| Tag | Content |
|---|---|
| Uniprot ID | A0A452EBD2 |
| Entrez ID | 102173941 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005686101.3 |
| Ensembl protein ID | ENSCHIP00000009460 |
| Ensembl nucleotide ID | ENSCHIG00000012309 |
| Gene name | Homeobox domain-containing protein |
| Gene symbol | SIX4 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSSSSPTGQI ASAADIKQEN GMESASEGQE APREVAGGAA AAAGLSPPAP APFPLEPGDA 60 AAAAARVSGE EGAVAAAAGA AVDQVQLHSE LLGRHHHAAA AAAAQTPLAF SPDHVACVCE 120 ALQQGGNLDR LARFLWSLPQ SDLLRGNESL LKARALVAFH QGIYPELYSI LESHSFESAN 180 HPLLQQLWYK ARYTEAERAR GRPLGAVDKY RLRRKFPLPR TIWDGEETVY CFKEKSRNAL 240 KELYKQNRYP SPAEKRHLAK ITGLSLTQVS NWFKNRRQRD RNPSETQSKS ESDGNPSTED 300 ESSKGHEDLS PHQLSSSSDG VTNLSLSSHL EPVYMQQIGN AKISLSSSGV LLNGSLVPAS 360 TSPVFLNGNS FIQGPNGVIL NGLSVGNTQT VSLNPPKMAS NIMSNGISMT DILGSTSQDV 420 KEFKVLQSSS ANSAASTSYS PSAPVSFPGL IPSAEVKREG IQTVASQDGG SVVTFTTPVQ 480 INQYGIVQIP NSGANSQFLN GSIGFSPLQL PPVSVAASQG NISVNSSTSD GSTFTSESAT 540 VQQGKVFLSS LAPSAVVYTV PNSGQTIGSV KQEGVERSLV FSQLMPVNQN AQVNANLSSE 600 SISGSGLHPL SSSLVNVSPA HNFSLTSPTL LNPTELNPDI ADSQPMSAPV ASKSTVTSVN 660 NTNYATLQNC SLISGQDLLS VPLTQAALGE IVPTGEDQVG HPSPTVHQDF VREHHLVMQS 720 VANIKENFLT NSESKTTSNL MMLDSKSKYV LDGMVETVCE DLETDKKELA KLQTVQLDED 780 MQDL 784 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX4 | 490720 | F6XRS2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 102173941 | A0A452EBD2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 51804 | Q9UIU6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six4 | 20474 | Q61321 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX4 | 452953 | K7A7J5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | F1SRW3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Six4 | 299138 | D3ZAJ7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0061197 | fungiform papilla morphogenesis |
| GO:0048699 | generation of neurons |
| GO:0042472 | inner ear morphogenesis |
| GO:0008584 | male gonad development |
| GO:0030238 | male sex determination |
| GO:0072075 | metanephric mesenchyme development |
| GO:0051451 | myoblast migration |
| GO:0061055 | myotome development |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:1902725 | negative regulation of satellite cell differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030910 | olfactory placode formation |
| GO:0060037 | pharyngeal system development |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0072107 | positive regulation of ureteric bud formation |
| GO:0034504 | protein localization to nucleus |
| GO:0072095 | regulation of branch elongation involved in ureteric bud branching |
| GO:0050678 | regulation of epithelial cell proliferation |
| GO:0032880 | regulation of protein localization |
| GO:0008582 | regulation of synaptic growth at neuromuscular junction |
| GO:0045214 | sarcomere organization |
| GO:0098528 | skeletal muscle fiber differentiation |
| GO:0048538 | thymus development |
| GO:0061551 | trigeminal ganglion development |