| Tag | Content |
|---|---|
| Uniprot ID | G3V6U7 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000009101 |
| Ensembl nucleotide ID | ENSRNOG00000006876 |
| Gene name | Msh homeobox 1 |
| Gene symbol | Msx1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTSLPLGVKV EDSAFAKPAG GGAGQAPGAA AATATAMGTD EEGAKPKVPA SLLPFSVEAL 60 MADHRKPGAK ESVLVASEGA QAAGGSVQHL GTRPGSLGAP DAPSSPRPLG HFSVGGLLKL 120 PEDALVKAES PEKLDRTPWM QSPRFSPPPA RRLSPPACTL RKHKTNRKPR TPFTTAQLLA 180 LERKFRQKQY LSIAERAEFS SSLSLTETQV KIWFQNRRAK AKRLQEAELE KLKMAAKPML 240 PPAAFGLSFP LGGPAAVAAA AGASLYSASG PFQRAALPVA PVGLYTAHVG YSMYHLT 297 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSX1 | 102190677 | A0A452EK01 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSX1 | 4487 | P28360 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Msx1 | 17701 | P13297 | CPO,CLP | E11.5, E13.0, E12.5, E14.0, E13.5, E14.5, E15.0, E15.5, E16.0 | Mus musculus | Publication | More>> |
| 1:1 ortholog | MSX1 | 461092 | Q2VL88 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSX1 | F1S5G6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Msx1 | G3V6U7 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | msx1a | B3DG59 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0035326 | cis-regulatory region binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0002039 | p53 binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0090427 | activation of meiosis |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0030509 | BMP signaling pathway |
| GO:0061312 | BMP signaling pathway involved in heart development |
| GO:0060349 | bone morphogenesis |
| GO:0051216 | cartilage development |
| GO:0060536 | cartilage morphogenesis |
| GO:0000902 | cell morphogenesis |
| GO:0071316 | cellular response to nicotine |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048598 | embryonic morphogenesis |
| GO:0035880 | embryonic nail plate morphogenesis |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0060325 | face morphogenesis |
| GO:0030900 | forebrain development |
| GO:0007507 | heart development |
| GO:0003007 | heart morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0061180 | mammary gland epithelium development |
| GO:0010463 | mesenchymal cell proliferation |
| GO:0030901 | midbrain development |
| GO:0042474 | middle ear morphogenesis |
| GO:0007517 | muscle organ development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0030308 | negative regulation of cell growth |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0043392 | negative regulation of DNA binding |
| GO:0051154 | negative regulation of striated muscle cell differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:2000678 | negative regulation of transcription regulatory region DNA binding |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0042476 | odontogenesis |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0021983 | pituitary gland development |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:2001055 | positive regulation of mesenchymal cell apoptotic process |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0034504 | protein localization to nucleus |
| GO:0050821 | protein stabilization |
| GO:0042481 | regulation of odontogenesis |
| GO:0060021 | roof of mouth development |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0048863 | stem cell differentiation |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |