Tag | Content |
---|---|
Uniprot ID | A0A452EGK7 |
Entrez ID | |
Genbank protein ID | |
Genbank nucleotide ID | |
Ensembl protein ID | ENSCHIP00000011113 |
Ensembl nucleotide ID | ENSCHIG00000013353 |
Gene name | Serine/threonine-protein kinase receptor |
Gene symbol | ACVR2A |
Organism | Capra hircus |
NCBI taxa ID | 9925 |
Cleft type | |
Developmental stage | |
Data sources | Homology search |
Reference | |
Functional description | |
Sequence | MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 60 FATWKNISGS IDIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 120 EVTQPTSNPV TPKPPYYNIL LYSLVPLMLV AGIVICAFWV YRHHKMAYPP VLVPTQHAFH 180 IMIEDPGPPP PSPLLGLKPL QLLEVKARGR FGCVWKAQLL NEYVAVKIFP IQDKQSWQNE 240 YEVYSLPGMK HENILQFIGA EKRGTSVDVD LWLITAFHEK GSLSDFLKAN VVSWNELCHI 300 AETMARGLAY LHEDIPGLKD GHKPAISHRD IKSKNVLLKN NLTACIADFG LALKFEAGKS 360 AGDTHGQVGT RRYMAPEVLE GAINFQRDAF LRIDMYAMGL VLWELASRCT AADGPVDEYM 420 LPFEEEIGQH PSLEDMQEVV VHKKKRPVLR DYWQKHAGMA MLCETIEECW DHDAEARLSA 480 GCVGERITQM QRLTNIITTE DIVTVVTMVT NVDFPPKESS L 521 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
---|---|---|---|---|---|---|---|---|
1:1 ortholog | ACVR2A | 281598 | Q28043 | Bos taurus | Prediction | More>> | ||
1:1 ortholog | ACVR2A | 476140 | F1PKQ5 | Canis lupus familiaris | Prediction | More>> | ||
1:1 ortholog | ACVR2A | A0A452EGK7 | Capra hircus | Prediction | More>> | |||
1:1 ortholog | ACVR2A | 100049823 | F7CD19 | Equus caballus | Prediction | More>> | ||
1:1 ortholog | ACVR2A | 92 | P27037 | Homo sapiens | Prediction | More>> | ||
1:1 ortholog | Acvr2a | 11480 | P27038 | CPO | Mus musculus | Publication | More>> | |
1:1 ortholog | ACVR2A | 459646 | K7ALD8 | Pan troglodytes | Prediction | More>> | ||
1:1 ortholog | ACVR2A | F1S0H6 | Sus scrofa | Prediction | More>> | |||
1:1 ortholog | Acvr2a | F1MA24 | Rattus norvegicus | Prediction | More>> |
GO ID | GO Term |
---|---|
GO:0009986 | cell surface |
GO:0005737 | cytoplasm |
GO:0034673 | inhibin-betaglycan-ActRII complex |
GO:0016021 | integral component of membrane |
GO:0043235 | receptor complex |
GO:0048185 | activin binding |
GO:0017002 | activin-activated receptor activity |
GO:0005524 | ATP binding |
GO:0098821 | BMP receptor activity |
GO:0015026 | coreceptor activity |
GO:0019838 | growth factor binding |
GO:0034711 | inhibin binding |
GO:0046872 | metal ion binding |
GO:0030165 | PDZ domain binding |
GO:0043621 | protein self-association |
GO:0009952 | anterior/posterior pattern specification |
GO:0007368 | determination of left/right symmetry |
GO:0048706 | embryonic skeletal system development |
GO:0001702 | gastrulation with mouth forming second |
GO:0007498 | mesoderm development |
GO:0043084 | penile erection |
GO:0032927 | positive regulation of activin receptor signaling pathway |
GO:0030501 | positive regulation of bone mineralization |
GO:0045648 | positive regulation of erythrocyte differentiation |
GO:0045669 | positive regulation of osteoblast differentiation |
GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
GO:0045944 | positive regulation of transcription by RNA polymerase II |
GO:0050999 | regulation of nitric-oxide synthase activity |
GO:0060011 | Sertoli cell proliferation |
GO:0042713 | sperm ejaculation |
GO:0007283 | spermatogenesis |
Keyword ID | Keyword Term |
---|---|
KW-0067 | ATP-binding |
KW-0418 | Kinase |
KW-0460 | Magnesium |
KW-0464 | Manganese |
KW-0472 | Membrane |
KW-0479 | Metal-binding |
KW-0547 | Nucleotide-binding |
KW-0675 | Receptor |
KW-1185 | Reference proteome |
KW-0723 | Serine/threonine-protein kinase |
KW-0732 | Signal |
KW-0808 | Transferase |
KW-0812 | Transmembrane |
KW-1133 | Transmembrane helix |