| Tag | Content |
|---|---|
| Uniprot ID | A0A452FZS6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000029867 |
| Ensembl nucleotide ID | ENSCHIG00000024821 |
| Gene name | Platelet-derived growth factor receptor beta |
| Gene symbol | PDGFRB |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. |
| Sequence | MRLPSALRAA VLKGQVLLLL LLFLLGPRAS GGLVIIPPGP ELVLNLSSTF VLTCSGPAPV 60 VWERMSQKPP QEMTETPDGT FSSVLTLVNV TGLDTGEYFC GYKGSHGLEA SERKRLYIFV 120 PDPSVGFLPV DPEELFIFLT EITETTIPCR VTDPRLVVML HEKKVDVPLP IAYDPQRGFS 180 GTFEDKTYIC KTTIGDREVD SDAYHVYSLQ VSSINVSVNA VQTVVRQGEN ITIMCIVTGN 240 EVVNFEWTYP RMESGRLVEP VTDFLFEMPH IRSILHIPSA ELGDSGTYIC NVSESVSDHR 300 DEKAINVTVV ENGYVRLLGE LDPVQFAELH RSRTLQVVFE AYPPPTVMWF KDNRTLGDSS 360 AGEIVLSTRN VSETRYVSEL TLVRVKVAEA GYYTMRAFHE DAEAQLSFQL QVNVPVRVLE 420 LSESHPANGE QTVRCRGRGM PQPHLTWSTC SDLKRCPREL PPTPLGNSSE EESQLETNVT 480 YWAEEQEFEV VSTLRLRHVD QPLSVRCTLH NLLGYDVQEV TVVPHSLPFK VVVISAILAL 540 VVLTIISLII LIMLWQKKPR YEIRWKVIES VSSDGHEYIY VDPMQLPYDS TWELPRDQLV 600 LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 660 LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRCSDKRRPP SAELYSNALP 720 VGLPLPSHVS LPGESDGGYM DMSKDESVDY VPMLDMKGDV KYADIESSNY MAPYDNYVPS 780 APERTCRVTL INESPVLSYT DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK 840 ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 900 TPYPELPMNE QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFEIRPPF SQLVLLLERL 960 LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR LPGFSGLRSP LDTSSVLYTA VQPNEGDNDY 1020 IIPLPDPKPE VADEGPLEGS PSLASSTLNE VNTSSTISCD SPLEPQEEPE PQLCPGPRAE 1080 AEDSFL 1086 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRB | 527165 | F1N759 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRB | A0A452FZS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PDGFRB | 5159 | P09619 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfrb | 18596 | P05622 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PDGFRB | A0A2I3T367 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480LAB1 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Pdgfrb | 24629 | Q05030 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031410 | cytoplasmic vesicle |
| GO:0016021 | integral component of membrane |
| GO:0043202 | lysosomal lumen |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0005019 | platelet-derived growth factor beta-receptor activity |
| GO:0006935 | chemotaxis |
| GO:0007275 | multicellular organism development |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0458 | Lysosome |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR027288 | PGFRB |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |