 IAQGIITLDN CSNDLHQLPP RNNEVEYCNQ LLDSSKKLDS DDLSCQDATH TQIEEDVATQ 1080 LTQLASIIKI NYIKPEDKKV ESTPTSLVTC NVQQKYNQEK GTIQQKPPSS VHNNHGSSLT 1140 KQKNPTQKKT KSTPSRDRRK KKPTVVSYQE NDRQKWEKLS YMYGTICDIW IASKFQNFGQ 1200 FCPHDFPTVF GKISSSTKIW KPLAQTRSIM QPKTVFPPLT QIKLQRYPES AEEKVKVEPL 1260 DSLSLFHLKT ESNGKAFTDK AYNSQVQLTV NANQKAHPLT QPSSPPNQCA NVMAGDDQIR 1320 FQQVVKEQLM HQRLPTLPGI SHETPLPESA LTLRNVNVVC SGGITVVSTK SEEEVCSSSF 1380 GTSEFSTVDS AQKNFNDYAM NFFTNPTKNL VSITKDSELP TCSCLDRVIQ KDKGPYYTHL 1440 GAGPSVAAVR EIMENRYGQK GNAIRIEIVV YTGKEGKSSH GCPIAKWVLR RSSDEEKVLC 1500 LVRQRTGHHC PTAVMVVLIM VWDGIPLPMA DRLYTELTEN LKSYNGHPTD RRCTLNENRT 1560 CTCQGIDPET CGASFSFGCS WSMYFNGCKF GRSPSPRRFR IDPSSPLHEK NLEDNLQSLA 1620 TRLAPIYKQY APVAYQNQVE YENVARECRL GSKEGRPFSG VTACLDFCAH PHRDIHNMNN 1680 GSTVVCTLTR EDNRSLGVIP QDEQLHVLPL YKLSDTDEFG SKEGMEAKIK SGAIEVLAPC 1740 RKKRTCFTQP VPRSGKKRAA MMTEVLAHKI RAVEKKPIPR IKRKNNSTTT NNSKASSLPT 1800 LGSKTETVQP EVKSETEPHF ILKSSDNTKT YSLMPSAPHP VKEASPGFSW SPKTASAPPA 1860 PLKNDATASC GFSERSSTPH CTMPSGRLSG ANAAAADGPG ISQLGEVAPL PTLSAPVMEP 1920 LINSEPSTGV TEPLTPHQPN HQPSFLTSPQ DLASSPMEED EQHSEADEPP SDEPLSDDPL 1980 SPAEEKLPHI DEYWSDSEHI FLDANIGGVA IAPAHGSVLI ECARRELHAT TPVEHPNRNH 2040 PTRLSLVFYQ HKNLNKPQHG FELNKIKFEA KEAKNKKMKA SEQKDQAANE GPEQSSEVNE 2100 LNQIPSHKAL TLTHDNVVTV SPYALTHVAG PYNHWV 2136 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TET1 | 102186373 | A0A452E1W7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TET1 | 80312 | Q8NFU7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tet1 | Q3URK3 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | TET1 | 450497 | H2Q1Z7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TET1 | F1SUI3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tet1 | F1LUQ3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tet1 | 101883702 | F1R3C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005506 | iron ion binding |
| GO:0008327 | methyl-CpG binding |
| GO:0070579 | methylcytosine dioxygenase activity |
| GO:0008270 | zinc ion binding |
| GO:0006211 | 5-methylcytosine catabolic process |
| GO:0080111 | DNA demethylation |
| GO:0090310 | negative regulation of methylation-dependent chromatin silencing |
| GO:0070989 | oxidative demethylation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0031062 | positive regulation of histone methylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51058 | ZF_CXXC |