Gene: Msx1

Basic information

Tag Content
Uniprot ID G3V6U7
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSRNOP00000009101
Ensembl nucleotide ID ENSRNOG00000006876
Gene name Msh homeobox 1
Gene symbol Msx1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTSLPLGVKV EDSAFAKPAG GGAGQAPGAA AATATAMGTD EEGAKPKVPA SLLPFSVEAL 60
MADHRKPGAK ESVLVASEGA QAAGGSVQHL GTRPGSLGAP DAPSSPRPLG HFSVGGLLKL 120
PEDALVKAES PEKLDRTPWM QSPRFSPPPA RRLSPPACTL RKHKTNRKPR TPFTTAQLLA 180
LERKFRQKQY LSIAERAEFS SSLSLTETQV KIWFQNRRAK AKRLQEAELE KLKMAAKPML 240
PPAAFGLSFP LGGPAAVAAA AGASLYSASG PFQRAALPVA PVGLYTAHVG YSMYHLT 297

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMSX1102190677A0A452EK01Capra hircusPredictionMore>>
1:1 orthologMSX14487P28360CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologMsx117701P13297CPO,CLPE11.5, E13.0, E12.5, E14.0, E13.5, E14.5, E15.0, E15.5, E16.0Mus musculusPublicationMore>>
1:1 orthologMSX1461092Q2VL88Pan troglodytesPredictionMore>>
1:1 orthologMSX1F1S5G6Sus scrofaPredictionMore>>
1:1 orthologMsx1G3V6U7Rattus norvegicusPredictionMore>>
1:1 orthologmsx1aB3DG59Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0035326 cis-regulatory region binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0002039 p53 binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0090427 activation of meiosis
GO:0009952 anterior/posterior pattern specification
GO:0030509 BMP signaling pathway
GO:0061312 BMP signaling pathway involved in heart development
GO:0060349 bone morphogenesis
GO:0051216 cartilage development
GO:0060536 cartilage morphogenesis
GO:0000902 cell morphogenesis
GO:0071316 cellular response to nicotine
GO:0042733 embryonic digit morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0030326 embryonic limb morphogenesis
GO:0048598 embryonic morphogenesis
GO:0035880 embryonic nail plate morphogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0060325 face morphogenesis
GO:0030900 forebrain development
GO:0007507 heart development
GO:0003007 heart morphogenesis
GO:0001701 in utero embryonic development
GO:0061180 mammary gland epithelium development
GO:0010463 mesenchymal cell proliferation
GO:0030901 midbrain development
GO:0042474 middle ear morphogenesis
GO:0007517 muscle organ development
GO:0043066 negative regulation of apoptotic process
GO:0030308 negative regulation of cell growth
GO:0008285 negative regulation of cell population proliferation
GO:0043392 negative regulation of DNA binding
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0042476 odontogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0021983 pituitary gland development
GO:0030513 positive regulation of BMP signaling pathway
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:2001055 positive regulation of mesenchymal cell apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0034504 protein localization to nucleus
GO:0050821 protein stabilization
GO:0042481 regulation of odontogenesis
GO:0060021 roof of mouth development
GO:0023019 signal transduction involved in regulation of gene expression
GO:0048863 stem cell differentiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain