| Tag | Content |
|---|---|
| Uniprot ID | Q05030; Q8R406; Q925F7; |
| Entrez ID | 24629 |
| Genbank protein ID | CAA78489.1; AAK43716.1; AAM09098.1; |
| Genbank nucleotide ID | NM_031525.1; XM_006254789.3; |
| Ensembl protein ID | ENSRNOP00000069485; ENSRNOP00000060534; ENSRNOP00000070561; |
| Ensembl nucleotide ID | ENSRNOG00000018461 |
| Gene name | Platelet-derived growth factor receptor beta |
| Gene symbol | Pdgfrb |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity). |
| Sequence | MGLPEVMPAS VLRGQLLLFV LLLLGPQISQ GLVITPPGPE FVLNISSTFV LTCSSSAPVM 60 WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV YNNSLGPELS ERKRIYIFVP 120 DPTMGFLPMD SEDLFIFVTD VTETTIPCRV TDPQLEVTLH EKKVDIPLHV PYDHQRGFIG 180 TFEDKTYICK TTIGDREVDS DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND 240 VVNFQWTYPR MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG 300 DEKAINVTVI ENGYVRLLET LEDVQIAELH RSRTLQVVFE AYPTPSVLWF KDNRTLGDSS 360 AGELVLSTRN VSETRYVSEL TLVRVKVSEA GYYTMRAFHA DDQVQLSFKL QVNVPVRVLE 420 LSESHPANGE QILRCRGRGM PQPNVTWSTC RDLKRCPRKL SPTPLGNSSK EESQLETNVT 480 FWEEDQEYEV VSTLRLRHVD QPLSVRCMLQ NSMGRDSQEV TVVPHSLPFK VVVISAILAL 540 VVLTVISLII LIMLWQRKPR YEIRWKVIES VSSDGHEYIY VDPVQLPYDS TWELPRDQLV 600 LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 660 LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRHSNKHCPP STELYSNALP 720 VGLSLPSHLN LTGESDGGYM DMSKDESVDY VPMLDMKGHI KYADIESSSY MAPYDNYVPS 780 APERTYRATL INDSPVLSYT DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK 840 ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 900 TPYPELPMND QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFETRPPF SQLVLLLERL 960 LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR LPGLHSLRSP LDTSSVLYTA VQPNETDNDY 1020 IIPLPDPKPD AADEGLLEGS PSLASSTLNE VNTSSTISCD SPLELQEEPQ AEPEAQLEQP 1080 QDSGCPGPLA EAEDSFL 1097 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRB | 527165 | F1N759 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRB | A0A452FZS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PDGFRB | 5159 | P09619 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfrb | 18596 | P05622 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PDGFRB | A0A2I3T367 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480LAB1 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Pdgfrb | 24629 | Q05030 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016324 | apical plasma membrane |
| GO:0009986 | cell surface |
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005794 | Golgi apparatus |
| GO:0005887 | integral component of plasma membrane |
| GO:0031226 | intrinsic component of plasma membrane |
| GO:0043202 | lysosomal lumen |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0001726 | ruffle |
| GO:0005524 | ATP binding |
| GO:0019899 | enzyme binding |
| GO:0019838 | growth factor binding |
| GO:0016301 | kinase activity |
| GO:0043548 | phosphatidylinositol 3-kinase binding |
| GO:0005019 | platelet-derived growth factor beta-receptor activity |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0005161 | platelet-derived growth factor receptor binding |
| GO:0005017 | platelet-derived growth factor-activated receptor activity |
| GO:0004672 | protein kinase activity |
| GO:0019901 | protein kinase binding |
| GO:0004713 | protein tyrosine kinase activity |
| GO:0005102 | signaling receptor binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0038085 | vascular endothelial growth factor binding |
| GO:0030325 | adrenal gland development |
| GO:0007568 | aging |
| GO:0035909 | aorta morphogenesis |
| GO:0001568 | blood vessel development |
| GO:0055003 | cardiac myofibril assembly |
| GO:0060326 | cell chemotaxis |
| GO:0016477 | cell migration |
| GO:0060981 | cell migration involved in coronary angiogenesis |
| GO:0035441 | cell migration involved in vasculogenesis |
| GO:0070301 | cellular response to hydrogen peroxide |
| GO:0048568 | embryonic organ development |
| GO:0006024 | glycosaminoglycan biosynthetic process |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0001701 | in utero embryonic development |
| GO:0048839 | inner ear development |
| GO:0035556 | intracellular signal transduction |
| GO:0001822 | kidney development |
| GO:0060437 | lung growth |
| GO:0008584 | male gonad development |
| GO:0072278 | metanephric comma-shaped body morphogenesis |
| GO:0072277 | metanephric glomerular capillary formation |
| GO:0072262 | metanephric glomerular mesangial cell proliferation involved in metanephros development |
| GO:0072223 | metanephric glomerular mesangium development |
| GO:0072275 | metanephric glomerulus morphogenesis |
| GO:0035789 | metanephric mesenchymal cell migration |
| GO:0072075 | metanephric mesenchyme development |
| GO:0072284 | metanephric S-shaped body morphogenesis |
| GO:0007275 | multicellular organism development |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0006807 | nitrogen compound metabolic process |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:0046488 | phosphatidylinositol metabolic process |
| GO:0048015 | phosphatidylinositol-mediated signaling |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0090280 | positive regulation of calcium ion import |
| GO:0030335 | positive regulation of cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| GO:0050921 | positive regulation of chemotaxis |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:2000573 | positive regulation of DNA biosynthetic process |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:2000491 | positive regulation of hepatic stellate cell activation |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043406 | positive regulation of MAP kinase activity |
| GO:0035793 | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| GO:0045840 | positive regulation of mitotic nuclear division |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| GO:0010863 | positive regulation of phospholipase C activity |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| GO:0035025 | positive regulation of Rho protein signal transduction |
| GO:0014911 | positive regulation of smooth muscle cell migration |
| GO:0048661 | positive regulation of smooth muscle cell proliferation |
| GO:0046777 | protein autophosphorylation |
| GO:0032956 | regulation of actin cytoskeleton organization |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| GO:0106096 | response to ceramide |
| GO:0032355 | response to estradiol |
| GO:0043627 | response to estrogen |
| GO:0034405 | response to fluid shear stress |
| GO:0042542 | response to hydrogen peroxide |
| GO:0055093 | response to hyperoxia |
| GO:0033993 | response to lipid |
| GO:0014070 | response to organic cyclic compound |
| GO:0032526 | response to retinoic acid |
| GO:0009636 | response to toxic substance |
| GO:0061298 | retina vasculature development in camera-type eye |
| GO:0097178 | ruffle assembly |
| GO:0007165 | signal transduction |
| GO:0048705 | skeletal system morphogenesis |
| GO:0071670 | smooth muscle cell chemotaxis |
| GO:0048745 | smooth muscle tissue development |
| GO:0001894 | tissue homeostasis |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0042060 | wound healing |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0458 | Lysosome |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR027288 | PGFRB |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |