| Tag | Content |
|---|---|
| Uniprot ID | K7A7J5; A0A2J8PI69; H2R2J7; |
| Entrez ID | 452953 |
| Genbank protein ID | JAA03653.1; JAA36545.1; |
| Genbank nucleotide ID | XM_016926173.1 |
| Ensembl protein ID | ENSPTRP00000044052 |
| Ensembl nucleotide ID | ENSPTRG00000006411 |
| Gene name | SIX homeobox 4 |
| Gene symbol | SIX4 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSSSSPTGQI ASAADIKQEN GMESASEGQE AHREVAGGAA VGLSPPAPAP FPLEPGDAAT 60 AAARVSGEEG AVAAAAAGAA ADQVQLHSEL LGRHHHAAAA AAQTPLAFSP DHVACVCEAL 120 QQGGNLDRLA RFLWSLPQSD LLRGNESLLK ARALVAFHQG IYPELYSILE SHSFESANHP 180 LLQQLWYKAR YTEAERARGR PLGAVDKYRL RRKFPLPRTI WDGEETVYCF KEKSRNALKE 240 LYKQNRYPSP AEKRHLAKIT GLSLTQVSNW FKNRRQRDRN PSETQSKSES DGNPSTEDES 300 SKGHEDLSPH PLSGSSDGIT NLSLSSHMEP VYMQQIGNAK ISLSSSGVLL NGSLVPASTS 360 PVFLNGNSFI QGPSGVILNG LNVGNTQAVA LNPPKMSSNI VSNGISMTDI LGSTSQDVKE 420 FKVLQSSANS AATTSYSPSV PVSFPGLIPS TEVKREGIQT VASQDGGSVV TFTTPVQINQ 480 YGIVQIPNSG ANSQFLNGSI GFSPLQLPPV SVAASQGNIS VSSSTSDGST FTSESTTVQQ 540 GKVFLSSLAP SAVVYTVPNT GQTIGSVKQE GLERSLVFSQ LMPVNQNAQV NANLSSENIS 600 GSGLHPLASS LVNVSPTHNF SLSPSTLLNP TELNRDIADS QPMSAPVASK STVTSVSNTN 660 YATLQNCSLI TGQDLLSVPM TQAALGEIVP TAEDQVGHPS PAVHQDFVQE HRLVLQSVAN 720 MKENFLSNSE SKATSSLMML DSKSKYVLDG MVDTVCEDLE TDKKELAKLQ TVQLDEDMQD 780 L 781 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX4 | 490720 | F6XRS2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 102173941 | A0A452EBD2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 51804 | Q9UIU6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six4 | 20474 | Q61321 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX4 | 452953 | K7A7J5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | F1SRW3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Six4 | 299138 | D3ZAJ7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0061197 | fungiform papilla morphogenesis |
| GO:0048699 | generation of neurons |
| GO:0042472 | inner ear morphogenesis |
| GO:0008584 | male gonad development |
| GO:0030238 | male sex determination |
| GO:0072075 | metanephric mesenchyme development |
| GO:0051451 | myoblast migration |
| GO:0061055 | myotome development |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:1902725 | negative regulation of satellite cell differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030910 | olfactory placode formation |
| GO:0060037 | pharyngeal system development |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0072107 | positive regulation of ureteric bud formation |
| GO:0034504 | protein localization to nucleus |
| GO:0072095 | regulation of branch elongation involved in ureteric bud branching |
| GO:0050678 | regulation of epithelial cell proliferation |
| GO:0032880 | regulation of protein localization |
| GO:0008582 | regulation of synaptic growth at neuromuscular junction |
| GO:0045214 | sarcomere organization |
| GO:0098528 | skeletal muscle fiber differentiation |
| GO:0048538 | thymus development |
| GO:0061551 | trigeminal ganglion development |