| Tag | Content |
|---|---|
| Uniprot ID | P05622; E9QPE2; |
| Entrez ID | 18596 |
| Genbank protein ID | CAA27882.1 |
| Genbank nucleotide ID | NM_001146268.1; NM_008809.2; |
| Ensembl protein ID | ENSMUSP00000025522 |
| Ensembl nucleotide ID | ENSMUSG00000024620 |
| Gene name | Platelet-derived growth factor receptor beta |
| Gene symbol | Pdgfrb |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 27856617; 17499702; |
| Functional description | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM (By similarity). Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. |
| Sequence | MGLPGVIPAL VLRGQLLLSV LWLLGPQTSR GLVITPPGPE FVLNISSTFV LTCSGSAPVM 60 WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV YNNSLGPELS ERKRIYIFVP 120 DPTMGFLPMD SEDLFIFVTD VTETTIPCRV TDPQLEVTLH EKKVDIPLHV PYDHQRGFTG 180 TFEDKTYICK TTIGDREVDS DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND 240 VVNFQWTYPR MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG 300 DEKAINISVI ENGYVRLLET LGDVEIAELH RSRTLRVVFE AYPMPSVLWL KDNRTLGDSG 360 AGELVLSTRN MSETRYVSEL ILVRVKVSEA GYYTMRAFHE DDEVQLSFKL QVNVPVRVLE 420 LSESHPANGE QTIRCRGRGM PQPNVTWSTC RDLKRCPRKL SPTPLGNSSK EESQLETNVT 480 FWEEDQEYEV VSTLRLRHVD QPLSVRCMLQ NSMGGDSQEV TVVPHSLPFK VVVISAILAL 540 VVLTVISLII LIMLWQKKPR YEIRWKVIES VSSDGHEYIY VDPVQLPYDS TWELPRDQLV 600 LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 660 LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRHSNKHCPP SAELYSNALP 720 VGFSLPSHLN LTGESDGGYM DMSKDESIDY VPMLDMKGDI KYADIESPSY MAPYDNYVPS 780 APERTYRATL INDSPVLSYT DLVGFSYQVA NGMDFLASKN CVHRDLAARN VLICEGKLVK 840 ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 900 TPYPELPMND QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFETRPPF SQLVLLLERL 960 LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR FPGIHSLRSP LDTSSVLYTA VQPNESDNDY 1020 IIPLPDPKPD VADEGLPEGS PSLASSTLNE VNTSSTISCD SPLELQEEPQ QAEPEAQLEQ 1080 PQDSGCPGPL AEAEDSFL 1098 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRB | 527165 | F1N759 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRB | A0A452FZS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PDGFRB | 5159 | P09619 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfrb | 18596 | P05622 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PDGFRB | A0A2I3T367 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480LAB1 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Pdgfrb | 24629 | Q05030 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | ISS |
| GO:0004713 | protein tyrosine kinase activity | ISO |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA |
| GO:0005017 | platelet-derived growth factor-activated receptor activity | ISO |
| GO:0005017 | platelet-derived growth factor-activated receptor activity | IBA |
| GO:0005019 | platelet-derived growth factor beta-receptor activity | ISS |
| GO:0005019 | platelet-derived growth factor beta-receptor activity | ISO |
| GO:0005019 | platelet-derived growth factor beta-receptor activity | IBA |
| GO:0005102 | signaling receptor binding | ISO |
| GO:0005102 | signaling receptor binding | IPI |
| GO:0005161 | platelet-derived growth factor receptor binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0016301 | kinase activity | IMP |
| GO:0019838 | growth factor binding | IBA |
| GO:0019899 | enzyme binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0038085 | vascular endothelial growth factor binding | ISO |
| GO:0043548 | phosphatidylinositol 3-kinase binding | ISO |
| GO:0048407 | platelet-derived growth factor binding | ISO |
| GO:0048407 | platelet-derived growth factor binding | TAS |
| GO:0048407 | platelet-derived growth factor binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001568 | blood vessel development | IEP |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001822 | kidney development | IMP |
| GO:0001894 | tissue homeostasis | IMP |
| GO:0002244 | hematopoietic progenitor cell differentiation | IBA |
| GO:0006024 | glycosaminoglycan biosynthetic process | ISO |
| GO:0006807 | nitrogen compound metabolic process | IMP |
| GO:0007165 | signal transduction | ISO |
| GO:0007165 | signal transduction | IDA |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA |
| GO:0007275 | multicellular organism development | IBA |
| GO:0007568 | aging | IEA |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008584 | male gonad development | IEA |
| GO:0010863 | positive regulation of phospholipase C activity | ISO |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | IDA |
| GO:0014911 | positive regulation of smooth muscle cell migration | ISO |
| GO:0014911 | positive regulation of smooth muscle cell migration | IMP |
| GO:0014911 | positive regulation of smooth muscle cell migration | IGI |
| GO:0014911 | positive regulation of smooth muscle cell migration | IBA |
| GO:0016477 | cell migration | ISO |
| GO:0018108 | peptidyl-tyrosine phosphorylation | ISS |
| GO:0018108 | peptidyl-tyrosine phosphorylation | ISO |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA |
| GO:0030325 | adrenal gland development | IGI |
