| Tag | Content |
|---|---|
| Uniprot ID | A0A452EY65 |
| Entrez ID | 102174804 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018046554.1 |
| Ensembl protein ID | ENSCHIP00000016997 |
| Ensembl nucleotide ID | ENSCHIG00000017047 |
| Gene name | Homeobox domain-containing protein |
| Gene symbol | GBX2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP 60 PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL TSTLMATLPG GFSASPQHQE 120 AAAARKFAPQ QLPGGGGNFD KAEALQADSE DGKGFLAKEG SLLAFSAAEA VQASLVGAVR 180 GQGKDESKVE DDPKGKEESF SLESDLDYSS DDNLPGQAAH KEEDPGHALE ETPPSGGAAG 240 STTSTGKNRR RRTAFTSEQL LELEKEFHCK KYLSLTERSQ IAHALKLSEV QVKIWFQNRR 300 AKWKRVKAGN ANSKTGEPSR NPKIVVPIPV HVSRFAIRSQ HQQLEQARP 349 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GBX2 | 486174 | E2RC01 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 102174804 | A0A452EY65 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 2637 | P52951 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gbx2 | 14472 | P48031 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GBX2 | 470689 | H2QJN8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 100514608 | F1SM11 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 100353889 | G1T4M0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gbx2 | 114500 | G3V8J6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gbx2 | 245948 | Q8QGU1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0048483 | autonomic nervous system development |
| GO:0007411 | axon guidance |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0021930 | cerebellar granule cell precursor proliferation |
| GO:0021549 | cerebellum development |
| GO:0021884 | forebrain neuron development |
| GO:0042472 | inner ear morphogenesis |
| GO:0021555 | midbrain-hindbrain boundary morphogenesis |
| GO:0001755 | neural crest cell migration |
| GO:0021568 | rhombomere 2 development |
| GO:0021794 | thalamus development |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |