| Tag | Content |
|---|---|
| Uniprot ID | Q28043; A5D7L7; |
| Entrez ID | 281598 |
| Genbank protein ID | AAI40606.1; AAA74597.1; AAC48694.1; |
| Genbank nucleotide ID | NM_174227.3 |
| Ensembl protein ID | ENSBTAP00000024108 |
| Ensembl nucleotide ID | ENSBTAG00000018114 |
| Gene name | Activin receptor type-2A |
| Gene symbol | ACVR2A |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. |
| Sequence | MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 60 FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 120 EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180 PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240 MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300 AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420 QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480 QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACVR2A | 281598 | Q28043 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | 476140 | F1PKQ5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | A0A452EGK7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACVR2A | 100049823 | F7CD19 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | 92 | P27037 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acvr2a | 11480 | P27038 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACVR2A | 459646 | K7ALD8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | F1S0H6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Acvr2a | F1MA24 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0048179 | activin receptor complex |
| GO:0009986 | cell surface |
| GO:0005737 | cytoplasm |
| GO:0034673 | inhibin-betaglycan-ActRII complex |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0048185 | activin binding |
| GO:0017002 | activin-activated receptor activity |
| GO:0005524 | ATP binding |
| GO:0098821 | BMP receptor activity |
| GO:0015026 | coreceptor activity |
| GO:0019838 | growth factor binding |
| GO:0034711 | inhibin binding |
| GO:0046872 | metal ion binding |
| GO:0030165 | PDZ domain binding |
| GO:0043621 | protein self-association |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0032924 | activin receptor signaling pathway |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0030509 | BMP signaling pathway |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0007368 | determination of left/right symmetry |
| GO:0048706 | embryonic skeletal system development |
| GO:0001702 | gastrulation with mouth forming second |
| GO:0007498 | mesoderm development |
| GO:0043084 | penile erection |
| GO:0032927 | positive regulation of activin receptor signaling pathway |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0045648 | positive regulation of erythrocyte differentiation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006468 | protein phosphorylation |
| GO:0050999 | regulation of nitric-oxide synthase activity |
| GO:0060011 | Sertoli cell proliferation |
| GO:0042713 | sperm ejaculation |
| GO:0007283 | spermatogenesis |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |