| Tag | Content |
|---|---|
| Uniprot ID | G3V819 |
| Entrez ID | 140584 |
| Genbank protein ID | EDM18428.1; EDM18427.1; EDM18429.1; |
| Genbank nucleotide ID | XM_006229720.3; XM_006229719.3; NM_080401.1; XM_006229718.3; |
| Ensembl protein ID | ENSRNOP00000021674 |
| Ensembl nucleotide ID | ENSRNOG00000015982 |
| Gene name | Protein Wnt |
| Gene symbol | Wnt11 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors. |
| Sequence | MRARPQVCEA LLFALALHTG VCYGIKWLAL SKTPAALALN QTQHCKQLEG LVSAQVQLCR 60 SNLELMRTIV HAAREAMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 120 TISHTIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 180 TGSQANKLMR LHNSEVGRQA LRASLETKCK CHGVSGSCSI RTCWKGLQEL RDVAADLKTR 240 YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 300 KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK 354 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT11 | 613288 | F1N4C0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | WNT11 | 485183 | E2QXQ3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | WNT11 | 102175498 | A0A452FJS3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | WNT11 | 7481 | O96014 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Wnt11 | 22411 | P48615 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | WNT11 | 451431 | H2Q4F7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | WNT11 | I3L5C2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Wnt-11 | 100009030 | Q27Q51 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wnt11 | 140584 | G3V819 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | wnt11 | 30283 | Q9I9I2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0031012 | extracellular matrix |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0005109 | frizzled binding |
| GO:0005096 | GTPase activator activity |
| GO:0030295 | protein kinase activator activity |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0030325 | adrenal gland development |
| GO:0048844 | artery morphogenesis |
| GO:0003283 | atrial septum development |
| GO:0070830 | bicellular tight junction assembly |
| GO:0030282 | bone mineralization |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0030154 | cell differentiation |
| GO:0045165 | cell fate commitment |
| GO:0071260 | cellular response to mechanical stimulus |
| GO:0060197 | cloacal septation |
| GO:0060028 | convergent extension involved in axis elongation |
| GO:0048706 | embryonic skeletal system development |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0001822 | kidney development |
| GO:0060484 | lung-associated mesenchyme development |
| GO:0045199 | maintenance of epithelial cell apical/basal polarity |
| GO:0072177 | mesonephric duct development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0060548 | negative regulation of cell death |
| GO:0030308 | negative regulation of cell growth |
| GO:0030336 | negative regulation of cell migration |
| GO:0090272 | negative regulation of fibroblast growth factor production |
| GO:0072201 | negative regulation of mesenchymal cell proliferation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0061101 | neuroendocrine cell differentiation |
| GO:0030182 | neuron differentiation |
| GO:0035567 | non-canonical Wnt signaling pathway |
| GO:0048570 | notochord morphogenesis |
| GO:0001649 | osteoblast differentiation |
| GO:0003151 | outflow tract morphogenesis |
| GO:0048341 | paraxial mesoderm formation |
| GO:0003402 | planar cell polarity pathway involved in axis elongation |
| GO:0060775 | planar cell polarity pathway involved in gastrula mediolateral intercalation |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0030335 | positive regulation of cell migration |
| GO:0010628 | positive regulation of gene expression |
| GO:0043547 | positive regulation of GTPase activity |
| GO:0090082 | positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway |
| GO:0090037 | positive regulation of protein kinase C signaling |
| GO:0051496 | positive regulation of stress fiber assembly |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0032915 | positive regulation of transforming growth factor beta2 production |
| GO:0003138 | primary heart field specification |
| GO:0034394 | protein localization to cell surface |
| GO:0006468 | protein phosphorylation |
| GO:0031667 | response to nutrient levels |
| GO:0060021 | roof of mouth development |
| GO:0003139 | secondary heart field specification |
| GO:0062009 | secondary palate development |
| GO:0061053 | somite development |
| GO:0060675 | ureteric bud morphogenesis |
| GO:0060412 | ventricular septum morphogenesis |
| GO:0016055 | Wnt signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |