| Tag | Content |
|---|---|
| Uniprot ID | P27038 |
| Entrez ID | 11480 |
| Genbank protein ID | AAA37171.1 |
| Genbank nucleotide ID | NM_007396.4 |
| Ensembl protein ID | ENSMUSP00000067305 |
| Ensembl nucleotide ID | ENSMUSG00000052155 |
| Gene name | Activin receptor type-2A |
| Gene symbol | Acvr2a |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 7885474 |
| Functional description | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). |
| Sequence | MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 60 FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 120 EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180 PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240 MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300 AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420 QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480 QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACVR2A | 281598 | Q28043 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | 476140 | F1PKQ5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | A0A452EGK7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACVR2A | 100049823 | F7CD19 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | 92 | P27037 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acvr2a | 11480 | P27038 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACVR2A | 459646 | K7ALD8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ACVR2A | F1S0H6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Acvr2a | F1MA24 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | ISO |
| GO:0004674 | protein serine/threonine kinase activity | IBA |
| GO:0004674 | protein serine/threonine kinase activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0015026 | coreceptor activity | ISO |
| GO:0017002 | activin-activated receptor activity | IBA |
| GO:0019838 | growth factor binding | IPI |
| GO:0019838 | growth factor binding | IMP |
| GO:0030165 | PDZ domain binding | IPI |
| GO:0034711 | inhibin binding | ISO |
| GO:0034711 | inhibin binding | IPI |
| GO:0043621 | protein self-association | IPI |
| GO:0046872 | metal ion binding | IEA |
| GO:0048185 | activin binding | ISO |
| GO:0048185 | activin binding | IPI |
| GO:0048185 | activin binding | IBA |
| GO:0098821 | BMP receptor activity | IMP |
| GO:0017002 | activin-activated receptor activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001702 | gastrulation with mouth forming second | IGI |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0006468 | protein phosphorylation | IBA |
| GO:0007283 | spermatogenesis | IGI |
| GO:0007368 | determination of left/right symmetry | IGI |
| GO:0007498 | mesoderm development | IMP |
| GO:0008584 | male gonad development | IMP |
| GO:0009952 | anterior/posterior pattern specification | IGI |
| GO:0009966 | regulation of signal transduction | IDA |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | ISO |
| GO:0030501 | positive regulation of bone mineralization | ISO |
| GO:0030509 | BMP signaling pathway | ISO |
| GO:0030509 | BMP signaling pathway | IMP |
| GO:0032924 | activin receptor signaling pathway | ISO |
| GO:0032924 | activin receptor signaling pathway | IBA |
| GO:0032927 | positive regulation of activin receptor signaling pathway | ISO |
| GO:0042713 | sperm ejaculation | IMP |
| GO:0043084 | penile erection | IMP |
| GO:0045648 | positive regulation of erythrocyte differentiation | ISO |
| GO:0045669 | positive regulation of osteoblast differentiation | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0046881 | positive regulation of follicle-stimulating hormone secretion | ISO |
| GO:0048706 | embryonic skeletal system development | IMP |
| GO:0050999 | regulation of nitric-oxide synthase activity | IMP |
| GO:0060011 | Sertoli cell proliferation | IMP |
| GO:0071363 | cellular response to growth factor stimulus | IBA |
| GO:0071773 | cellular response to BMP stimulus | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0005886 | plasma membrane | TAS |
| GO:0009986 | cell surface | IDA |
| GO:0034673 | inhibin-betaglycan-ActRII complex | ISO |
| GO:0043235 | receptor complex | ISO |
| GO:0043235 | receptor complex | IBA |
| GO:0048179 | activin receptor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1502540 | Signaling by Activin | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-201451 | Signaling by BMP | IEA |
| R-MMU-9006936 | Signaling by TGF-beta family members | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |