Gene: gbx2

Basic information

Tag Content
Uniprot ID Q8QGU1
Entrez ID 245948
Genbank protein ID AAH59413.1; BAB88556.1;
Genbank nucleotide ID NM_152964.1
Ensembl protein ID ENSDARP00000151315; ENSDARP00000004972;
Ensembl nucleotide ID ENSDARG00000002933; ENSDARG00000116377;
Gene name Gastrulation brain homeo box 2
Gene symbol gbx2
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSAAFSTPFM MMQRPVGSTT AFSIDSLIGG PPQPSPGHFV YTGYPMFMPY RSVVLPPPPP 60
PPPPTLPQSA LPTTHPHHPI PGLPSSFCSS LAQGMALTST LMATLPGGFS SSPSQQHQDA 120
ARKLGSQSIH AMFDKSQDIR LDGEDGKTFA TKDSTSIPSF HDSQSVHTST VRGHSKDDSK 180
EDDCHRKDES FSMDSDLDYS SDDNGPGNAM CQKEDGDGSG GLDDGVHGGN GAGNTTSTGK 240
NRRRRTAFTS EQLLELEKEF HCKKYLSLTE RSQIAHALKL SEVQVKIWFQ NRRAKWKRVK 300
AGNVNSKTGE PSRNPKIVVP IPVHVSRFAI RSQHQQLEQA RP 342

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGBX2486174E2RC01Canis lupus familiarisPredictionMore>>
1:1 orthologGBX2102174804A0A452EY65Capra hircusPredictionMore>>
1:1 orthologGBX22637P52951Homo sapiensPredictionMore>>
1:1 orthologGbx214472P48031CPOMus musculusPublicationMore>>
1:1 orthologGBX2470689H2QJN8Pan troglodytesPredictionMore>>
1:1 orthologGBX2100514608F1SM11Sus scrofaPredictionMore>>
1:1 orthologGBX2100353889G1T4M0Oryctolagus cuniculusPredictionMore>>
1:1 orthologGbx2114500G3V8J6Rattus norvegicusPredictionMore>>
1:1 orthologgbx2245948Q8QGU1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0021549 cerebellum development
GO:0030902 hindbrain development
GO:0050935 iridophore differentiation
GO:0051960 regulation of nervous system development
GO:0006357 regulation of transcription by RNA polymerase II
GO:0021978 telencephalon regionalization

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR042982 GBX-1/2
IPR031250 GBX-2
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain