| Tag | Content |
|---|---|
| Uniprot ID | H2QJN8; A0A2J8NEJ8; |
| Entrez ID | 470689 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_526072.5 |
| Ensembl protein ID | ENSPTRP00000022357 |
| Ensembl nucleotide ID | ENSPTRG00000013068 |
| Gene name | Gastrulation brain homeobox 2 |
| Gene symbol | GBX2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP 60 PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL TSTLMATLPG GFSASPQHQE 120 AAAARKFAPQ PLPGGGNFDK AEALQADAED GKGFLAKEGS LLAFSAAEAV QASLVGAVRG 180 QGKDESKVED DPKGKEESFS LESDVDYSSD DNLTGQAAHK EEDPGHALEE TPPSSGAAGS 240 TTSTGKNRRR RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA 300 KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP 348 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GBX2 | 486174 | E2RC01 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 102174804 | A0A452EY65 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 2637 | P52951 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gbx2 | 14472 | P48031 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GBX2 | 470689 | H2QJN8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 100514608 | F1SM11 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | GBX2 | 100353889 | G1T4M0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gbx2 | 114500 | G3V8J6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gbx2 | 245948 | Q8QGU1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0048483 | autonomic nervous system development |
| GO:0007411 | axon guidance |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0021930 | cerebellar granule cell precursor proliferation |
| GO:0021549 | cerebellum development |
| GO:0021884 | forebrain neuron development |
| GO:0030902 | hindbrain development |
| GO:0042472 | inner ear morphogenesis |
| GO:0021555 | midbrain-hindbrain boundary morphogenesis |
| GO:0001755 | neural crest cell migration |
| GO:0051960 | regulation of nervous system development |
| GO:0021568 | rhombomere 2 development |
| GO:0021794 | thalamus development |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |