| Tag | Content |
|---|---|
| Uniprot ID | A0A480LAB1 |
| Entrez ID | |
| Genbank protein ID | HDA39894.1; HDA55206.1; HDA70726.1; HDA68999.1; HDA39144.1; HCZ95501.1; HDA70728.1; HDB49166.1; HDA33607.1; HDA53931.1; HDA70727.1; HDA28220.1; HDA70729.1; HDA32722.1; HDA71748.1; HDA38595.1; HDA44241.1; HDA32509.1; HDA26060.1; HDA55204.1; HDA55205.1; HDB20020.1; HDA53933.1; HDA39142.1; HDA53932.1; HDA39893.1; HCZ94769.1; HCZ93616.1; HDA39143.1; HDA53934.1; HDA53936.1; HDA39141.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Platelet-derived growth factor receptor beta |
| Gene symbol | |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. |
| Sequence | MQLPRAVPAS VLIGQVLLLP PLLLLGPQAS WGLVITPPGP ELVLNLSSTF VLTCSGPAPV 60 VWERMSQKPP QEMTGTQDGT FSSVLTLANV TGLDTGEYFC TYKGSPGLEA SERKRLYIFV 120 PDPAVGFLPV DPEELFIFLT EITETTIPCR VTDPRLVVTL HEKKVDVPLP ISYDHQRGFS 180 GTFEDKTYVC KTTIGDREVD SDAYYVYSLQ VSSINVSVGA VQTVVRQGEN ITVMCIVTGN 240 EVVNFEWTYP RLETGRLVEP VTDFLFEMPH IRSILHIPSA ELGDSGTYIC NVSESVSDHR 300 DEKAINVTVV ESGYVRLIGE LDAVQFAELH RSRTLQVVFE AYPPPTVIWF KDNRTLGDSG 360 AGEIALSTRN VSETRYVSEL TLVRVKVAEA GRYTMRAFHE DAEAQISFQL QVNVPVRVLE 420 LSESHPASGE QTVRCRGRGM PQPHLTWSTC SDLKRCPREL PPTPLGNSSE EESQLETNVT 480 YWPQEQEFEV VSTLRLRRVD QPLSVRCTLH NLLGHDAQEV TVVPHSLPFQ VVVVSAVLAL 540 VVLTVISLII LVMLWQKKPR YEIRWKVIES VSSDGHEYIY VDPMQLPYDS TWELPRDQLV 600 LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 660 LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD FLHRNKHTFL QRCSDKRRPP SAELYSNALP 720 VGLPLPSHVA LPGESDGGYM DMSKDESVDY VPMLDMRGDV KYADIQPSGY MAPYDNCVPS 780 APERTCRPTL INESPVLSYT DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK 840 ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 900 TPYPELPMNE QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFEIRPPF SQLVLLLERL 960 LGEGYKKKYQ QVDEEFLRSD HPAVLRSQAR LPGFPGLRSP LDSSPVLYTA VQPNEGDNDY 1020 IIPLPDPKPE VADEGPLEGA PSLASSTLNE VNTASTISCD SPLEPQEEPE PEPQLEPRGE 1080 LEPEPERPLE AGCPGPRAEA EDSFL 1105 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRB | 527165 | F1N759 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRB | A0A452FZS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PDGFRB | 5159 | P09619 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfrb | 18596 | P05622 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PDGFRB | A0A2I3T367 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480LAB1 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Pdgfrb | 24629 | Q05030 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031410 | cytoplasmic vesicle |
| GO:0016021 | integral component of membrane |
| GO:0043202 | lysosomal lumen |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0005019 | platelet-derived growth factor beta-receptor activity |
| GO:0006935 | chemotaxis |
| GO:0007275 | multicellular organism development |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0458 | Lysosome |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR027288 | PGFRB |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |