| Tag | Content |
|---|---|
| Uniprot ID | A0A452EK01 |
| Entrez ID | 102190677 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018049722.1 |
| Ensembl protein ID | ENSCHIP00000012268 |
| Ensembl nucleotide ID | ENSCHIG00000014094 |
| Gene name | Homeobox domain-containing protein |
| Gene symbol | MSX1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAPAADMTSL PLGVKVEDSA FGKPAGGGGG QTPSTTAATA AAMGADEEGA KPKVSPSLLP 60 FSVEALMADH RKPGAKDSVL AASEGAQAAG GSAQPLGARP GSLGAPDAPS SPRPLGHFSV 120 GGLLKLPEDA LVKAESPEKP ERTPWMQNPR FSPPPARRLS PPACTLRKHK TNRKPRTPFT 180 TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM 240 AAKPMLPPAA FGLSFPLGGP AAVAAAAGAS LYGASGPFQR AALPVAPVGL YTAHVGYSMY 300 HLT 303 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSX1 | 102190677 | A0A452EK01 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSX1 | 4487 | P28360 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Msx1 | 17701 | P13297 | CPO,CLP | E11.5, E13.0, E12.5, E14.0, E13.5, E14.5, E15.0, E15.5, E16.0 | Mus musculus | Publication | More>> |
| 1:1 ortholog | MSX1 | 461092 | Q2VL88 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSX1 | F1S5G6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Msx1 | G3V6U7 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | msx1a | B3DG59 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0035326 | cis-regulatory region binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0002039 | p53 binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0090427 | activation of meiosis |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0061312 | BMP signaling pathway involved in heart development |
| GO:0060349 | bone morphogenesis |
| GO:0060536 | cartilage morphogenesis |
| GO:0000902 | cell morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0035880 | embryonic nail plate morphogenesis |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0060325 | face morphogenesis |
| GO:0030900 | forebrain development |
| GO:0001701 | in utero embryonic development |
| GO:0061180 | mammary gland epithelium development |
| GO:0010463 | mesenchymal cell proliferation |
| GO:0030901 | midbrain development |
| GO:0042474 | middle ear morphogenesis |
| GO:0007517 | muscle organ development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030308 | negative regulation of cell growth |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0051154 | negative regulation of striated muscle cell differentiation |
| GO:2000678 | negative regulation of transcription regulatory region DNA binding |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:2001055 | positive regulation of mesenchymal cell apoptotic process |
| GO:0034504 | protein localization to nucleus |
| GO:0050821 | protein stabilization |
| GO:0042481 | regulation of odontogenesis |
| GO:0060021 | roof of mouth development |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0048863 | stem cell differentiation |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |