| Tag | Content |
|---|---|
| Uniprot ID | F1SUI3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000010918 |
| Ensembl nucleotide ID | ENSSSCG00000010241 |
| Gene name | CXXC-type domain-containing protein |
| Gene symbol | TET1 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSRSRHARPS KLVRREDLNK KKNSQLKKGS KPANKNVASV KTVNPGKLKQ LIQERDVKKK 60 TELKPPLPVR SLLTRAGAAR MNLDRTEVLF QNPESLTCNG FTMALRSTSL SRRLSQPPVV 120 IAKPKKVPPP KNLGKQHECD YKVLTDMGVK HSENDSKQVP KQDPPIPPDA ENLIGKQNTS 180 LIKDEGQETT QSWPQSVEES EVNHSTHSGP VAEILSESLE GTCGGEGLFS KETLNDNSDS 240 PGTFAQDTLC VPLLQRAALK VTSEGSPSIQ LEDLGSRVES LKLSDSYLDP IKSEHDCCPT 300 SSFNKVVPEL DLRNCLSIGG SIYPTSLIKL LLAGSEQETL CAKPDYQEVL KATPDQQEIP 360 DTTPVLGQVF SAIPHPWEVP GANPVHGEPL GETPNPPEIP GAIPVQGEVF GAILNQQVLG 420 MGGGTASDPP IFLPAPPNQI ATYYPLPEWP EPLSTVSSGL QVQGAMQILP LGSDHTPQPS 480 SNSEISSVPP VMAINSIENE KQVHISFLPA NTQGFTLAPE SGHYHAPQGI AQLSQVSPSR 540 LEGGSSQIST TSTLDANTTV VSRPVSFAST SSSPSYTTLL PTLEKKKRKR CGVCEPCQQK 600 TNCGECTYCK NRKNSHQICK KRKCEELKKK PSIIVPLEAD FDNKPVNGPK SESMEYSSCG 660 HEEEQRLELS VFPFEHVTKN EESMTGIEVE KWTQNKKSNL SDHVKGEFNA IITEAENRKN 720 SEDDRKKVLL TDLLEPQKLF AQTVRNGIKN VHYLPTETNL SFKKINIEEL GKAFENNPYK 780 FLKDTASHNN AMSSIATSAS CDHLKGRNNI LVFQKPGFNC KSFPDPANCN LNSRTSVHNE 840 SDQPKSLENI TNREPKEGAT LQPSLLSLMK DRRLTLEQVV AIEALTQLSE APSENSSPSK 900 SEKDEETEQR TASLLNSCKA ILYSVRKDLQ DPNLQGEPQS LHHCPSLEKQ NSCNTIVFNG 960 QNNISKSHSS SPSDQASTKA QEYSTVTNSI SLFIPNSNSS KTDTNKNVAQ GKVTLNSSKN 1020 LHQLTVTNKL ENCNQSLDSS NKLDSKDNPS CQDTVHSKIE EDVATQLTQL ASIIKFNYTK 1080 AEDKKVESTP NLTAYNVQQN YCQKTIQQKP PSSVQNNHGS SVTKQKNPTQ KKTKSTPSRD 1140 RRKKKPAVIS CQENDQKKQE QLSYEYSKLH DIWIASKFQR FGQFGPHNFP ILLGKIPPLT 1200 KVWKPLTQKR SALEHKTLFP PLNQIKVDRY YPELAQDKMK VEPLDSFPII QLKTESSGQA 1260 FTENAYPQVP PTVNVNQKVH PLLQPSSPTN QCANVMAGND QTQFQQDVKD QHMHQRLPTL 1320 PGISHETPLP DPAQILRNLN VVCSGGITVV STKSEEDVCL SSIGASEFSP IDNAQKSFND 1380 YAMNFFTNPT KTLVSTTKDS ELPTCNCLDR VIQKDKGPYY THLGAGPSVA AVREIMENRY 1440 GQKGNAIRIE IVVYTGKEGK SSNGCPVAKW VLRRSSDEEK VLCLVRQRAG HHCPTAVMVV 1500 LIMVWDGIPL PLADRLYSEL TESLKSYNGH PTDRRCTLNE NRTCTCQGLD PETCGASFSF 1560 GCSWSMYFNG CKFGRSPSPR RFRIDPSSPL HHYYERITKG RNPERRYMKP EPICPEHKAM 1620 EKNIEDNLQT LATELAPIYK QYAPVAYENQ VAFEHVAREC RLGKKEGRPF SGVTACLDFC 1680 AHPHRDIHNM NNGSTVVCTL TREDNRSFGV IPQDEQLHVL PLYKLSDTDE FGSREGIEAK 1740 IKSGAIKVLT PCSRRRTRFT QPIPRSGKKR AAMMTEVLAH KIRAVEKKFI PRIKRKNNSM 1800 MNNSKASSLP LLGNKIETMQ PEIKSETEPH LIFKGSENTK TYSPTPSIPH PVKEANLAPG 1860 FSWSPKSASV TTPPFKNDAT VSYGFSERSS NPHCTTPSAG HGGANAAAGE GTGIAQPGER 1920 FPLPTLSTPG TDSLGYPEPP TGPCEHLPSH QPNQQSPFVT FPHDPASSLV EEDEQHSEAD 1980 EPLSDDPLSD DPLSPVEEKL PRIEEYWSDS EHIFLDANIG GVAIAPAHGS VLIECARREL 2040 HATTPVEHPN RNHPTRLSLV FYQHKNLNKP QHGFELNKIK FEAKEAKNKK IKASEQKDQA 2100 ANEGPELSPE INEFSQIPSH KALTLTHDNV VTVSPYALTH VAGPYNHWV 2149 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TET1 | 102186373 | A0A452E1W7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TET1 | 80312 | Q8NFU7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tet1 | Q3URK3 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | TET1 | 450497 | H2Q1Z7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TET1 | F1SUI3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tet1 | F1LUQ3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tet1 | 101883702 | F1R3C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005506 | iron ion binding |
| GO:0008327 | methyl-CpG binding |
| GO:0070579 | methylcytosine dioxygenase activity |
| GO:0008270 | zinc ion binding |
| GO:0006211 | 5-methylcytosine catabolic process |
| GO:0080111 | DNA demethylation |
| GO:0090310 | negative regulation of methylation-dependent chromatin silencing |
| GO:0070989 | oxidative demethylation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0031062 | positive regulation of histone methylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51058 | ZF_CXXC |