| Tag | Content |
|---|---|
| Uniprot ID | D3ZAJ7 |
| Entrez ID | 299138 |
| Genbank protein ID | EDM03608.1 |
| Genbank nucleotide ID | NM_001106739.1 |
| Ensembl protein ID | ENSRNOP00000050667 |
| Ensembl nucleotide ID | ENSRNOG00000007250 |
| Gene name | SIX homeobox 4 |
| Gene symbol | Six4 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MIASAADIKQ ENGMESASEG QEAHREPPLA FSPDHVACVC EALQQGGNLD RLARFLWSLP 60 QSDLLRGNES LLKARALVAF HQGIYPELYS ILESHSFESA NHPLLQQLWY KARYTEAERA 120 RGRPLGAVDK YRLRRKFPLP RTIWDGEETV YCFKEKSRNA LKELYKQNRY PSPAEKRHLA 180 KITGLSLTQV SNWFKNRRQR DRNPSETQSK SESDGNPSTE DESSKGHEDL SPHPLSGASD 240 GVTNLSLSSH MEPVYMQQIG NAKISLSSSG VLLNGSLVPA STSPVFLNGN SFIQGHNGVI 300 LNGLNVGNTQ TVSLNPPKMS SNTVGNGIAM TDILGSTSQD VKEFKVLQSS AVNSAATTSY 360 SPSAPVSFPG LIPCTEVKRE GVQTVASQDG GSVVTFTTPV QINQYGIVQI PNSGANGQFL 420 NGSIGFSPLQ LPPVSVSASQ GHLSVTPSTS DGSTFTSESA TVQHGKLFLS PLTPSAVVYT 480 VPNSGQTVGA VKQEGLERGL VFSQLMPVNH NAQVNANLSS ENLSGSGLHP LTSSLVNVSA 540 AHGFSLTPST LLNPAELNPD LAESQPVSAP VASKCTVTSV SNTNYATLQN CSLIPGPDLL 600 SVPMTQAALG EIVPTAEEQV SHASPAVHQD FVREQRLVLQ SVANLKENFL QNSENKTTNN 660 LMMLDSKSKY VLDGMVEPGC EDLGTDKKEL AKLQTVQLDE DMQDL 705 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SIX4 | 490720 | F6XRS2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 102173941 | A0A452EBD2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | 51804 | Q9UIU6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Six4 | 20474 | Q61321 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SIX4 | 452953 | K7A7J5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SIX4 | F1SRW3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Six4 | 299138 | D3ZAJ7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003677 | DNA binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0061197 | fungiform papilla morphogenesis |
| GO:0048699 | generation of neurons |
| GO:0042472 | inner ear morphogenesis |
| GO:0008584 | male gonad development |
| GO:0030238 | male sex determination |
| GO:0046661 | male sex differentiation |
| GO:0072075 | metanephric mesenchyme development |
| GO:0051451 | myoblast migration |
| GO:0061055 | myotome development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:1902725 | negative regulation of satellite cell differentiation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030910 | olfactory placode formation |
| GO:0060037 | pharyngeal system development |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0072107 | positive regulation of ureteric bud formation |
| GO:0034504 | protein localization to nucleus |
| GO:0072095 | regulation of branch elongation involved in ureteric bud branching |
| GO:0050678 | regulation of epithelial cell proliferation |
| GO:0010468 | regulation of gene expression |
| GO:0032880 | regulation of protein localization |
| GO:0008582 | regulation of synaptic growth at neuromuscular junction |
| GO:0045214 | sarcomere organization |
| GO:0098528 | skeletal muscle fiber differentiation |
| GO:0007519 | skeletal muscle tissue development |
| GO:0048538 | thymus development |
| GO:0043586 | tongue development |
| GO:0061551 | trigeminal ganglion development |