CleftGeneDB-Search

Gene: Wnt11

Basic information

Tag	Content
Uniprot ID	P48615
Entrez ID	22411
Genbank protein ID	CAA50070.1
Genbank nucleotide ID	XM_006507586.3; NM_001285792.1; NM_009519.2;
Ensembl protein ID	ENSMUSP00000132166; ENSMUSP00000064333;
Ensembl nucleotide ID	ENSMUSG00000015957
Gene name	Protein Wnt-11
Gene symbol	Wnt11
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO
Developmental stage	E14.5
Data sources	Manually collected
Reference	23095888
Functional description	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Sequence	MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG LVSAQVQLCR 60 SNLELMRTIV HAARGAMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 120 TISHTIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 180 TGSQANKLMR LHNSEVGRQA LRASLETKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR 240 YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 300 KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK 354

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	WNT11	613288	F1N4C0			Bos taurus	Prediction	More>>
1:1 ortholog	WNT11	485183	E2QXQ3			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	WNT11	102175498	A0A452FJS3			Capra hircus	Prediction	More>>
1:1 ortholog	WNT11	7481	O96014			Homo sapiens	Publication	More>>
1:1 ortholog	Wnt11	22411	P48615	CPO	E14.5	Mus musculus	Publication	More>>
1:1 ortholog	WNT11	451431	H2Q4F7			Pan troglodytes	Prediction	More>>
1:1 ortholog	WNT11		I3L5C2			Sus scrofa	Prediction	More>>
1:1 ortholog	Wnt-11	100009030	Q27Q51			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Wnt11	140584	G3V819			Rattus norvegicus	Prediction	More>>
1:1 ortholog	wnt11	30283	Q9I9I2			Danio rerio	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
WNT11	rs66374	Genotyping; PDT; and APL	18413325
WNT11	rs7936750*G	Genotyping	26602496

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005096	GTPase activator activity	ISS
GO:0005096	GTPase activator activity	ISO
GO:0005102	signaling receptor binding	TAS
GO:0005109	frizzled binding	IBA
GO:0005515	protein binding	IPI
GO:0030295	protein kinase activator activity	ISS
GO:0030295	protein kinase activator activity	ISO
GO:0044212	transcription regulatory region DNA binding	ISS
GO:0044212	transcription regulatory region DNA binding	ISO

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001649	osteoblast differentiation	IGI
GO:0001822	kidney development	IDA
GO:0001837	epithelial to mesenchymal transition	IGI
GO:0003138	primary heart field specification	IGI
GO:0003139	secondary heart field specification	IGI
GO:0003151	outflow tract morphogenesis	IMP
GO:0003281	ventricular septum development	IGI
GO:0003283	atrial septum development	IGI
GO:0003402	planar cell polarity pathway involved in axis elongation	IGI
GO:0006468	protein phosphorylation	ISS
GO:0006468	protein phosphorylation	ISO
GO:0007165	signal transduction	TAS
GO:0007267	cell-cell signaling	TAS
GO:0009887	animal organ morphogenesis	TAS
GO:0010628	positive regulation of gene expression	ISS
GO:0010628	positive regulation of gene expression	ISO
GO:0016055	Wnt signaling pathway	IBA
GO:0030182	neuron differentiation	IBA
GO:0030282	bone mineralization	IGI
GO:0030308	negative regulation of cell growth	ISS
GO:0030308	negative regulation of cell growth	ISO
GO:0030325	adrenal gland development	IEA
GO:0030335	positive regulation of cell migration	ISS
GO:0030335	positive regulation of cell migration	ISO
GO:0030336	negative regulation of cell migration	ISS
GO:0030336	negative regulation of cell migration	ISO
GO:0031667	response to nutrient levels	IEA
GO:0032147	activation of protein kinase activity	IEA
GO:0032915	positive regulation of transforming growth factor beta2 production	IMP
GO:0034394	protein localization to cell surface	ISS
GO:0034394	protein localization to cell surface	ISO
GO:0035567	non-canonical Wnt signaling pathway	IMP
GO:0043065	positive regulation of apoptotic process	IMP
GO:0043066	negative regulation of apoptotic process	ISS
GO:0043066	negative regulation of apoptotic process	ISO
GO:0043547	positive regulation of GTPase activity	ISS
GO:0043547	positive regulation of GTPase activity	ISO
GO:0045165	cell fate commitment	IBA
GO:0045199	maintenance of epithelial cell apical/basal polarity	IGI
GO:0045892	negative regulation of transcription, DNA-templated	ISS
GO:0045892	negative regulation of transcription, DNA-templated	ISO
GO:0045893	positive regulation of transcription, DNA-templated	ISS
GO:0045893	positive regulation of transcription, DNA-templated	ISO
GO:0048341	paraxial mesoderm formation	IGI
GO:0048570	notochord morphogenesis	IGI
GO:0048706	embryonic skeletal system development	IEA
GO:0048844	artery morphogenesis	IMP
GO:0051496	positive regulation of stress fiber assembly	ISS
GO:0051496	positive regulation of stress fiber assembly	ISO
GO:0060021	roof of mouth development	IMP
GO:0060028	convergent extension involved in axis elongation	IGI
GO:0060070	canonical Wnt signaling pathway	IDA
GO:0060197	cloacal septation	IEA
GO:0060412	ventricular septum morphogenesis	IMP
GO:0060484	lung-associated mesenchyme development	IEA
GO:0060548	negative regulation of cell death	ISS
GO:0060548	negative regulation of cell death	ISO
GO:0060675	ureteric bud morphogenesis	IEA
GO:0060775	planar cell polarity pathway involved in gastrula mediolateral intercalation	IGI
GO:0061053	somite development	IGI
GO:0061101	neuroendocrine cell differentiation	ISS
GO:0061101	neuroendocrine cell differentiation	ISO
GO:0062009	secondary palate development	ISS
GO:0062009	secondary palate development	ISO
GO:0070830	bicellular tight junction assembly	IMP
GO:0071260	cellular response to mechanical stimulus	IDA
GO:0072177	mesonephric duct development	IEA
GO:0072201	negative regulation of mesenchymal cell proliferation	IMP
GO:0090037	positive regulation of protein kinase C signaling	ISS
GO:0090037	positive regulation of protein kinase C signaling	ISO
GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	IGI
GO:0090090	negative regulation of canonical Wnt signaling pathway	ISS
GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO
GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA
GO:0090272	negative regulation of fibroblast growth factor production	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	IDA
GO:0005615	extracellular space	IBA
GO:0005737	cytoplasm	ISS
GO:0005737	cytoplasm	ISO
GO:0031012	extracellular matrix	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-162582	Signal Transduction	IEA
R-MMU-195721	Signaling by WNT	IEA
R-MMU-3238698	WNT ligand biogenesis and trafficking	IEA
R-MMU-3858494	Beta-catenin independent WNT signaling	IEA
R-MMU-4086398	Ca2+ pathway	IEA
R-MMU-4086400	PCP/CE pathway	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0217	Developmental protein
KW-1015	Disulfide bond
KW-0272	Extracellular matrix
KW-0325	Glycoprotein
KW-0449	Lipoprotein
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR005817	Wnt
IPR026536	Wnt-11
IPR043158	Wnt_C
IPR018161	Wnt_CS

PROSITE

PROSITE ID	PROSITE Term
PS00246	WNT1

Pfam

Pfam ID	Pfam Term
PF00110	wnt

Gene: Wnt11

Basic information

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction