| Tag | Content |
|---|---|
| Uniprot ID | F1N759 |
| Entrez ID | 527165 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001075896.2 |
| Ensembl protein ID | ENSBTAP00000053664 |
| Ensembl nucleotide ID | ENSBTAG00000002804 |
| Gene name | Platelet-derived growth factor receptor beta |
| Gene symbol | PDGFRB |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. |
| Sequence | MWLPSAMQAV VLKGRVLLLP LLFLLGPQAS WGLAIIPPGP ELVLNLSSTF VLTCSGPAPV 60 VWERMSQKPP QEMTETQDGT FSSVLTLVNV TGLDTGEYFC GYKRSHGLEA SERKRLYIFV 120 PDPSVGFLPV DPEELFIFLT EITETTIPCR VTDPRLVVML HEKKVDVPLP IAYDPQRGFS 180 GTFEDKTYIC KTTIGDREVD SDAYHVYSLQ VSSINVSVNA VQTVVRQGEN ITIMCIVTGN 240 EVVNFEWTYP RMESGRLVEP VTDFLFEMPH IRSILHIPSA ELGDSGTYIC NVSESVSDHR 300 DEKAINVTVV ENGYVRLLGE LDPVQFAELH RSRTLQVVFE AYPPPTVMWF KDNRTLGDSS 360 AGEIVLSTRN VSETRYVSEL TLVRVKVAEA GYYTMRAFHE DAEAQLSFQL QVNVPVRVLE 420 LSESHPANGE QTVRCRGRGM PQPHLTWSTC SDLKRCPREL PPTPLGNSSE EESQLETNVT 480 YWAEEQEFEV VSTLRLRHVD QPLSVRCTLH NLLGYDVQEV TVVPHSLPFK VVVISAILAL 540 VVLTIISLII LIMLWQKKPR YEIRWKVIES VSSDGHEYIY VDPMQLPYDS TWELPRDQLV 600 LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 660 LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRCSDKRRPP SAELYSNALP 720 VGLPLPSHVS LPGESDGGYM DMSKDESVDY VPMLDMKGDV KYADIESSNY MAPYDNYVPS 780 APERTCRVTL INESPVLSYT DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK 840 ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 900 TPYPELPMNE QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFEIRPPF SQLVLLLERL 960 LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR LPGFNGLRSP LDSSSVLYTA VQPNEGDNDY 1020 IIPLPDPKPE VADEGPLEGS PSLASSTLNE VNTSSTISCD SPLEPQEEPE PEPQPASQVE 1080 PEPKWPPDSS CPGPRAEAED SFL 1103 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRB | 527165 | F1N759 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRB | A0A452FZS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PDGFRB | 5159 | P09619 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfrb | 18596 | P05622 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PDGFRB | A0A2I3T367 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480LAB1 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Pdgfrb | 24629 | Q05030 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031410 | cytoplasmic vesicle |
| GO:0005887 | integral component of plasma membrane |
| GO:0043202 | lysosomal lumen |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0019838 | growth factor binding |
| GO:0005019 | platelet-derived growth factor beta-receptor activity |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0005017 | platelet-derived growth factor-activated receptor activity |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0006935 | chemotaxis |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0007275 | multicellular organism development |
| GO:0033674 | positive regulation of kinase activity |
| GO:0014911 | positive regulation of smooth muscle cell migration |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0458 | Lysosome |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR027288 | PGFRB |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |