Gene: WNT11

Basic information

Tag Content
Uniprot ID A0A452FJS3
Entrez ID 102175498
Genbank protein ID
Genbank nucleotide ID XM_018059328.1
Ensembl protein ID ENSCHIP00000024696
Ensembl nucleotide ID ENSCHIG00000021782
Gene name Protein Wnt
Gene symbol WNT11
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Ligand for members of the frizzled family of seven transmembrane receptors.
Sequence
MRARPQVCQA LLFALALQTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG LVSAQVQLCR 60
SNLELMHTIV HAAREVMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 120
AISHAIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 180
TGSQANKLMR LHNSEVGRQA LRASLEMKCK CHGVSGSCSI RTCWKGLQEL RDVAADLKTR 240
YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 300
KTSHGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK 354

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologWNT11613288F1N4C0Bos taurusPredictionMore>>
1:1 orthologWNT11485183E2QXQ3Canis lupus familiarisPredictionMore>>
1:1 orthologWNT11102175498A0A452FJS3Capra hircusPredictionMore>>
1:1 orthologWNT117481O96014Homo sapiensPublicationMore>>
1:1 orthologWnt1122411P48615CPOE14.5Mus musculusPublicationMore>>
1:1 orthologWNT11451431H2Q4F7Pan troglodytesPredictionMore>>
1:1 orthologWNT11I3L5C2Sus scrofaPredictionMore>>
1:1 orthologWnt-11100009030Q27Q51Oryctolagus cuniculusPredictionMore>>
1:1 orthologWnt11140584G3V819Rattus norvegicusPredictionMore>>
1:1 orthologwnt1130283Q9I9I2Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
GO:0005096 GTPase activator activity
GO:0030295 protein kinase activator activity
GO:0005102 signaling receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0030325 adrenal gland development
GO:0048844 artery morphogenesis
GO:0003283 atrial septum development
GO:0070830 bicellular tight junction assembly
GO:0030282 bone mineralization
GO:0060070 canonical Wnt signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0060197 cloacal septation
GO:0060028 convergent extension involved in axis elongation
GO:0048706 embryonic skeletal system development
GO:0001837 epithelial to mesenchymal transition
GO:0060484 lung-associated mesenchyme development
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0072177 mesonephric duct development
GO:0043066 negative regulation of apoptotic process
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0090272 negative regulation of fibroblast growth factor production
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0061101 neuroendocrine cell differentiation
GO:0048570 notochord morphogenesis
GO:0001649 osteoblast differentiation
GO:0003151 outflow tract morphogenesis
GO:0048341 paraxial mesoderm formation
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation
GO:0043065 positive regulation of apoptotic process
GO:0030335 positive regulation of cell migration
GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
GO:0090037 positive regulation of protein kinase C signaling
GO:0051496 positive regulation of stress fiber assembly
GO:0045893 positive regulation of transcription, DNA-templated
GO:0032915 positive regulation of transforming growth factor beta2 production
GO:0003138 primary heart field specification
GO:0034394 protein localization to cell surface
GO:0006468 protein phosphorylation
GO:0003139 secondary heart field specification
GO:0062009 secondary palate development
GO:0061053 somite development
GO:0060675 ureteric bud morphogenesis
GO:0060412 ventricular septum morphogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0272 Extracellular matrix
KW-1185 Reference proteome
KW-0964 Secreted
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR005817 Wnt
IPR026536 Wnt-11
IPR043158 Wnt_C
IPR018161 Wnt_CS

PROSITE

PROSITE ID PROSITE Term
PS00246 WNT1

Pfam

Pfam ID Pfam Term
PF00110 wnt