Gene: Acvr2a

Basic information

Tag Content
Uniprot ID F1MA24
Entrez ID
Genbank protein ID EDM00469.1
Genbank nucleotide ID
Ensembl protein ID ENSRNOP00000007404
Ensembl nucleotide ID ENSRNOG00000005334
Gene name Serine/threonine-protein kinase receptor
Gene symbol Acvr2a
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 60
FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 120
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologACVR2A281598Q28043Bos taurusPredictionMore>>
1:1 orthologACVR2A476140F1PKQ5Canis lupus familiarisPredictionMore>>
1:1 orthologACVR2AA0A452EGK7Capra hircusPredictionMore>>
1:1 orthologACVR2A100049823F7CD19Equus caballusPredictionMore>>
1:1 orthologACVR2A92P27037Homo sapiensPredictionMore>>
1:1 orthologAcvr2a11480P27038CPOMus musculusPublicationMore>>
1:1 orthologACVR2A459646K7ALD8Pan troglodytesPredictionMore>>
1:1 orthologACVR2AF1S0H6Sus scrofaPredictionMore>>
1:1 orthologAcvr2aF1MA24Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0009986 cell surface
GO:0005737 cytoplasm
GO:0034673 inhibin-betaglycan-ActRII complex
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0048185 activin binding
GO:0017002 activin-activated receptor activity
GO:0005524 ATP binding
GO:0098821 BMP receptor activity
GO:0015026 coreceptor activity
GO:0019838 growth factor binding
GO:0034711 inhibin binding
GO:0046872 metal ion binding
GO:0030165 PDZ domain binding
GO:0043621 protein self-association
GO:0009952 anterior/posterior pattern specification
GO:0007368 determination of left/right symmetry
GO:0048706 embryonic skeletal system development
GO:0001702 gastrulation with mouth forming second
GO:0007498 mesoderm development
GO:0043084 penile erection
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0030501 positive regulation of bone mineralization
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050999 regulation of nitric-oxide synthase activity
GO:0060011 Sertoli cell proliferation
GO:0042713 sperm ejaculation
GO:0007283 spermatogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0418 Kinase
KW-0460 Magnesium
KW-0464 Manganese
KW-0472 Membrane
KW-0479 Metal-binding
KW-0547 Nucleotide-binding
KW-0675 Receptor
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0732 Signal
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR000472 Activin_recp
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor

PROSITE

PROSITE ID PROSITE Term
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF01064 Activin_recp
PF00069 Pkinase