| GO:0030335 | positive regulation of cell migration | ISS |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0032355 | response to estradiol | IEA |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity | ISO |
| GO:0032526 | response to retinoic acid | IEA |
| GO:0032956 | regulation of actin cytoskeleton organization | IGI |
| GO:0032967 | positive regulation of collagen biosynthetic process | ISO |
| GO:0033674 | positive regulation of kinase activity | IBA |
| GO:0034405 | response to fluid shear stress | IEA |
| GO:0035025 | positive regulation of Rho protein signal transduction | ISO |
| GO:0035441 | cell migration involved in vasculogenesis | IMP |
| GO:0035556 | intracellular signal transduction | ISO |
| GO:0035789 | metanephric mesenchymal cell migration | ISO |
| GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway | ISO |
| GO:0035793 | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway | IMP |
| GO:0035909 | aorta morphogenesis | IGI |
| GO:0036120 | cellular response to platelet-derived growth factor stimulus | IEA |
| GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | ISS |
| GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | ISO |
| GO:0042060 | wound healing | IEA |
| GO:0043065 | positive regulation of apoptotic process | ISO |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0043406 | positive regulation of MAP kinase activity | IDA |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | ISS |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | ISO |
| GO:0043627 | response to estrogen | IEA |
| GO:0045840 | positive regulation of mitotic nuclear division | IDA |
| GO:0046488 | phosphatidylinositol metabolic process | ISO |
| GO:0046777 | protein autophosphorylation | ISS |
| GO:0046777 | protein autophosphorylation | ISO |
| GO:0046777 | protein autophosphorylation | IDA |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | ISO |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IMP |
| GO:0048015 | phosphatidylinositol-mediated signaling | ISO |
| GO:0048146 | positive regulation of fibroblast proliferation | ISO |
| GO:0048568 | embryonic organ development | IEP |
| GO:0048661 | positive regulation of smooth muscle cell proliferation | ISO |
| GO:0048661 | positive regulation of smooth muscle cell proliferation | IMP |
| GO:0048705 | skeletal system morphogenesis | IMP |
| GO:0048745 | smooth muscle tissue development | IMP |
| GO:0048839 | inner ear development | IEA |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | IMP |
| GO:0050921 | positive regulation of chemotaxis | IDA |
| GO:0055003 | cardiac myofibril assembly | IGI |
| GO:0055093 | response to hyperoxia | IEA |
| GO:0060326 | cell chemotaxis | ISS |
| GO:0060326 | cell chemotaxis | ISO |
| GO:0060437 | lung growth | ISO |
| GO:0060947 | cardiac vascular smooth muscle cell differentiation | TAS |
| GO:0060981 | cell migration involved in coronary angiogenesis | IMP |
| GO:0061298 | retina vasculature development in camera-type eye | IGI |
| GO:0061298 | retina vasculature development in camera-type eye | IMP |
| GO:0070301 | cellular response to hydrogen peroxide | IMP |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IMP |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IDA |
| GO:0071670 | smooth muscle cell chemotaxis | IGI |
| GO:0072075 | metanephric mesenchyme development | IEA |
| GO:0072223 | metanephric glomerular mesangium development | IEP |
| GO:0072262 | metanephric glomerular mesangial cell proliferation involved in metanephros development | IMP |
| GO:0072277 | metanephric glomerular capillary formation | IGI |
| GO:0072278 | metanephric comma-shaped body morphogenesis | IEA |
| GO:0072284 | metanephric S-shaped body morphogenesis | IEA |
| GO:0090280 | positive regulation of calcium ion import | IMP |
| GO:0106096 | response to ceramide | IMP |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | IMP |
| GO:2000491 | positive regulation of hepatic stellate cell activation | ISO |
| GO:2000573 | positive regulation of DNA biosynthetic process | IMP |
| GO:0030097 | hemopoiesis | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005886 | plasma membrane | ISS |
| GO:0005886 | plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0009986 | cell surface | ISO |
| GO:0009986 | cell surface | IDA |
| GO:0016020 | membrane | ISO |
| GO:0016324 | apical plasma membrane | ISS |
| GO:0016324 | apical plasma membrane | ISO |
| GO:0031226 | intrinsic component of plasma membrane | ISO |
| GO:0031410 | cytoplasmic vesicle | IEA |
| GO:0043202 | lysosomal lumen | IEA |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0043235 | receptor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-186763 | Downstream signal transduction | IEA |
| R-MMU-186797 | Signaling by PDGF | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-5673001 | RAF/MAP kinase cascade | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0458 | Lysosome |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR027288 | PGFRB |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |