| Tag | Content |
|---|---|
| Uniprot ID | F6XRS2 |
| Entrez ID | 490720 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_547842.5 |
| Ensembl protein ID | ENSCAFP00000022969 |
| Ensembl nucleotide ID | ENSCAFG00000015627 |
| Gene name | SIX homeobox 4 |
| Gene symbol | SIX4 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSSSSPTGQI ASAADIKQEN GMESASEGQE APQEVAGGAA AGLSPPAPAP FPLEPGDAAA 60 AAARVSAEEG AAAAANQVQL HSELLGRHHH AAAAAAAAAA AAAAAAQTPL AFSPDHVACV 120 CEALQQGGNL DRLARFLWSL PQSDLLRGNE SLLKARALVA FHQGIYPELY SILESHSFES 180 ANHPLLQQLW YKARYTEAER ARGRPLGAVD KYRLRRKFPL PRTIWDGEET VYCFKEKSRN 240 ALKELYKQNR YPSPAEKRHL AKITGLSLTQ VSNWFKNRRQ RDRNPSETQS KSESDGNPST 300 EDESSKGHED LSPHPLSGSS DSVTNLSLPS HMEPVYMQQI GNAKISLSSS GVLLNGSLVP 360 ASTSPVFLNG NSFIQGPNGV ILNGLNVGNT QAVSLNPPKM ASNIVSNGIS MSDILGSTSQ 420 DVKEFKVLQS SSANSAATTS YSPSAPVSFP GLIPSTEVKR EGIQTVASQD GGSVVTFTTP 480 VQINQYGIVQ IPNSGTNSQF LNGSIGFSPL QLPSVSVAAS QGNLSVNAST SDGSTFTSES 540 TTVQQGKVFL SSLAPSAVVY TVPNSGQTMG SVKQEGLERS LVFSQLMPVN QNAQINANLS 600 SENISGSGLH PLASLVNVSP THNFPLTPPT LLNPTELNPD LADSQPMSAP VASKSTVTSV 660 SSTNYATLQN CSLITGQDLL SVPMTQTSLG EIVPTAEDQV GHPSPAVHQD FVREHRLVLQ 720 SVANIKENFL TNSEGKTTSN LMMLDSKSKY VLEGMVETVC EDLETDKKDL AKLQTVQLDE 780 DMQDL 785 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX4 | 490720 | F6XRS2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 102173941 | A0A452EBD2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 51804 | Q9UIU6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six4 | 20474 | Q61321 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX4 | 452953 | K7A7J5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | F1SRW3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Six4 | 299138 | D3ZAJ7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:0045892 | negative regulation of transcription, DNA-templated |