| Tag | Content |
|---|---|
| Uniprot ID | F7CD19 |
| Entrez ID | 100049823 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001242549.1 |
| Ensembl protein ID | ENSECAP00000000141 |
| Ensembl nucleotide ID | ENSECAG00000000138 |
| Gene name | Serine/threonine-protein kinase receptor |
| Gene symbol | ACVR2A |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVEPC YGDKDKRRHC 60 FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 120 EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180 PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240 MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300 AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420 QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480 QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACVR2A | 281598 | Q28043 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | 476140 | F1PKQ5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | A0A452EGK7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACVR2A | 100049823 | F7CD19 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | 92 | P27037 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acvr2a | 11480 | P27038 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACVR2A | 459646 | K7ALD8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | F1S0H6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Acvr2a | F1MA24 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0048179 | activin receptor complex |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0048185 | activin binding |
| GO:0017002 | activin-activated receptor activity |
| GO:0005524 | ATP binding |
| GO:0046872 | metal ion binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0032924 | activin receptor signaling pathway |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0006468 | protein phosphorylation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |